phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate

Stable Identifier
R-HSA-379848
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FARS (cytosolic phenylalanyl tRNA synthetase) catalyzes the reaction of phenylalanine, tRNA(Phe), and ATP to form Phe-tRNA(Phe), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a heterotetramer of two alpha and two beta subunits (Moor et al. 2002).

Literature References
PubMed ID Title Journal Year
11858721 Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes

Moor, N, Linshiz, G, Safro, M

Protein Expr Purif 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phenylalanine-tRNA ligase activity of FARS A2B2 tetramer [cytosol]
Physical Entity
Activity
Authored
Reviewed
Created