Reactome | CSNK1D [cytosol]

CSNK1D [cytosol]

Stable Identifier

R-HSA-380315

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casein kinase I, delta

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1D [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48730 CSNK1D

Gene Names

CSNK1D, HCKID

Chain

chain:1-415

Reference Genes

COSMIC (genes):CSNK1D CSNK1D

dbSNP Gene:1453 CSNK1D

ENSEMBL:ENSG00000141551 CSNK1D

Participates

as a component of

as an output of

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

as a candidate of

CSNK1E,CSNK1D [cytosol] (Homo sapiens)

This entity regulates

Positively

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

Other forms of this molecule

CSNK1D [nucleoplasm]

CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]

Inferred To

Csnk1d [cytosol] (Mus musculus)

CSNK1D [cytosol] (Bos taurus)

CSNK1D [cytosol] (Canis familiaris)

CSNK1D [cytosol] (Gallus gallus)

CSNK1D [cytosol] (Rattus norvegicus)

CSNK1D [cytosol] (Sus scrofa)

CSNK1D [cytosol] (Xenopus tropicalis)

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15055 PER2	4	Ub-p-S-PER2 [cytosol] (R-HSA-517835) PER2 [cytosol] (R-HSA-400399) p-S-PER2 [nucleoplasm] (R-HSA-3325591) p-S-PER2 [cytosol] (R-HSA-400331)	0.756	6
UniProt:Q14C86 GAPVD1	1	GAPVD1 [cytosol] (R-HSA-8871123)	0.669	4
UniProt:P23508 CRCM			0.669	5
UniProt:Q5T7W0 ZN618			0.666	4
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.666	4
UniProt:Q6ZRV2 FA83H			0.643	5
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cilium] (R-HSA-5632507) CSNK1A1 [cytosol] (R-HSA-195263)	0.643	3
UniProt:Q96LR2 LURA1			0.61	4
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.61	6
UniProt:Q15154 PCM1	1	PCM1 [cytosol] (R-HSA-380308)	0.569	3
UniProt:Q9C026 TRIM9	1	TRIM9 [cytosol] (R-HSA-976054)	0.556	3
UniProt:Q6PGQ1 DRIC1			0.556	3
UniProt:O75382 TRIM3	1	TRIM3 [cytosol] (R-HSA-5624344)	0.556	3
UniProt:O60447 EVI5			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q9H2S9 IKZF4			0.556	3
UniProt:Q96BR9 ZBT8A			0.556	3
UniProt:Q9P286 PAK5	2	PAK5 [cytosol] (R-HSA-428459) PAK7 [plasma membrane] (R-HSA-211555)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q49A88-3 CCDC14			0.556	3
UniProt:Q99996 AKAP9	3	AKAP9(1-1118)-BRAF(381-766) fusion [cytosol] (R-HSA-6802267) AKAP9(1-1118)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802514) AKAP9 [cytosol] (R-HSA-380260)	0.527	3
UniProt:Q5T0W9 FAM83B	1	FAM83B [cytosol] (R-HSA-9715184)	0.527	3
UniProt:Q7Z5H3 ARHGAP22	1	ARHGAP22 [cytosol] (R-HSA-200762)	0.527	2
UniProt:Q8TC76 F110B			0.527	2
UniProt:Q9Y343 SNX24			0.527	3
UniProt:Q8WVL7 ANR49			0.527	2
UniProt:Q6PEV8 F199X			0.527	2
UniProt:Q9H4H8 FAM83D	1	FAM83D [cytosol] (R-HSA-9852722)	0.527	2
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.527	2
UniProt:Q7Z7G8 VP13B			0.527	3
UniProt:Q9H9R9 DBND1			0.527	2
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.527	3
UniProt:Q9UIM3 FKBPL	1	FKBPL [cytosol] (R-HSA-8852374)	0.527	2
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.527	3
UniProt:Q16526 CRY1	4	Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) CRY1 [cytosol] (R-HSA-400247) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.527	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.527	2