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PRKAG1 [cytosol]
Stable Identifier
R-HSA-380946
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
AMPK gamma1, 5'-AMP-activated protein kinase subunit gamma-1, AAKG1_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Selective autophagy (Homo sapiens)
Lipophagy (Homo sapiens)
PRKAA2 phosphorylates PLINs (Homo sapiens)
AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Thr-180 of ULK1 is phosphorylated (Homo sapiens)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
ULK complex translocates to the ER (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
ULK1 phosphorylates Beclin-1 (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK:AMP binds the ULK complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
SESN1,2,3 bind AMPK (Homo sapiens)
SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of AMPK downstream of NMDARs (Homo sapiens)
AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
AMPK phosphorylates MAPT (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
CAMKK2 phosphorylates AMPK (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
AMPK is dephosphorylated (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Activation of cytosolic AMPK by phosphorylation (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Phosphorylated AMPK binds AMP (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54619 PRKAG1
Gene Names
PRKAG1
Chain
chain:1-331
Reference Genes
BioGPS Gene:5571 PRKAG1
COSMIC (genes):PRKAG1 PRKAG1
CTD Gene:5571 PRKAG1
dbSNP Gene:5571 PRKAG1
ENSEMBL:ENSG00000181929 PRKAG1
ENSEMBL_homo_sapiens_GENE:ENSG00000181929.13 PRKAG1
HGNC:9385 PRKAG1
KEGG Gene (Homo sapiens):5571 PRKAG1
Monarch:5571 PRKAG1
NCBI Gene:5571 PRKAG1
OMIM:602742 PRKAG1
UCSC:P54619 PRKAG1
Reference Transcript
RefSeq:XM_011538562.2 PRKAG1
RefSeq:NM_001206709.1 PRKAG1
RefSeq:XM_006719499.2 PRKAG1
RefSeq:NM_002733.4 PRKAG1
RefSeq:NM_001206710.1 PRKAG1
Other Identifiers
11730242_a_at
11741462_a_at
16764131
201805_PM_at
201805_at
34346_at
3453557
3453558
3453559
3453561
3453562
3453563
3453564
3453565
3453566
3453567
3453568
3453570
3453573
3453583
3453588
3453589
3453590
3453591
5571
7962935
A_23_P36513
A_33_P3340254
GE59156
GO:0000166
GO:0003824
GO:0004672
GO:0004691
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005975
GO:0006091
GO:0006110
GO:0006468
GO:0006629
GO:0006631
GO:0006633
GO:0006913
GO:0007165
GO:0007283
GO:0008603
GO:0010628
GO:0016020
GO:0016208
GO:0016740
GO:0019887
GO:0019901
GO:0022414
GO:0023052
GO:0031588
GO:0031669
GO:0036211
GO:0043226
GO:0043531
GO:0045860
GO:0051170
GO:0055086
GO:0098772
GO:0140096
GO:1901135
HMNXSV003016868
HMNXSV003050202
ILMN_1751984
ILMN_2412101
PH_hs_0000393
TC12003276.hg
U42412_at
g4506060_3p_at
Participates
as a member of
AMPK gamma [cytosol] (Homo sapiens)
Other forms of this molecule
PRKAG1 [nucleoplasm]
Inferred To
wu:fa94d09 [cytosol]
(Danio rerio)
Homologues of PRKAG1 [cytosol]
(Sus scrofa)
aakg-1 [cytosol]
(Caenorhabditis elegans)
PRKAG1 [cytosol]
(Bos taurus)
PRKAG1 [cytosol]
(Canis familiaris)
PRKAG1 [cytosol]
(Gallus gallus)
PRKAG1 [cytosol]
(Mus musculus)
PRKAG1 [cytosol]
(Rattus norvegicus)
PRKAG1 [cytosol]
(Saccharomyces cerevisiae)
PRKAG1 [cytosol]
(Schizosaccharomyces pombe)
PRKAG1 [cytosol]
(Sus scrofa)
SNF4Agamma [cytosol]
(Drosophila melanogaster)
prkag [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_002724.1
,
NP_001193638.1
,
XP_006719562.1
,
NP_001193639.1
,
XP_011536864.1
Guide to Pharmacology - Targets
1545
OpenTargets
ENSG00000181929
GeneCards
P54619
HPA
ENSG00000181929-PRKAG1
ZINC target
P54619
Ensembl
ENST00000316299
,
ENST00000552212
,
ENSG00000181929
,
ENSP00000323867
,
ENSP00000447433
,
ENST00000548065
,
ENSP00000448972
PRO
P54619
Pharos - Targets
P54619
Orphanet
28979
PDB
6C9G
,
4ZHX
,
4CFE
,
4CFF
,
2UV4
,
6C9F
,
7M74
,
2UV5
,
4RER
,
2UV6
,
6B1U
,
5ISO
,
7JHH
,
6C9J
,
4REW
,
7JHG
,
2UV7
,
6C9H
,
5EZV
,
6B2E
,
7MYJ
,
7JIJ
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.905
13
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.718
6
UniProt:O75385 ULK1
7
ULK1 [recycling endosome]
(R-HSA-8854761)
p-S758-ULK1 [cytosol]
(R-HSA-5672131)
p-S317,467,556,638,T575-ULK1 [cytosol]
(R-HSA-5673747)
p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-HSA-5675858)
p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-HSA-8948047)
ULK1 [cytosol]
(R-HSA-1632847)
ULK1 [mitochondrial outer membrane]
(R-HSA-8948145)
0.669
3
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.556
3
UniProt:P26367 PAX6
1
PAX6 [nucleoplasm]
(R-HSA-3009044)
0.556
3
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