Reactome | PPM1A [cytosol]

PPM1A [cytosol]

Stable Identifier

R-HSA-380928

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35813 PPM1A

Gene Names

PPM1A, PPPM1A

Chain

initiator methionine:1, chain:2-382

Reference Genes

BioGPS Gene:5494 PPM1A

COSMIC (genes):PPM1A PPM1A

CTD Gene:5494 PPM1A

dbSNP Gene:5494 PPM1A

ENSEMBL:ENSG00000100614 PPM1A

HGNC:9275 PPM1A

KEGG Gene (Homo sapiens):5494 PPM1A

Monarch:5494 PPM1A

NCBI Gene:5494 PPM1A

OMIM:606108 PPM1A

UCSC:P35813 PPM1A

Reference Transcript

Other Identifiers

0000840164

0001230035

0005900551

11720672_a_at

11720673_a_at

11720674_a_at

11726945_at

11726946_at

16784909

203966_s_at

210407_at

227728_at

229027_at

235344_at

3538556

3538558

3538559

3538560

3538561

3538569

3538570

3538571

3538572

3538573

3538574

3538575

3538576

3538577

3538578

3538579

3538580

3538581

3538582

3538583

3538584

3538585

3538586

3538587

36435_at

36501_at

50725_at

53315_at

5494

60213_at

7974781

857_at

A_14_P135788

A_23_P151679

A_23_P409553

A_24_P407323

A_24_P688133

GE58830

GE88748

GO:0000122

GO:0000287

GO:0003674

GO:0003824

GO:0004721

GO:0004722

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006470

GO:0006499

GO:0006810

GO:0006913

GO:0007049

GO:0007050

GO:0007165

GO:0007267

GO:0008150

GO:0009058

GO:0010991

GO:0015031

GO:0016020

GO:0016311

GO:0016787

GO:0016791

GO:0022607

GO:0030145

GO:0030512

GO:0030514

GO:0033192

GO:0034641

GO:0035970

GO:0043123

GO:0043124

GO:0043167

GO:0043169

GO:0043226

GO:0045893

GO:0046827

GO:0046872

GO:0065003

GO:0070412

GO:0071560

GO:0090263

GO:1901223

Hs.108829.0.A1_3p_at

Hs.56022.0.A1_3p_at

Hs.86022.0.A1_3p_at

ILMN_1690077

ILMN_1727127

ILMN_1903159

ILMN_2296045

ILMN_2410516

PH_hs_0022431

PH_hs_0037349

S87759_at

TC14000362.hg

TC14001719.hg

TC14001720.hg

g10337594_3p_at

g3372871_3p_at

Other forms of this molecule

PPM1A [nucleoplasm]

Inferred To

Homologues of PPM1A [cytosol] (Caenorhabditis elegans)

Homologues of PPM1A [cytosol] (Drosophila melanogaster)

PPM1A [cytosol] (Bos taurus)

PPM1A [cytosol] (Canis familiaris)

PPM1A [cytosol] (Gallus gallus)

Ppm1a [cytosol] (Mus musculus)

Ppm1a [cytosol] (Rattus norvegicus)

alph [cytosol] (Drosophila melanogaster)

ppm1a [cytosol] (Xenopus tropicalis)

tap-1 [cytosol] (Caenorhabditis elegans)

ppm-1.A [cytosol] (Caenorhabditis elegans)

ppm1aa [cytosol] (Danio rerio)

Dmel\CG6036 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_066283.1, XP_011535183.1, XP_016876873.1, NP_808821.2, XP_011535180.1, XP_011535184.1, NP_808820.1, XP_016876876.1, XP_011535185.1, XP_011535181.1, XP_016876874.1, XP_016876875.1, XP_005267838.1, XP_011535186.1, XP_011535182.1, XP_005267836.1

OpenTargets

ENSG00000100614

HPA

ENSG00000100614-PPM1A

ZINC - Substances

PPM1A_HUMAN

GeneCards

P35813

ZINC target

P35813

Ensembl

ENSP00000327255, ENST00000395076, ENSP00000314850, ENST00000325658, ENST00000325642, ENSP00000378514, ENSG00000100614

PRO

P35813

ZINC - Predictions - Purchasable

PPM1A_HUMAN

PDB

3FXO, 4RAG, 6B67, 4RA2, 3FXM, 3FXL, 1A6Q, 3FXK, 4RAF, 3FXJ

HMDB Protein

HMDBP08792

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.611	19
UniProt:Q9H6Z4 RANB3			0.602	4
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.553	2
UniProt:Q15796 SMAD2	27	p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 Q429* [cytosol] (R-HSA-9668727) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) SMAD2 [nucleoplasm] (R-HSA-3006352) SMAD2 [cytosol] (R-HSA-3006353) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185)	0.544	2
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.508	2
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.508	2
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864)	0.499	2
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.499	3
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	4

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