Reactome: A Curated Pathway Database

Association of NuMA with microtubules

Stable Identifier
R-HSA-380316
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NuMA can interact with microtubules by direct binding to tubulin. Binding occurs through amino acids 1868-1967 of human NuMA (tail IIA) and appears to play a role in the organization of the spindle poles by stably crosslinking microtubule fibers (Haren and Merdes 2002). While the exact mechanism of microtubule bundling is not known, NuMA has been shown to form large fibrous networks (Saredi et al. 1996, Gueth-Hallonet et al.1998, Harborth et al.1999) apparently as a result of dimerization of the NuMA rod domains followed by association of multiple NuMA dimers through their tail domains.

Literature References
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Orthologous Events