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PPM1A [cytosol]
Stable Identifier
R-HSA-380928
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
AMPK is dephosphorylated (Homo sapiens)
PPM1A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35813 PPM1A
Gene Names
PPM1A, PPPM1A
Chain
initiator methionine:1, chain:2-382
Reference Genes
BioGPS Gene:5494 PPM1A
COSMIC (genes):PPM1A PPM1A
CTD Gene:5494 PPM1A
dbSNP Gene:5494 PPM1A
ENSEMBL:ENSG00000100614 PPM1A
HGNC:9275 PPM1A
KEGG Gene (Homo sapiens):5494 PPM1A
Monarch:5494 PPM1A
NCBI Gene:5494 PPM1A
OMIM:606108 PPM1A
UCSC:P35813 PPM1A
Reference Transcript
RefSeq:XM_011536883.1 PPM1A
RefSeq:XM_017021387.1 PPM1A
RefSeq:XM_017021386.1 PPM1A
RefSeq:XM_005267779.1 PPM1A
RefSeq:XM_011536879.2 PPM1A
RefSeq:XM_011536884.1 PPM1A
RefSeq:NM_177952.2 PPM1A
RefSeq:XM_017021384.1 PPM1A
RefSeq:NM_177951.2 PPM1A
RefSeq:XM_011536878.1 PPM1A
RefSeq:NM_021003.4 PPM1A
RefSeq:XM_011536882.2 PPM1A
RefSeq:XM_011536881.2 PPM1A
RefSeq:XM_017021385.1 PPM1A
RefSeq:XM_011536880.2 PPM1A
RefSeq:XM_005267781.1 PPM1A
Other Identifiers
0000840164
0001230035
0005900551
11720672_a_at
11720673_a_at
11720674_a_at
11726945_at
11726946_at
16784909
203966_s_at
210407_at
227728_at
229027_at
235344_at
3538556
3538558
3538559
3538560
3538561
3538569
3538570
3538571
3538572
3538573
3538574
3538575
3538576
3538577
3538578
3538579
3538580
3538581
3538582
3538583
3538584
3538585
3538586
3538587
36435_at
36501_at
50725_at
53315_at
5494
60213_at
7974781
857_at
A_14_P135788
A_23_P151679
A_23_P409553
A_24_P407323
A_24_P688133
GE58830
GE88748
GO:0000122
GO:0000287
GO:0003674
GO:0003824
GO:0004721
GO:0004722
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006470
GO:0006499
GO:0006810
GO:0006913
GO:0007049
GO:0007050
GO:0007165
GO:0007267
GO:0008150
GO:0009058
GO:0010991
GO:0015031
GO:0016020
GO:0016311
GO:0016787
GO:0016791
GO:0022607
GO:0030145
GO:0030512
GO:0030514
GO:0033192
GO:0034641
GO:0035970
GO:0043123
GO:0043124
GO:0043167
GO:0043169
GO:0043226
GO:0045893
GO:0046827
GO:0046872
GO:0065003
GO:0070412
GO:0071560
GO:0090263
GO:1901223
Hs.108829.0.A1_3p_at
Hs.56022.0.A1_3p_at
Hs.86022.0.A1_3p_at
ILMN_1690077
ILMN_1727127
ILMN_1903159
ILMN_2296045
ILMN_2410516
PH_hs_0022431
PH_hs_0037349
S87759_at
TC14000362.hg
TC14001719.hg
TC14001720.hg
g10337594_3p_at
g3372871_3p_at
Other forms of this molecule
PPM1A [nucleoplasm]
Inferred To
Homologues of PPM1A [cytosol] (Caenorhabditis elegans)
Homologues of PPM1A [cytosol] (Drosophila melanogaster)
PPM1A [cytosol] (Bos taurus)
PPM1A [cytosol] (Canis familiaris)
PPM1A [cytosol] (Gallus gallus)
Ppm1a [cytosol] (Mus musculus)
Ppm1a [cytosol] (Rattus norvegicus)
alph [cytosol] (Drosophila melanogaster)
ppm1a [cytosol] (Xenopus tropicalis)
tap-1 [cytosol] (Caenorhabditis elegans)
ppm-1.A [cytosol] (Caenorhabditis elegans)
ppm1aa [cytosol] (Danio rerio)
Dmel\CG6036 [cytosol] (Drosophila melanogaster)
Cross References
RefSeq
NP_066283.1
,
XP_011535183.1
,
XP_016876873.1
,
NP_808821.2
,
XP_011535180.1
,
XP_011535184.1
,
NP_808820.1
,
XP_016876876.1
,
XP_011535185.1
,
XP_011535181.1
,
XP_016876874.1
,
XP_016876875.1
,
XP_005267838.1
,
XP_011535186.1
,
XP_011535182.1
,
XP_005267836.1
OpenTargets
ENSG00000100614
HPA
ENSG00000100614-PPM1A
ZINC - Substances
PPM1A_HUMAN
GeneCards
P35813
ZINC target
P35813
Ensembl
ENSP00000327255
,
ENST00000395076
,
ENSP00000314850
,
ENST00000325658
,
ENST00000325642
,
ENSP00000378514
,
ENSG00000100614
PRO
P35813
ZINC - Predictions - Purchasable
PPM1A_HUMAN
PDB
3FXO
,
4RAG
,
6B67
,
4RA2
,
3FXM
,
3FXL
,
1A6Q
,
3FXK
,
4RAF
,
3FXJ
HMDB Protein
HMDBP08792
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28482 MAPK1
18
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.611
19
UniProt:Q9H6Z4 RANB3
0.602
4
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.553
2
UniProt:Q15796 SMAD2
27
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
SMAD2 S467P [cytosol]
(R-HSA-3304375)
SMAD2 Q429* [cytosol]
(R-HSA-9668727)
p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009189)
SMAD2 [nucleoplasm]
(R-HSA-3006352)
SMAD2 [cytosol]
(R-HSA-3006353)
p-S465,S467-SMAD2 [cytosol]
(R-HSA-3009186)
p-S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009185)
0.544
2
UniProt:P08069 IGF1R
3
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.508
2
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.508
2
UniProt:O15169 AXIN1
11
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
AXIN1 [cytosol]
(R-HSA-195249)
p-T519,S524,S531-AXIN1 [cytosol]
(R-HSA-206040)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
0.499
2
UniProt:P32121 ARRB2
2
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [cytosol]
(R-HSA-416464)
0.499
3
UniProt:P49407 ARRB1
5
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [cytosol]
(R-HSA-264470)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
4
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