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STK11 [cytosol]
Stable Identifier
R-HSA-380954
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
LKB1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
Activation of cytosolic AMPK by phosphorylation (Homo sapiens)
LKB1:STRAD:MO25 [cytosol] (Homo sapiens)
STK11 [cytosol] (Homo sapiens)
STK11 [cytosol] (Homo sapiens)
LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)
LKB1:STRAD:MO25 [cytosol] (Homo sapiens)
STK11 [cytosol] (Homo sapiens)
STK11 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15831 STK11
Gene Names
STK11, LKB1, PJS
Chain
chain:1-430, propeptide:431-433
Reference Genes
BioGPS Gene:6794 STK11
COSMIC (genes):STK11 STK11
CTD Gene:6794 STK11
dbSNP Gene:6794 STK11
ENSEMBL:ENSG00000118046 STK11
HGNC:11389 STK11
KEGG Gene (Homo sapiens):6794 STK11
Monarch:6794 STK11
NCBI Gene:6794 STK11
OMIM:602216 STK11
UCSC:Q15831 STK11
Reference Transcript
RefSeq:NM_000455.4 STK11
RefSeq:XM_005259618.3 STK11
Other Identifiers
0005050725
11735699_x_at
16856463
204292_x_at
231017_at
3815579
3815580
3815581
3815582
3815588
3815589
3815591
3815593
3815595
3815596
3815597
3815598
3815600
3815602
3815603
3815604
3815605
41657_at
6794
8024204
86312_at
A_23_P16483
A_24_P159866
A_33_P3389148
GE60471
GO:0000003
GO:0000166
GO:0000287
GO:0000902
GO:0001558
GO:0001894
GO:0001944
GO:0002039
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0006464
GO:0006468
GO:0006470
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0006974
GO:0007049
GO:0007050
GO:0007165
GO:0007267
GO:0007283
GO:0007409
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009056
GO:0010212
GO:0010508
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0030010
GO:0030111
GO:0030154
GO:0030234
GO:0030275
GO:0030295
GO:0030308
GO:0030511
GO:0030705
GO:0032147
GO:0040007
GO:0042592
GO:0042593
GO:0043167
GO:0043226
GO:0043276
GO:0045059
GO:0046777
GO:0046872
GO:0048814
GO:0048856
GO:0050772
GO:0050852
GO:0051645
GO:0051896
GO:0060070
GO:0060770
GO:0070062
GO:0071493
GO:0072332
GO:0090090
GO:0097484
GO:0120163
GO:1900182
GO:1901610
GO:1901796
GO:1904262
Hs.155647.0.S1_3p_at
ILMN_1751871
PH_hs_0015564
TC19001930.hg
TC19002617.hg
g4507270_3p_s_at
Participant Of
input
LKB1 forms a trimeric complex with STRAD and MO25
hasComponent
LKB1:STRAD:MO25 [cytosol]
Other forms of this molecule
STK11 [nucleoplasm]
Inferred To
Stk11 [cytosol] (Mus musculus)
Stk11 [cytosol] (Rattus norvegicus)
ppk34 [cytosol] (Schizosaccharomyces pombe)
STK11 [cytosol] (Bos taurus)
STK11 [cytosol] (Canis familiaris)
STK11 [cytosol] (Gallus gallus)
STK11 [cytosol] (Plasmodium falciparum)
STK11 [cytosol] (Sus scrofa)
TOS3 [cytosol] (Saccharomyces cerevisiae)
Homologues of STK11 [cytosol] (Plasmodium falciparum)
Cross References
RefSeq
NP_000446.1
,
XP_005259675.1
ZINC - World Drugs
STK11_HUMAN
OpenTargets
ENSG00000118046
ZINC - FDA approved
STK11_HUMAN
ZINC - Substances
STK11_HUMAN
ZINC - Biogenic
STK11_HUMAN
ZINC target
Q15831
PRO
Q15831
PDB
2WTK
,
5WXN
,
4ZDR
ZINC - Investigational
STK11_HUMAN
IntEnz
2.7.11.1
GeneCards
Q15831
HPA
ENSG00000118046-STK11
Ensembl
ENSG00000118046
,
ENST00000652231
,
ENSP00000324856
,
ENST00000326873
,
ENSP00000498804
ZINC - Predictions - Purchasable
STK11_HUMAN
Orphanet
15565
HMDB Protein
HMDBP01530
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7RTN6 STRADA
1
STRADA [cytosol]
(R-HSA-380960)
0.94
15
UniProt:Q9Y376 CAB39
4
CAB39 [extracellular region]
(R-HSA-6806462)
CAB39 [ficolin-1-rich granule lumen]
(R-HSA-6801287)
CAB39 [secretory granule lumen]
(R-HSA-6801288)
CAB39 [cytosol]
(R-HSA-380969)
0.926
15
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.813
5
UniProt:Q9C0K7 STRADB
1
STRADB [cytosol]
(R-HSA-380976)
0.702
6
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.688
3
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.683
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.641
4
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.61
6
UniProt:P54646 PRKAA2
4
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.589
3
UniProt:Q7RTN6-1 STRADA
0.564
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.564
2
UniProt:Q96L34 MARK4
1
MARK4 [cytosol]
(R-HSA-5626653)
0.544
2
UniProt:Q9NNW5 WDR6
0.543
3
UniProt:O95835 LATS1
2
p-S909,T1097-LATS1 [cytosol]
(R-HSA-2028551)
LATS1 [cytosol]
(R-HSA-2028562)
0.499
2
UniProt:P26927 MST1
3
MST1(484-711) [extracellular region]
(R-HSA-6800230)
MST1(19-483) [extracellular region]
(R-HSA-6800207)
pro-MST1 [extracellular region]
(R-HSA-6800227)
0.499
2
UniProt:Q8TEW0 PARD3
3
PARD3 [cytosol]
(R-HSA-419993)
PARD3 [plasma membrane]
(R-HSA-419980)
PARD3 [cell junction]
(R-HSA-2134481)
0.463
2
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