valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate

Stable Identifier
R-HSA-380199
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate
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VARS2 (mitochondrial valyl tRNA synthetase) catalyzes the reaction of valine, mitochondrial tRNA(val), and ATP to form Val-tRNA(Val), AMP, and pyrophosphate. The VARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).
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Catalyst Activity

valine-tRNA ligase activity of VARS2 [mitochondrial matrix]

Physical Entity
VARS2 [mitochondrial matrix] (Homo sapiens)
Activity
valine-tRNA ligase activity (GO:0004832)
Inferred From
tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)
aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-08)
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