Reactome | CNTRL [cytosol]

CNTRL [cytosol]

Stable Identifier

R-HSA-380256

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Centriolin

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CNTRL [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7Z7A1 CNTRL

Gene Names

CNTRL, CEP1, CEP110

Chain

chain:1-2325

Reference Genes

BioGPS Gene:11064 CNTRL

COSMIC (genes):CNTRL CNTRL

CTD Gene:11064 CNTRL

dbSNP Gene:11064 CNTRL

ENSEMBL:ENSG00000119397 CNTRL

ENSEMBL_homo_sapiens_GENE:ENSG00000119397.19 CNTRL

HGNC:1858 CNTRL

KEGG Gene (Homo sapiens):11064 CNTRL

Monarch:11064 CNTRL

NCBI Gene:11064 CNTRL

OMIM:605496 CNTRL

UCSC:Q7Z7A1 CNTRL

Reference Transcript

Other Identifiers

11064

11723378_a_at

11747135_x_at

17088589

205642_PM_at

205642_at

242916_PM_at

242916_at

3187578

3187581

3187582

3187583

3187584

3187585

3187587

3187588

3187589

3187591

3187592

3187597

3187600

3187601

3187602

3187604

3187605

3187606

3187611

3187614

3187615

3187616

3187618

3187619

3187620

3187622

3187623

3187625

3187626

3187627

3187629

3187630

3187631

3187634

3187635

3187636

3187637

3187639

3187641

3187643

3187644

3187645

3187647

3187648

3187649

3187651

3187654

3187656

3187659

3187661

3187663

3187664

3187665

3187666

3187667

3187669

3187671

3187673

3187675

3187677

3187678

3187679

38345_at

44276_at

8157534

A_14_P101943

A_14_P125697

A_23_P43580

GE54734

GO:0001822

GO:0003279

GO:0003281

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0007049

GO:0016020

GO:0034451

GO:0035904

GO:0043226

GO:0048471

GO:0048856

GO:0051301

GO:0060976

GO:0072687

GO:0090543

GO:0090619

GO:0097431

GO:0120103

HMNXSV003010464

HMNXSV003022067

Hs.191649.0.S1_3p_at

Hs.191649.0.S1_3p_s_at

ILMN_1758778

TC09000607.hg

g5901923_3p_at

Participates

as a component of

Inferred To

Ghost homologue of CNTRL [cytosol] (Bos taurus)

Ghost homologue of CNTRL [cytosol] (Mus musculus)

Ghost homologue of CNTRL [cytosol] (Rattus norvegicus)

Ghost homologue of CNTRL [cytosol] (Xenopus tropicalis)

CNTRL [cytosol] (Canis familiaris)

CNTRL [cytosol] (Gallus gallus)

CNTRL [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_005251736.1, NP_008949.4, NP_001317691.1

OpenTargets

ENSG00000119397

GeneCards

Q7Z7A1

HPA

ENSG00000119397-CNTRL

Ensembl

ENSP00000362956, ENSP00000362962, ENSG00000119397, ENST00000373850, ENST00000373855

PRO

Q7Z7A1

Pharos - Targets

Q7Z7A1

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