Reactome | HAUS2 [cytosol]

HAUS2 [cytosol]

Stable Identifier

R-HSA-380274

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep27, HAUS2_HUMAN

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NVX0 HAUS2

Gene Names

HAUS2, C15orf25, CEP27

Chain

chain:1-235

Reference Genes

BioGPS Gene:55142 HAUS2

COSMIC (genes):HAUS2 HAUS2

CTD Gene:55142 HAUS2

dbSNP Gene:55142 HAUS2

ENSEMBL:ENSG00000137814 HAUS2

ENSEMBL_homo_sapiens_GENE:ENSG00000137814.12 HAUS2

HGNC:25530 HAUS2

KEGG Gene (Homo sapiens):55142 HAUS2

Monarch:55142 HAUS2

NCBI Gene:55142 HAUS2

OMIM:613429 HAUS2

UCSC:Q9NVX0 HAUS2

Reference Transcript

Other Identifiers

11728819_x_at

11728820_a_at

11744197_s_at

16800108

220071_3p_x_at

220071_PM_x_at

220071_x_at

228744_PM_at

228744_at

229181_PM_s_at

229181_s_at

229208_PM_at

229208_at

2451079

2796323

3591045

3591046

3591049

3591050

3591052

3591053

3591056

3591057

3591058

3591059

3591060

3591061

3591062

3591063

3591064

3591066

3591068

3591070

3591072

3591074

3776461

3776462

41187_at

44197_at

55142

57662_at

63986_at

77024_at

7983123

A_32_P144220

A_33_P3832852

A_33_P3832857

GE55752

GE85007

GO:0003674

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005876

GO:0007010

GO:0007020

GO:0007049

GO:0007059

GO:0007098

GO:0010968

GO:0031023

GO:0043226

GO:0051225

GO:0051301

GO:0065003

GO:0070652

GO:1990498

HMNXSV003013085

HMNXSV003013725

HMNXSV003031712

Hs.14347.1.S1_3p_a_at

Hs.14347.1.S2_3p_at

Hs.283732.0.A1_3p_at

ILMN_1738482

TC15000321.hg

g829622_3p_at

g8922429_3p_x_at

Participates

as a component of

HAUS complex [cytosol] (Homo sapiens)

Inferred To

Haus2 [cytosol] (Mus musculus)

HAUS2 [cytosol] (Bos taurus)

HAUS2 [cytosol] (Canis familiaris)

HAUS2 [cytosol] (Gallus gallus)

HAUS2 [cytosol] (Sus scrofa)

haus2 [cytosol] (Xenopus tropicalis)

Ghost homologue of HAUS2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_060567.1, NP_001123919.1, XP_016877885.1, NP_001310560.1, XP_016877886.1, NP_001310561.1

OpenTargets

ENSG00000137814

GeneCards

Q9NVX0

HPA

ENSG00000137814-HAUS2

Ensembl

ENSP00000456578, ENST00000568876, ENST00000260372, ENSP00000260372, ENSG00000137814

PRO

Q9NVX0

Pharos - Targets

Q9NVX0

PDB

7SQK

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13426 XRCC4	2	monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892) XRCC4 [nucleoplasm] (R-HSA-75911)	0.556	3

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