Reactome | PRKAA1 [cytosol]

PRKAA1 [cytosol]

Stable Identifier

R-HSA-380935

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMPK alpha1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, AAPK1_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        Activation of AMPK downstream of NMDARs (Homo sapiens)
        
        CAMKK2 phosphorylates AMPK (Homo sapiens)
        
        AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK alpha [cytosol] (Homo sapiens)
        
        PRKAA1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13131 PRKAA1

Gene Names

PRKAA1, AMPK1

Chain

chain:1-559

Reference Genes

BioGPS Gene:5562 PRKAA1

COSMIC (genes):PRKAA1 PRKAA1

CTD Gene:5562 PRKAA1

dbSNP Gene:5562 PRKAA1

ENSEMBL:ENSG00000132356 PRKAA1

HGNC:9376 PRKAA1

KEGG Gene (Homo sapiens):5562 PRKAA1

Monarch:5562 PRKAA1

NCBI Gene:5562 PRKAA1

OMIM:602739 PRKAA1

UCSC:Q13131 PRKAA1

Reference Transcript

Other Identifiers

0005130280

0105550711

11729314_a_at

11739209_a_at

11751517_a_at

16995685

209799_at

225984_at

225985_at

2854734

2854736

2854738

2854739

2854740

2854741

2854742

2854743

2854746

2854747

2854749

2854753

2854755

2854758

2854760

2854765

2854776

2854777

2854778

2854779

41015_at

48068_at

5562

8111796

A_23_P110725

A_33_P3257187

A_33_P3312212

GE53597

GE878012

GE895807

GO:0000166

GO:0000187

GO:0001666

GO:0003674

GO:0003682

GO:0004672

GO:0004674

GO:0004679

GO:0004691

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0005975

GO:0006006

GO:0006091

GO:0006325

GO:0006464

GO:0006468

GO:0006605

GO:0006629

GO:0006631

GO:0006633

GO:0006694

GO:0006695

GO:0006810

GO:0006914

GO:0006950

GO:0007005

GO:0007010

GO:0007049

GO:0007050

GO:0007165

GO:0007267

GO:0008022

GO:0008092

GO:0008150

GO:0008202

GO:0008203

GO:0008219

GO:0008283

GO:0008284

GO:0008610

GO:0009056

GO:0009058

GO:0009411

GO:0009631

GO:0010332

GO:0010468

GO:0010508

GO:0010628

GO:0010629

GO:0014823

GO:0015031

GO:0015721

GO:0016055

GO:0016126

GO:0016192

GO:0016236

GO:0016241

GO:0016301

GO:0016310

GO:0016324

GO:0016607

GO:0016740

GO:0019395

GO:0022607

GO:0030424

GO:0030425

GO:0031000

GO:0031588

GO:0031669

GO:0032007

GO:0032991

GO:0033135

GO:0034599

GO:0034641

GO:0035174

GO:0035404

GO:0035556

GO:0035690

GO:0038183

GO:0042149

GO:0042493

GO:0042542

GO:0042592

GO:0042593

GO:0042752

GO:0043025

GO:0043066

GO:0043167

GO:0043226

GO:0044281

GO:0044877

GO:0045542

GO:0045821

GO:0046318

GO:0046627

GO:0046872

GO:0047322

GO:0048156

GO:0048511

GO:0048643

GO:0048856

GO:0050321

GO:0050405

GO:0050995

GO:0051276

GO:0055089

GO:0060627

GO:0061744

GO:0061762

GO:0062028

GO:0070050

GO:0070301

GO:0070507

GO:0071277

GO:0071333

GO:0071361

GO:0071380

GO:0071417

GO:0071456

GO:0097009

GO:0106310

GO:0106311

GO:0120188

GO:1901563

GO:1901796

GO:1903109

GO:1903829

GO:1903955

GO:1904428

GO:1904486

GO:2000758

HMNXSV003036598

Hs.107057.0.A1_3p_at

Hs.107057.0.A2_3p_at

ILMN_1783889

ILMN_2357577

PH_hs_0022119

TC05001298.hg

Y12856_at

g5410311_3p_at

Participates

as a member of

AMPK alpha [cytosol] (Homo sapiens)

Other forms of this molecule

p-T183-PRKAA1 [cytosol]

p-T183-PRKAA1 [nucleoplasm]

Inferred To

prkaa1 [cytosol] (Danio rerio)

prkaa1 [cytosol] (Xenopus tropicalis)

Prkaa1 [cytosol] (Mus musculus)

Prkaa1 [cytosol] (Rattus norvegicus)

SNF1 [cytosol] (Saccharomyces cerevisiae)

PRKAA1 [cytosol] (Bos taurus)

PRKAA1 [cytosol] (Canis familiaris)

PRKAA1 [cytosol] (Gallus gallus)

PTK1 [cytosol] (Saccharomyces cerevisiae)

aak-2 [cytosol] (Caenorhabditis elegans)

AMPKalpha [cytosol] (Drosophila melanogaster)

PTK2 [cytosol] (Saccharomyces cerevisiae)

Homologues of PRKAA1 [cytosol] (Caenorhabditis elegans)

Homologues of PRKAA1 [cytosol] (Dictyostelium discoideum)

Homologues of PRKAA1 [cytosol] (Saccharomyces cerevisiae)

Homologues of PRKAA1 [cytosol] (Schizosaccharomyces pombe)

aak-1 [cytosol] (Caenorhabditis elegans)

ppk9 [cytosol] (Schizosaccharomyces pombe)

ssp2 [cytosol] (Schizosaccharomyces pombe)

snfA [cytosol] (Dictyostelium discoideum)

mrkB [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_996790.3, NP_006242.5

Guide to Pharmacology - Targets

1541

OpenTargets

ENSG00000132356

ZINC target

Q13131

PRO

Q13131

GlyGen

Q13131

PDB

4RER, 6C9J, 6C9G, 6C9H, 6C9F, 4RED, 4REW, 5EZV

IntEnz

2.7.11.26, 2.7.11.31, 2.7.11.27

GeneCards

Q13131

HPA

ENSG00000132356-PRKAA1

Ensembl

ENSP00000380317, ENSG00000132356, ENST00000354209, ENST00000397128, ENSP00000346148

Pharos - Targets

Q13131

HMDB Protein

HMDBP01899

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75385 ULK1	7	p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) ULK1 [cytosol] (R-HSA-1632847) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) ULK1 [recycling endosome] (R-HSA-8854761)	0.669	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:P46937 YAP1	7	p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-5S-YAP1 [cytosol] (R-HSA-2028554)	0.564	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [nucleoplasm] (R-HSA-5082401)	0.527	2
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) PRKAA2 [nucleoplasm] (R-HSA-163682) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171)	0.527	3
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.527	2