Reactome | CSNK1D [cytosol]

CSNK1D [cytosol]

Stable Identifier

R-HSA-380315

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casein kinase I, delta

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Locations in the PathwayBrowser for interactor UniProt:Q5T7W0 ZN618

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External Reference Information

External Reference

UniProt:P48730 CSNK1D

Gene Names

CSNK1D, HCKID

Chain

chain:1-415

Reference Genes

BioGPS Gene:1453 CSNK1D

COSMIC (genes):CSNK1D CSNK1D

CTD Gene:1453 CSNK1D

dbSNP Gene:1453 CSNK1D

ENSEMBL:ENSG00000141551 CSNK1D

HGNC:2452 CSNK1D

KEGG:hsa:1453 CSNK1D

Monarch:1453 CSNK1D

NCBI Gene:1453 CSNK1D

OMIM:600864 CSNK1D

UCSC:P48730 CSNK1D

Reference Transcript

Participates

as a component of

as an output of

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

as a member of

CSNK1D,CSNK1E [cytosol] (Homo sapiens)

This entity regulates

Positively

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

Other forms of this molecule

CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]

CSNK1D [nucleoplasm]

Inferred To

Csnk1d [cytosol] (Mus musculus)

CSNK1D [cytosol] (Bos taurus)

CSNK1D [cytosol] (Canis familiaris)

CSNK1D [cytosol] (Gallus gallus)

CSNK1D [cytosol] (Rattus norvegicus)

CSNK1D [cytosol] (Sus scrofa)

CSNK1D [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_620693.1, NP_001884.2

Guide to Pharmacology - Targets

1997

OpenTargets

ENSG00000141551

ENSEMBL

ENSP00000376146, ENST00000392334, ENST00000314028, ENSP00000324464, ENSG00000141551

ZINC - FDA approved

KC1D_HUMAN

ZINC - Substances

KC1D_HUMAN

ZINC - Biogenic

KC1D_HUMAN

ZINC target

P48730

PRO

P48730

PDB

4KB8, 6F1W, 4HNF, 4KBC, 6PXN, 6PXO, 6GZM, 8VXD, 8D7P, 6PXP, 8VXF, 5MQV, 3UYT, 4KBA, 6F26, 3UYS, 7NZY, 3UZP, 4TWC, 6HMR, 8IZC, 6RCH, 6RCG, 4TW9, 7QRA, 7P7G, 5IH6, 4TN6, 5OKT, 7QR9, 4HGT, 9B3S, 6HMP, 5W4W, 8D7M, 8D7N, 6RU8, 5IH5, 5IH4, 7QRB, 7P7H, 6RU7, 7P7F, 4KBK, 8D7O, 6RU6

ZINC - Investigational

KC1D_HUMAN

ZINC - Metabolites

KC1D_HUMAN

GeneCards

CSNK1D

HPA

ENSG00000141551-CSNK1D

Pharos - Targets

P48730

Orphanet

CSNK1D

ZINC - Predictions - Purchasable

KC1D_HUMAN

HMDB Protein

HMDBP09458

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15055 PER2	5	PER2 [cytosol] (R-HSA-400399) p-7S-PER2 [nucleoplasm] (R-HSA-9920680) p-7S-PER2 [cytosol] (R-HSA-9920710) p-S396-PER2 [cytosol] (R-HSA-9920705) K48polyUb-K,p-7S-PER2 [cytosol] (R-HSA-9932526)	0.756	6
UniProt:P23508 CRCM			0.669	5
UniProt:Q14C86 GAPVD1	1	GAPVD1 [cytosol] (R-HSA-8871123)	0.669	4
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.666	4
UniProt:Q5T7W0 ZN618			0.666	4
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.643	3
UniProt:Q6ZRV2 FA83H			0.643	5
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.61	6
UniProt:Q96LR2 LURA1			0.61	4
UniProt:Q15154 PCM1	1	PCM1 [cytosol] (R-HSA-380308)	0.569	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q49A88-3 CCDC14			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q9P286 PAK5	2	PAK5 [cytosol] (R-HSA-428459) PAK7 [plasma membrane] (R-HSA-211555)	0.556	3
UniProt:Q96BR9 ZBT8A			0.556	3
UniProt:Q9H2S9 IKZF4			0.556	3
UniProt:O60447 EVI5			0.556	3
UniProt:O75382 TRIM3	1	TRIM3 [cytosol] (R-HSA-5624344)	0.556	3
UniProt:Q6PGQ1 DRIC1			0.556	3
UniProt:Q9C026 TRIM9	1	TRIM9 [cytosol] (R-HSA-976054)	0.556	3
UniProt:Q49AN0 CRY2	5	CRY2 [cytosol] (R-HSA-400255) p-S-CRY2 [nucleoplasm] (R-HSA-400328) p-S-CRY2 [cytosol] (R-HSA-400305) K48polyUb-K126,p-S-CRY2 [cytosol] (R-HSA-9932882) K48polyUb-K,p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.527	3
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.527	2
UniProt:Q9UIM3 FKBPL	1	FKBPL [cytosol] (R-HSA-8852374)	0.527	2
UniProt:O15534 PER1	4	PER1 [cytosol] (R-HSA-400373) p-S-PER1 [nucleoplasm] (R-HSA-3325590) p-S-PER1 [cytosol] (R-HSA-400310) K48polyUb-K,p-S-PER1 [cytosol] (R-HSA-517831)	0.527	3
UniProt:Q7Z7G8 VP13B			0.527	3
UniProt:Q9H9R9 DBND1			0.527	2
UniProt:Q9H4H8 FAM83D	1	FAM83D [cytosol] (R-HSA-9852722)	0.527	2
UniProt:Q6PEV8 F199X			0.527	2
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.527	2
UniProt:Q8WVL7 ANR49			0.527	2
UniProt:Q16526 CRY1	5	K48polyUb-K,p-S-CRY1 [nucleoplasm] (R-HSA-517931) K48polyUb-K107,p-S-CRY1 [cytosol] (R-HSA-9932884) p-S-CRY1 [cytosol] (R-HSA-400270) p-S-CRY1 [nucleoplasm] (R-HSA-400340) CRY1 [cytosol] (R-HSA-400247)	0.527	3
UniProt:Q9Y343 SNX24			0.527	3
UniProt:Q8TC76 F110B			0.527	2
UniProt:Q7Z5H3 ARHGAP22	1	ARHGAP22 [cytosol] (R-HSA-200762)	0.527	2
UniProt:Q5T0W9 FAM83B	1	FAM83B [cytosol] (R-HSA-9715184)	0.527	3
UniProt:Q99996 AKAP9	3	AKAP9(1-1118)-BRAF(381-766) fusion [cytosol] (R-HSA-6802267) AKAP9(1-1118)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802514) AKAP9 [cytosol] (R-HSA-380260)	0.527	3

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