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PRKAA1 [cytosol]
Stable Identifier
R-HSA-380935
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
AMPK alpha1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, AAPK1_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of AMPK downstream of NMDARs (Homo sapiens)
CAMKK2 phosphorylates AMPK (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK alpha [cytosol] (Homo sapiens)
PRKAA1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
AMPK is dephosphorylated (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK alpha [cytosol] (Homo sapiens)
PRKAA1 [cytosol] (Homo sapiens)
Activation of cytosolic AMPK by phosphorylation (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK alpha [cytosol] (Homo sapiens)
PRKAA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13131 PRKAA1
Gene Names
PRKAA1, AMPK1
Chain
chain:1-559
Reference Genes
BioGPS Gene:5562 PRKAA1
COSMIC (genes):PRKAA1 PRKAA1
CTD Gene:5562 PRKAA1
dbSNP Gene:5562 PRKAA1
ENSEMBL:ENSG00000132356 PRKAA1
HGNC:9376 PRKAA1
KEGG Gene (Homo sapiens):5562 PRKAA1
Monarch:5562 PRKAA1
NCBI Gene:5562 PRKAA1
OMIM:602739 PRKAA1
UCSC:Q13131 PRKAA1
Reference Transcript
RefSeq:NM_006251.5 PRKAA1
RefSeq:NM_206907.3 PRKAA1
Other Identifiers
0005130280
0105550711
11729314_a_at
11739209_a_at
11751517_a_at
16995685
209799_at
225984_at
225985_at
2854734
2854736
2854738
2854739
2854740
2854741
2854742
2854743
2854746
2854747
2854749
2854753
2854755
2854758
2854760
2854765
2854776
2854777
2854778
2854779
41015_at
48068_at
5562
8111796
A_23_P110725
A_33_P3257187
A_33_P3312212
GE53597
GE878012
GE895807
GO:0000166
GO:0000187
GO:0001666
GO:0003674
GO:0003682
GO:0004672
GO:0004674
GO:0004679
GO:0004691
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006006
GO:0006091
GO:0006325
GO:0006464
GO:0006468
GO:0006605
GO:0006629
GO:0006631
GO:0006633
GO:0006694
GO:0006695
GO:0006810
GO:0006914
GO:0006950
GO:0007005
GO:0007010
GO:0007049
GO:0007050
GO:0007165
GO:0007267
GO:0008022
GO:0008092
GO:0008150
GO:0008202
GO:0008203
GO:0008219
GO:0008283
GO:0008284
GO:0008610
GO:0009056
GO:0009058
GO:0009411
GO:0009631
GO:0010332
GO:0010468
GO:0010508
GO:0010628
GO:0010629
GO:0014823
GO:0015031
GO:0015721
GO:0016055
GO:0016126
GO:0016192
GO:0016236
GO:0016241
GO:0016301
GO:0016310
GO:0016324
GO:0016607
GO:0016740
GO:0019395
GO:0022607
GO:0030424
GO:0030425
GO:0031000
GO:0031588
GO:0031669
GO:0032007
GO:0032991
GO:0033135
GO:0034599
GO:0034641
GO:0035174
GO:0035404
GO:0035556
GO:0035690
GO:0038183
GO:0042149
GO:0042493
GO:0042542
GO:0042592
GO:0042593
GO:0042752
GO:0043025
GO:0043066
GO:0043167
GO:0043226
GO:0044281
GO:0044877
GO:0045542
GO:0045821
GO:0046318
GO:0046627
GO:0046872
GO:0047322
GO:0048156
GO:0048511
GO:0048643
GO:0048856
GO:0050321
GO:0050405
GO:0050995
GO:0051276
GO:0055089
GO:0060627
GO:0061744
GO:0061762
GO:0062028
GO:0070050
GO:0070301
GO:0070507
GO:0071277
GO:0071333
GO:0071361
GO:0071380
GO:0071417
GO:0071456
GO:0097009
GO:0120188
GO:1901563
GO:1901796
GO:1903109
GO:1903829
GO:1903955
GO:1904428
GO:1904486
GO:2000758
Hs.107057.0.A1_3p_at
Hs.107057.0.A2_3p_at
ILMN_1783889
ILMN_2357577
PH_hs_0022119
TC05001298.hg
Y12856_at
g5410311_3p_at
Participant Of
hasMember
AMPK alpha [cytosol]
Other forms of this molecule
p-T183-PRKAA1 [cytosol]
p-T183-PRKAA1 [nucleoplasm]
Inferred To
prkaa1 [cytosol] (Danio rerio)
prkaa1 [cytosol] (Xenopus tropicalis)
Prkaa1 [cytosol] (Mus musculus)
Prkaa1 [cytosol] (Rattus norvegicus)
SNF1 [cytosol] (Saccharomyces cerevisiae)
ssp2 [cytosol] (Schizosaccharomyces pombe)
PRKAA1 [cytosol] (Bos taurus)
PRKAA1 [cytosol] (Canis familiaris)
PRKAA1 [cytosol] (Gallus gallus)
aak-2 [cytosol] (Caenorhabditis elegans)
AMPKalpha [cytosol] (Drosophila melanogaster)
snfA [cytosol] (Dictyostelium discoideum)
Cross References
RefSeq
NP_006242.5
,
NP_996790.3
OpenTargets
ENSG00000132356
IntEnz
2.7.11.27
,
2.7.11.26
,
2.7.11.31
GeneCards
Q13131
HPA
ENSG00000132356-PRKAA1
ZINC target
Q13131
Ensembl
ENST00000397128
,
ENSG00000132356
,
ENSP00000346148
,
ENST00000354209
,
ENSP00000380317
PRO
Q13131
HMDB Protein
HMDBP01899
PDB
4REW
,
6C9G
,
4RED
,
4RER
,
5EZV
,
6C9F
,
6C9H
,
6C9J
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75385 ULK1
7
ULK1 [cytosol]
(R-HSA-1632847)
ULK1 [recycling endosome]
(R-HSA-8854761)
ULK1 [mitochondrial outer membrane]
(R-HSA-8948145)
p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-HSA-8948047)
p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-HSA-5675858)
p-S317,467,556,638,T575-ULK1 [cytosol]
(R-HSA-5673747)
p-S758-ULK1 [cytosol]
(R-HSA-5672131)
0.688
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:P46937 YAP1
7
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
YAP1 [nucleoplasm]
(R-HSA-1253322)
YAP1 [cytosol]
(R-HSA-1253345)
0.564
3
UniProt:P54646 PRKAA2
4
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.564
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:O14503 BHLHE40
1
BHLHE40 [nucleoplasm]
(R-HSA-879741)
0.556
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.527
2
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.527
2
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