Reactome | PRKAG1 [cytosol]

PRKAG1 [cytosol]

Stable Identifier

R-HSA-380946

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMPK gamma1, 5'-AMP-activated protein kinase subunit gamma-1, AAKG1_HUMAN

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Lipophagy (Homo sapiens)
      - PRKAA2 phosphorylates PLINs (Homo sapiens)
        
        AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - Thr-180 of ULK1 is phosphorylated (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK complex translocates to the ER (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates Beclin-1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - p-AMPK:AMP binds the ULK complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        SESN1,2,3 bind AMPK (Homo sapiens)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
        
        p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
    - AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
      - AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54619 PRKAG1

Gene Names

PRKAG1

Chain

chain:1-331

Reference Genes

BioGPS Gene:5571 PRKAG1

COSMIC (genes):PRKAG1 PRKAG1

CTD Gene:5571 PRKAG1

dbSNP Gene:5571 PRKAG1

ENSEMBL:ENSG00000181929 PRKAG1

HGNC:9385 PRKAG1

KEGG:hsa:5571 PRKAG1

Monarch:5571 PRKAG1

NCBI Gene:5571 PRKAG1

OMIM:602742 PRKAG1

UCSC:P54619 PRKAG1

Reference Transcript

Other Identifiers

11730242_a_at

11741462_a_at

11761138_x_at

16764131

201805_PM_at

201805_at

227527_PM_at

227527_at

34346_at

3453557

3453558

3453559

3453560

3453561

3453562

3453563

3453564

3453565

3453566

3453567

3453568

3453569

3453570

3453571

3453572

3453573

3453574

3453577

3453582

3453583

3453585

3453586

3453587

3453588

3453589

3453590

3453591

3453593

5571

7962935

A_23_P36513

A_33_P3340254

GE59156

GO:0000166

GO:0003824

GO:0004679

GO:0004691

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006110

GO:0006468

GO:0006629

GO:0006631

GO:0006633

GO:0006913

GO:0007165

GO:0007283

GO:0008603

GO:0016020

GO:0016208

GO:0016740

GO:0019887

GO:0019901

GO:0022414

GO:0031588

GO:0031669

GO:0032991

GO:0042149

GO:0043531

GO:0043609

GO:0044877

GO:0045722

GO:0051170

GO:0051726

GO:0140096

HMNXSV003016868

HMNXSV003050202

Hs.3640.0.S1_3p_a_at

Hs.3640.0.S1_3p_at

ILMN_1751984

ILMN_2412101

PH_hs_0000393

TC12003276.hg

U42412_at

g4506060_3p_at

Participates

as a member of

AMPK gamma [cytosol] (Homo sapiens)

Other forms of this molecule

PRKAG1 [nucleoplasm]

PRKAG1 [endoplasmic reticulum lumen]

Inferred To

prkag1 [cytosol] (Danio rerio)

prkag1 [cytosol] (Xenopus tropicalis)

aakg-4 [cytosol] (Caenorhabditis elegans)

aakg-3 [cytosol] (Caenorhabditis elegans)

Prkag1 [cytosol] (Mus musculus)

Prkag1 [cytosol] (Rattus norvegicus)

Homologues of PRKAG1 [cytosol] (Caenorhabditis elegans)

aakg-1 [cytosol] (Caenorhabditis elegans)

cbs2 [cytosol] (Schizosaccharomyces pombe)

PRKAG1 [cytosol] (Bos taurus)

PRKAG1 [cytosol] (Canis familiaris)

PRKAG1 [cytosol] (Gallus gallus)

PRKAG1 [cytosol] (Sus scrofa)

SNF4 [cytosol] (Saccharomyces cerevisiae)

SNF4Agamma [cytosol] (Drosophila melanogaster)

prkag [cytosol] (Dictyostelium discoideum)

aakg-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001193639.1, XP_011536864.1, XP_054228501.1, NP_001193638.1, NP_002724.1, XP_006719562.1

Guide to Pharmacology - Targets

1545

OpenTargets

ENSG00000181929

ENSEMBL

ENST00000548065, ENSP00000323867, ENSP00000447433, ENSG00000181929, ENST00000552212, ENST00000316299, ENSP00000448972

HPA

ENSG00000181929-PRKAG1

GeneCards

PRKAG1

ZINC target

P54619

PRO

P54619

Pharos - Targets

P54619

GlyGen

P54619

PDB

6C9J, 6B2E, 7JIJ, 6C9H, 4ZHX, 4CFF, 7M74, 7MYJ, 7JHH, 8BIK, 4CFE, 5EZV, 6C9G, 6C9F, 6B1U, 2UV6, 7JHG, 2UV7, 4RER, 5ISO, 2UV4, 2UV5, 4REW

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54646 PRKAA2	5	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) p-T172-PRKAA2 [endoplasmic reticulum lumen] (R-HSA-9931258) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.933	14
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.718	6
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.669	3
UniProt:P32239 CCKBR	1	CCKBR [plasma membrane] (R-HSA-388515)	0.643	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.527	2
UniProt:Q96RR4 CAMKK2	4	p-CAMKK2 [nucleoplasm] (R-HSA-9618968) CAMKK2 [nucleoplasm] (R-HSA-5336483) CAMKK2 [cytosol] (R-HSA-9619231) p-CAMKK2 [cytosol] (R-HSA-9619358)	0.527	2
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633)	0.527	4

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