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STAT5B [cytosol]
Stable Identifier
R-HSA-380737
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Signal transducer and activator of transcription 5B, STA5B_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)
Phosphorylation of STAT5 by cytosolic FGFR1 fusions (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
STAT5 Activation (Homo sapiens)
Activator phosphorylates STAT5 (Homo sapiens)
Activators of STAT5:STAT5 [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Activators bind STAT5 (Homo sapiens)
Activators of STAT5:STAT5 [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
STAT5 association with GHR (Homo sapiens)
Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5 tyrosine phosphorylation (Homo sapiens)
Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Prolactin receptor signaling (Homo sapiens)
PRLR binds STAT5 (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
PRLR-bound STAT5 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
STAT3,STAT5,(STAT3:STAT5) [cytosol] (Homo sapiens)
STAT3:STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT3,STAT5,(STAT3:STAT5) [cytosol] (Homo sapiens)
STAT3:STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
STAT3,STAT5,(STAT3:STAT5) [cytosol] (Homo sapiens)
STAT3:STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Recruited STAT5 is phosphorylated (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Interleukin-21 signaling (Homo sapiens)
IL21 receptor STAT binding (Homo sapiens)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Homo sapiens)
STAT1,STAT3,STAT4,STAT5 [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT1,STAT3,STAT4,STAT5 [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
IL21 receptor STAT phosphorylation (Homo sapiens)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Homo sapiens)
STAT1,STAT3,STAT4,STAT5 [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Interleukin-9 signaling (Homo sapiens)
IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Homo sapiens)
IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT1,STAT3,STAT5A,STAT5B [plasma membrane] (Homo sapiens)
STATs [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STATs [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Homo sapiens)
IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT1,STAT3,STAT5A,STAT5B [plasma membrane] (Homo sapiens)
STATs [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5 [plasma membrane] (Homo sapiens)
STAT1, STAT2, STAT3, STAT4, STAT5 [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5 [plasma membrane] (Homo sapiens)
STAT1, STAT2, STAT3, STAT4, STAT5 [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT1, STAT2, STAT3, STAT4, STAT5 [cytosol] (Homo sapiens)
STAT5 [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Activation of STAT5a/b by JAK2 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5 is recruited by JAK2 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates STAT5 (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Signaling by Leptin (Homo sapiens)
JAK2 Phosphorylates STAT5 in Response to Leptin (Homo sapiens)
LEP:p-LEPR:p-JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Phosphorylated LEPR Binds STAT5 (Homo sapiens)
LEP:p-LEPR:p-JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
STAT binds to the active receptor (Homo sapiens)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Homo sapiens)
STAT family members [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
STAT family members [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Phosphorylation of STATs (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
STATs [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
Recruitment of STATs (Homo sapiens)
STATs [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
STATs [cytosol] (Homo sapiens)
STAT5B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51692 STAT5B
Gene Names
STAT5B
Chain
chain:1-787
Reference Genes
BioGPS Gene:6777 STAT5B
COSMIC (genes):STAT5B STAT5B
CTD Gene:6777 STAT5B
dbSNP Gene:6777 STAT5B
ENSEMBL:ENSG00000173757 STAT5B
HGNC:11367 STAT5B
KEGG Gene (Homo sapiens):6777 STAT5B
Monarch:6777 STAT5B
NCBI Gene:6777 STAT5B
OMIM:604260 STAT5B
UCSC:P51692 STAT5B
Reference Transcript
RefSeq:NM_012448.3 STAT5B
Other Identifiers
0001660746
11720228_at
11720229_a_at
16845096
205026_at
212549_at
212550_at
33869_at
3721664
3721670
3721671
3721672
3721673
3721680
3721687
3757771
3757772
3757773
3757774
3757775
3757776
3757777
3757778
3757780
3757781
3757782
3757785
3757786
3757787
3757789
3757791
3757793
3757795
3757796
3757798
3757799
3757800
3757801
3757803
3757805
3757807
3757808
3757811
3757812
3757824
42128
4298
472_at
473_g_at
49883
51156
6777
8015590
A_23_P100788
A_33_P3380867
AAC50485
AAC50491
AAH65227
AJ412888
AJ412889
AJ412890
AJ412891
AJ412892
AJ412893
AJ412894
AJ412895
AJ412896
AJ412897
AJ412898
AJ412899
BC065227
C9J4I3
CAB004298
CAD19638
CCDS11423
ENSG00000173757
ENSP00000293328
ENST00000293328
ENST00000293328.7
EntrezGene:6777
EntrezGene:STAT5B
g6912687_3p_at
GE56366
GE61443
GO:0000978
GO:0000981
GO:0001228
GO:0002376
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006790
GO:0006950
GO:0006952
GO:0007165
GO:0007259
GO:0008134
GO:0008150
GO:0008283
GO:0009058
GO:0019221
GO:0019530
GO:0030154
GO:0032355
GO:0032870
GO:0034641
GO:0035259
GO:0035723
GO:0038110
GO:0038111
GO:0038113
GO:0040007
GO:0040014
GO:0042127
GO:0042592
GO:0043226
GO:0043434
GO:0044281
GO:0045648
GO:0045944
GO:0046983
GO:0048856
GO:0060397
GO:0071363
GO:0071364
HGNC:11367
HPA042128
HPA049883
HPA051156
Hs.24064.0.A1_3p_at
Hs.24064.0.A2_3p_at
ILMN_1684034
ILMN_1777783
IPR000980
IPR001217
IPR008967
IPR012345
IPR013799
IPR013800
IPR013801
IPR015988
IPR035858
IPR035886
IPR036535
IPR036860
LRG_192
LRG_192t1
MIM:245590
MIM:604260
NM_012448
NP_036580
PF00017
PF01017
PF02864
PF02865
PH_hs_0025369
SM00252
SM00964
STAT5B
STAT5B-201
TC17001529.hg
U47686
U47686_s_at
U48730
U48730_at
UPI000006F059
XM_017024977
XM_024450897
XM_024450898
XP_016880466
XP_024306665
XP_024306666
Participant Of
hasCandidate
STAT5 [cytosol]
hasMember
STAT family members [cytosol]
STAT5A,STAT5B [cytosol]
STATs [cytosol]
Other forms of this molecule
p-STAT5B [nucleoplasm]
p-STAT5B [cytosol]
p-Y699-STAT5B [nucleoplasm]
p-Y699-STAT5B [cytosol]
Inferred To
STAT5B [cytosol] (Caenorhabditis elegans)
STAT5B [cytosol] (Canis familiaris)
STAT5B [cytosol] (Danio rerio)
STAT5B [cytosol] (Dictyostelium discoideum)
STAT5B [cytosol] (Drosophila melanogaster)
STAT5B [cytosol] (Gallus gallus)
STAT5B [cytosol] (Mus musculus)
STAT5B [cytosol] (Rattus norvegicus)
STAT5B [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_036580.2
OpenTargets
ENSG00000173757
ZINC - Substances
STA5B_HUMAN
GeneCards
P51692
ZINC target
P51692
PRO
P51692
ZINC - Predictions - Purchasable
STA5B_HUMAN
Orphanet
15564
PDB
6MBZ
,
6MBW
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9UGK3 STAP2
2
STAP2 [cytosol]
(R-HSA-8848028)
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
0.524
10
UniProt:P38936 CDKN1A
5
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
0.488
2
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.488
2
UniProt:O75604 USP2
2
USP2 [nucleoplasm]
(R-HSA-5689946)
USP2 [cytosol]
(R-HSA-5212661)
0.488
2
UniProt:Q71SY5 MED25
1
MED25 [nucleoplasm]
(R-HSA-212414)
0.488
2
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