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EIF2AK3 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-381046
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
PERK
Icon
Locations in the PathwayBrowser for interactor UniProt:P11021
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
EIF2AK3 phosphorylates NFE2L2 (Homo sapiens)
EIF2AK3 [endoplasmic reticulum membrane] (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
Dimerization of PERK (Homo sapiens)
EIF2AK3 [endoplasmic reticulum membrane] (Homo sapiens)
Dissociation of PERK:BiP Heterodimer (Homo sapiens)
EIF2AK3 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NZJ5 EIF2AK3
Gene Names
EIF2AK3, PEK, PERK
Chain
signal peptide:1-29, chain:30-1116
Reference Genes
BioGPS Gene:9451 EIF2AK3
COSMIC (genes):EIF2AK3 EIF2AK3
CTD Gene:9451 EIF2AK3
dbSNP Gene:9451 EIF2AK3
ENSEMBL:ENSG00000172071 EIF2AK3
ENSEMBL_homo_sapiens_GENE:ENSG00000172071.15 EIF2AK3
HGNC:3255 EIF2AK3
KEGG Gene (Homo sapiens):9451 EIF2AK3
Monarch:9451 EIF2AK3
NCBI Gene:9451 EIF2AK3
OMIM:604032 EIF2AK3
UCSC:Q9NZJ5 EIF2AK3
Reference Transcript
RefSeq:NM_004836.6 EIF2AK3
Other Identifiers
11722150_a_at
11722151_a_at
11722152_s_at
16900053
218696_PM_at
218696_at
2563662
2563663
2563664
2563666
2563668
2563676
2563678
2563679
2563682
2563683
2563684
2563685
2563686
2563687
2563688
2563689
2563690
2563695
2563703
2563704
2563705
2563706
2563707
2563708
2563709
48034_at
71344_at
8053668
9451
A_23_P135857
GE54955
GO:0000166
GO:0001501
GO:0001503
GO:0001525
GO:0002063
GO:0003824
GO:0004672
GO:0004674
GO:0004694
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0006351
GO:0006355
GO:0006417
GO:0006468
GO:0006919
GO:0006983
GO:0006986
GO:0007029
GO:0010468
GO:0010575
GO:0010628
GO:0010998
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0017148
GO:0018105
GO:0019722
GO:0019899
GO:0019903
GO:0023052
GO:0030154
GO:0030282
GO:0030968
GO:0031018
GO:0031642
GO:0032055
GO:0032057
GO:0034198
GO:0034976
GO:0036211
GO:0036492
GO:0036499
GO:0042149
GO:0042802
GO:0043226
GO:0045182
GO:0045943
GO:0046777
GO:0048009
GO:0048471
GO:0048856
GO:0050877
GO:0051171
GO:0051879
GO:0060734
GO:0070417
GO:0080090
GO:0106310
GO:0140096
GO:1900182
GO:1902235
GO:1990737
HMNXSV003004600
ILMN_1724984
PH_hs_0005684
TC02002074.hg
g4758891_3p_at
Participates
as an output of
Dissociation of PERK:BiP Heterodimer (Homo sapiens)
as a component of
PERK:BiP [endoplasmic reticulum membrane] (Homo sapiens)
PERK dimer [endoplasmic reticulum membrane] (Homo sapiens)
as an input of
Dimerization of PERK (Homo sapiens)
Other forms of this molecule
EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol]
EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol]
Inferred To
Homologues of EIF2AK3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
EIF2AK3 [endoplasmic reticulum membrane]
(Bos taurus)
EIF2AK3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
EIF2AK3 [endoplasmic reticulum membrane]
(Canis familiaris)
EIF2AK3 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
EIF2AK3 [endoplasmic reticulum membrane]
(Gallus gallus)
EIF2AK3 [endoplasmic reticulum membrane]
(Mus musculus)
EIF2AK3 [endoplasmic reticulum membrane]
(Rattus norvegicus)
EIF2AK3 [endoplasmic reticulum membrane]
(Sus scrofa)
EIF2AK3 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004827.4
Guide to Pharmacology - Targets
2017
OpenTargets
ENSG00000172071
ZINC - Substances
E2AK3_HUMAN
ZINC target
Q9NZJ5
PRO
Q9NZJ5
PDB
8EQD
,
4X7N
,
4X7J
,
4YZS
,
4G34
,
4X7L
,
4M7I
,
4X7H
,
4X7O
,
8EQE
,
8EQ9
,
7MF0
,
4G31
,
4X7K
,
5SV7
HPA
ENSG00000172071-EIF2AK3
GeneCards
Q9NZJ5
Ensembl
ENSP00000307235
,
ENSG00000172071
,
ENST00000303236
Pharos - Targets
Q9NZJ5
Orphanet
15919
ZINC - Predictions - Purchasable
E2AK3_HUMAN
HMDB Protein
HMDBP09502
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.589
4
UniProt:Q9NZJ5 EIF2AK3
3
EIF2AK3 [endoplasmic reticulum membrane]
(R-HSA-381046)
EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713456)
EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713454)
0.524
2
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