Reactome | PPM1A [cytosol]

PPM1A [cytosol]

Stable Identifier

R-HSA-380928

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35813 PPM1A

Gene Names

PPM1A, PPPM1A

Chain

initiator methionine:1, chain:2-382

Reference Genes

BioGPS Gene:5494 PPM1A

COSMIC (genes):PPM1A PPM1A

CTD Gene:5494 PPM1A

dbSNP Gene:5494 PPM1A

ENSEMBL:ENSG00000100614 PPM1A

HGNC:9275 PPM1A

KEGG Gene (Homo sapiens):5494 PPM1A

Monarch:5494 PPM1A

NCBI Gene:5494 PPM1A

OMIM:606108 PPM1A

UCSC:P35813 PPM1A

Reference Transcript

Other Identifiers

0000840164

0001230035

0005900551

04658+3.1.3.16

04660+3.1.3.16

11720672_a_at

11720673_a_at

11720674_a_at

11726945_at

11726946_at

16784909

1A6Q

203966_s_at

210407_at

227728_at

229027_at

235344_at

29209

3538556

3538558

3538559

3538560

3538561

3538569

3538570

3538571

3538572

3538573

3538574

3538575

3538576

3538577

3538578

3538579

3538580

3538581

3538582

3538583

3538584

3538585

3538586

3538587

36435_at

36501_at

3FXJ

3FXK

3FXL

3FXM

3FXO

4RA2

4RAF

4RAG

50725_at

53315_at

5494

60213_at

6B67

7974781

857_at

A0A024R6A5

A_14_P135788

A_23_P151679

A_23_P409553

A_24_P407323

A_24_P688133

AAB21784

AAC28354

AAH26691

AAH63243

AB451247

AF070670

AK097843

AL132778

AL157756

BAG70061

BC026691

BC063243

CCDS45120

CCDS9744

CCDS9745

CH471061

E9PJN3

E9PKB5

E9PL75

E9PNE1

E9PP44

EAW80774

EAW80775

EAW80777

ENSG00000100614

ENSP00000314850

ENSP00000327255

ENSP00000378514

ENST00000325642

ENST00000325642.7

ENST00000325658

ENST00000325658.3

ENST00000395076

ENST00000395076.8

EntrezGene:5494

EntrezGene:PPM1A

g10337594_3p_at

g3372871_3p_at

GE58830

GE88748

GO:0000122

GO:0000287

GO:0003674

GO:0003824

GO:0004721

GO:0004722

GO:0004724

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006470

GO:0006499

GO:0006810

GO:0006913

GO:0007049

GO:0007050

GO:0007165

GO:0007267

GO:0008150

GO:0009058

GO:0010991

GO:0016020

GO:0016311

GO:0016787

GO:0016791

GO:0022607

GO:0030145

GO:0030512

GO:0030514

GO:0033192

GO:0034641

GO:0035970

GO:0043123

GO:0043124

GO:0043167

GO:0043169

GO:0043226

GO:0045893

GO:0046827

GO:0046872

GO:0065003

GO:0070412

GO:0071560

GO:0090263

GO:1901223

HGNC:9275

HPA029209

Hs.108829.0.A1_3p_at

Hs.56022.0.A1_3p_at

Hs.86022.0.A1_3p_at

ILMN_1690077

ILMN_1727127

ILMN_1903159

ILMN_2296045

ILMN_2410516

IPR000222

IPR001932

IPR012911

IPR015655

IPR036457

IPR036580

MIM:606108

NM_021003

NM_177951

NM_177952

NP_066283

NP_808820

NP_808821

PF00481

PF07830

PH_hs_0022431

PH_hs_0037349

PPM1A

PPM1A-201

PPM1A-202

PPM1A-203

S87759

S87759_at

SM00332

TC14000362.hg

TC14001719.hg

TC14001720.hg

UPI000002B03A

UPI00001103E2

UPI0000E01530

XM_005267779

XM_005267781

XM_011536872

XM_011536876

XM_011536877

XM_011536878

XM_011536879

XM_011536880

XM_011536881

XM_011536882

XM_011536883

XM_017021381

XM_017021382

XM_017021383

XM_017021384

XM_017021385

XM_017021386

XM_017021387

XM_024449637

XP_005267836

XP_005267838

XP_011535174

XP_011535178

XP_011535179

XP_011535180

XP_011535181

XP_011535182

XP_011535183

XP_011535184

XP_011535185

XP_016876870

XP_016876871

XP_016876872

XP_016876873

XP_016876874

XP_016876875

XP_016876876

XP_024305405

Other forms of this molecule

PPM1A [nucleoplasm]

Inferred To

Homologues of PPM1A [cytosol] (Bos taurus)

Homologues of PPM1A [cytosol] (Caenorhabditis elegans)

Homologues of PPM1A [cytosol] (Drosophila melanogaster)

PPM1A [cytosol] (Bos taurus)

PPM1A [cytosol] (Caenorhabditis elegans)

PPM1A [cytosol] (Canis familiaris)

PPM1A [cytosol] (Danio rerio)

PPM1A [cytosol] (Drosophila melanogaster)

PPM1A [cytosol] (Gallus gallus)

PPM1A [cytosol] (Mus musculus)

PPM1A [cytosol] (Rattus norvegicus)

PPM1A [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_016876876.1, XP_011535186.1, XP_005267836.1, XP_011535181.1, XP_016876873.1, XP_011535180.1, XP_011535182.1, NP_808821.2, XP_005267838.1, XP_016876874.1, XP_011535184.1, XP_011535183.1, XP_016876875.1, NP_808820.1, XP_011535185.1, NP_066283.1

OpenTargets

ENSG00000100614

GeneCards

P35813

ZINC - Substances

PPM1A_HUMAN

ZINC target

P35813

PRO

P35813

ZINC - Predictions - Purchasable

PPM1A_HUMAN

HMDB Protein

HMDBP08792

PDB

4RAF, 3FXM, 4RAG, 1A6Q, 3FXK, 3FXJ, 6B67, 3FXL, 4RA2, 3FXO

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	7	MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.611	19
UniProt:Q9H6Z4 RANB3			0.602	4
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.553	2
UniProt:Q15796 SMAD2	15	p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) SMAD2 [nucleoplasm] (R-HSA-3006352) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 S464L [cytosol] (R-HSA-3304383)	0.544	2
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.508	2
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.508	2
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512)	0.499	2
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.499	3
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	4