phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate

Stable Identifier
R-HSA-380203
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

FARS2 (mitochondrial phenylalanyl tRNA synthetase) catalyzes the reaction of phenylalanine, mitochondrial tRNA(Phe), and ATP to form Phe-tRNA(Phe), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a monomer (Bullard et al. 1999).

Literature References
PubMed ID Title Journal Year
10329163 Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase

Bullard, JM, Cai, YC, Demeler, B, Spremulli, LL

J Mol Biol 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phenylalanine-tRNA ligase activity of FARS2(1-?) [mitochondrial matrix]
Physical Entity
Activity
Authored
Reviewed
Created