isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate

Stable Identifier
R-HSA-380176
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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IARS2 (mitochondrial isoleucyl tRNA synthetase) catalyzes the reaction of isoleucine, mitochondrial tRNA(Ile), and ATP to form Ile-tRNA(Ile), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Degoul et al. 1995).

Literature References
PubMed ID Title Journal Year
9466989 Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene

Degoul, F, Brule, H, Cepanec, C, Helm, M, Marsac, C, Leroux, J, Giege, R, Florentz, C

Hum Mol Genet 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
isoleucine-tRNA ligase activity of IARS2 [mitochondrial matrix]
Physical Entity
Activity
Authored
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Created