Loss of Nlp from mitotic centrosomes

Stable Identifier
R-HSA-380259
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Pathway
Species
Homo sapiens
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During interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated at the onset of mitosis and phosphorylates Nlp triggering its displacement from the centrosome (Casenghi et al.,2003). Removal of Nlp appears to contribute to the establishment of a mitotic scaffold with enhanced microtubule nucleation activity.

Literature References
PubMed ID Title Journal Year
12852856 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation

Casenghi, M, Meraldi, P, Weinhart, U, Duncan, PI, K├Ârner, R, Nigg, EA

Dev Cell 2003
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Orthologous Events
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Created