ATF4 activates genes in response to endoplasmic reticulum stress

Stable Identifier
R-HSA-380994
Type
Pathway
Species
Homo sapiens
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ATF4 activates genes in response to endoplasmic reticulum stress
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ATF4 is a transcription factor and activates expression of IL-8, MCP1, IGFBP-1, CHOP, HERP1 and ATF3.

Literature References
PubMed ID Title Journal Year
14742429 Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways

Ma, Y, Hendershot, LM

J Biol Chem 2004
18426796 Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK

Yamaguchi, Y, Larkin, D, Lara-Lemus, R, Ramos-Castañeda, J, Liu, M, Arvan, P

J Biol Chem 2008
16687408 Endoplasmic reticulum stress induction of insulin-like growth factor-binding protein-1 involves ATF4

Marchand, A, Tomkiewicz, C, Magne, L, Barouki, R, Garlatti, M

J Biol Chem 2006
14630918 Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation

Averous, J, Bruhat, A, Jousse, C, Carraro, V, Thiel, G, Fafournoux, P

J Biol Chem 2004
20022965 Regulation of Endoplasmic Reticulum Stress-induced Cell Death by ATF4 in Neuroectodermal Tumor Cells

Armstrong, JL, Flockhart, R, Veal, GJ, Lovat, PE, Redfern, CP

J Biol Chem 2010
16931790 The unfolded protein response is an important regulator of inflammatory genes in endothelial cells

Gargalovic, PS, Gharavi, NM, Clark, MJ, Pagnon, J, Yang, WP, He, A, Truong, A, Baruch-Oren, T, Berliner, JA, Kirchgessner, TG, Lusis, AJ

Arterioscler Thromb Vasc Biol 2006
16912112 Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids

Gargalovic, PS, Imura, M, Zhang, B, Gharavi, NM, Clark, MJ, Pagnon, J, Yang, WP, He, A, Truong, A, Patel, S, Nelson, SF, Horvath, S, Berliner, JA, Kirchgessner, TG, Lusis, AJ

Proc Natl Acad Sci U S A 2006
18840095 Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway

Gjymishka, A, Su, N, Kilberg, MS

Biochem J 2009
Participants
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Event Information
Go Biological Process
PERK-mediated unfolded protein response (0036499)
Authored
May, B  (2009-06-02)
Reviewed
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Gillespie, ME  (2008-12-02)
Urano, F  (2010-04-30)
Created
May, B  (2008-11-19)
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