Reactome | ATF4 activates genes

Stable Identifier

R-HSA-380994

Type

Pathway

Species

Homo sapiens

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Summation

ATF4 is a transcription factor and activates expression of IL-8, MCP1, IGFBP-1, CHOP, HERP1 and ATF3.

Literature References

PubMed ID	Title	Journal	Year
14742429	Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways	J Biol Chem	2004
18426796	Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK	J Biol Chem	2008
16687408	Endoplasmic reticulum stress induction of insulin-like growth factor-binding protein-1 involves ATF4	J Biol Chem	2006
14630918	Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation	J Biol Chem	2004
20022965	Regulation of Endoplasmic Reticulum Stress-induced Cell Death by ATF4 in Neuroectodermal Tumor Cells	J Biol Chem	2010
16931790	The unfolded protein response is an important regulator of inflammatory genes in endothelial cells	Arterioscler Thromb Vasc Biol	2006
16912112	Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids	Proc Natl Acad Sci U S A	2006
18840095	Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway	Biochem J	2009

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