Reactome | DARS [cytosol]

DARS [cytosol]

Stable Identifier

R-HSA-379605

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Aspartyl-tRNA synthetase

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- MITF-M-regulated melanocyte development (Homo sapiens)
  - Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
    - MAPK-dependent phosphorylation of KARS (Homo sapiens)
      - KARS-depleted MSC [cytosol] (Homo sapiens)
        
        DARS homodimer [cytosol] (Homo sapiens)
        
        DARS [cytosol] (Homo sapiens)
      - aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
        
        DARS homodimer [cytosol] (Homo sapiens)
        
        DARS [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14868 DARS1

Gene Names

DARS1, DARS, PIG40

Chain

chain:1-501

Reference Genes

BioGPS Gene:1615 DARS1

COSMIC (genes):DARS DARS1

CTD Gene:1615 DARS1

dbSNP Gene:1615 DARS1

ENSEMBL:ENSG00000115866 DARS

HGNC:2678 DARS1

KEGG:hsa:1615 DARS1

Monarch:1615 DARS1

NCBI Gene:1615 DARS1

OMIM:603084 DARS1

UCSC:P14868 DARS1

Reference Transcript

Other Identifiers

11746468_a_at

11746469_x_at

11756661_a_at

1615

16903111

201623_PM_s_at

201623_s_at

201624_PM_at

201624_at

2577955

2577957

2577959

2577960

2577963

2577964

2577965

2577966

2577968

2577970

2577971

2577972

2577974

2577975

2577976

2577977

2577985

2577986

2577987

2577991

2577992

2577994

2577997

2577998

2577999

2578000

2578002

2578003

2578004

2578005

2578006

32615_at

45961_i_at

45962_r_at

8055445

A_23_P108415

A_33_P3531857

GE57523

GO:0000166

GO:0003676

GO:0003723

GO:0003824

GO:0004046

GO:0004812

GO:0004815

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006399

GO:0006412

GO:0006418

GO:0006422

GO:0006520

GO:0016020

GO:0016787

GO:0016874

GO:0017101

GO:0043226

GO:0045202

GO:0065003

GO:0070062

GO:0140098

HMNXSV003004553

ILMN_1813836

J05032_at

PH_hs_0022093

TC02002377.hg

g12653688_3p_a_at

Participates

as a component of

DARS homodimer [cytosol] (Homo sapiens)

Inferred To

DARS [cytosol] (Dictyostelium discoideum)

DARS [cytosol] (Gallus gallus)

DARS [cytosol] (Mus musculus)

DARS [cytosol] (Rattus norvegicus)

DARS1 [cytosol] (Bos taurus)

DARS1 [cytosol] (Canis familiaris)

DARS1 [cytosol] (Sus scrofa)

AspRS [cytosol] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSG00000115866, ENST00000264161, ENSP00000264161

OpenTargets

ENSG00000115866

GeneCards

DARS1

HPA

ENSG00000115866-DARS1

PRO

P14868

Pharos - Targets

P14868

GlyGen

P14868

Orphanet

DARS1

HMDB Protein

HMDBP00608

PDB

4J15, 5Y6L, 6IY6

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	16
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.564	2
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.527	3
UniProt:Q08050 FOXM1	3	p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) FOXM1 [nucleoplasm] (R-HSA-4088019)	0.499	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	2