STAT binds to the active receptor

Stable Identifier
R-HSA-380782
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Among the seven members of the STAT family, STAT1, STAT3, STAT5 alpha and -beta, and STAT6 have been shown to bind to the activated PDGF beta-receptor (PDGFRB) and to be phosphorylated after PDGF stimulation; binding also occurs to the alpha-receptor (PDGFRA), albeit only weakly.

Literature References
PubMed ID Title Journal Year
8657151 Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins

Vignais, ML, Sadowski, HB, Watling, D, Rogers, NC, Gilman, M

Mol Cell Biol 1996
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
9484840 Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains

Valgeirsdóttir, S, Paukku, K, Silvennoinen, O, Heldin, CH, Claesson-Welsh, L

Oncogene 1998
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!