leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate

Stable Identifier
R-HSA-380200
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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LARS2 (mitochondrial leucyl tRNA synthetase) catalyzes the reaction of leucine, mitochondrial tRNA(Leu), and ATP to form Leu-tRNA(Leu), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer (Bullard et al. 2000).

Literature References
PubMed ID Title Journal Year
10684970 Expression and characterization of the human mitochondrial leucyl-tRNA synthetase

Bullard, JM, Cai, YC, Spremulli, LL

Biochim Biophys Acta 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
leucine-tRNA ligase activity of LARS2(1-?) [mitochondrial matrix]
Physical Entity
Activity
Authored
Reviewed
Created