Reactome | LKB1 forms a trimeric complex with STRAD and MO25

LKB1 forms a trimeric complex with STRAD and MO25

Stable Identifier

R-HSA-380942

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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LKB1 forms a trimeric complex with STRAD and MO25

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Upon complex formation with STRAD and MO25, LKB1 (also known as serine/threonine kinase 11, STK11) is mostly cytosolic. LKB1 attains 20x activity towards the substrates belonging to the subfamily of AMPK-like kinases (5'AMP-activated protein kinases).

Literature References

PubMed ID	Title	Journal	Year
12805220	Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD Clevers, HC, Medema, R, Smit, L, Alessi, DR, Baas, AF, Morrice, NA, Sapkota, GP, Boudeau, J	EMBO J	2003
14517248	MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm Prescott, AR, Clevers, HC, Schutkowski, M, Kieloch, A, Alessi, DR, Deak, M, Baas, AF, Morrice, NA, Boudeau, J	EMBO J	2003