ATF6(1-380) [cytosol]

Stable Identifier
R-HSA-381075
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ATF6-alpha (aa 1-380), ATF6-alpha, N-terminal cleavage product of S2P
Locations in the PathwayBrowser
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General

ATF6-alpha is cleaved by S1P after amino acid 419 (RHLL). It is also cleaved by S2P at an unknown site. The product of cleavage is about 50 kd.

Literature References
PubMed ID Title Journal Year
11163209 ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

Ye, J, Rawson, RB, Komuro, R, Chen, X, Davé, UP, Prywes, R, Brown, MS, Goldstein, JL

Mol Cell 2000
External Reference Information
External Reference
UniProt:P18850 ATF6
Gene Names
ATF6
Chain
chain:1-670, chain:1-
Reference Genes
BioGPS Gene:22926 ATF6
COSMIC (genes):ATF6 ATF6
CTD Gene:22926 ATF6
dbSNP Gene:22926 ATF6
ENSEMBL:ENSG00000118217 ATF6
HGNC:791 ATF6
KEGG Gene (Homo sapiens):22926 ATF6
Monarch:22926 ATF6
NCBI Gene:22926 ATF6
OMIM:605537 ATF6
UCSC:P18850 ATF6
Reference Transcript
Other Identifiers
11740461_a_at
11745173_a_at
11745174_a_at
16672988
203952_3p_at
203952_at
217550_at
226941_at
22926
231927_at
2363921
2363922
2363923
2363925
2363928
2363929
2363931
2363933
2363934
2363938
2363940
2363951
2363955
2363956
2363957
2363960
2363961
2363966
2363978
2363979
2363980
2363981
2363982
2363983
2363984
2363985
2363986
2363987
338_at
52002_at
5935
7906819
83877_at
A_14_P112649
A_14_P139281
A_23_P62907
A_24_P453259
AAB64434
AAH14969
AAH71997
AB015856
AF005887
AF005887_at
AL359541
AL391825
AL450995
ATF6
ATF6-201
BAA34722
BC014969
BC071997
CCDS1235
ENSG00000118217
ENSP00000356919
ENST00000367942
ENST00000367942.3
EntrezGene:22926
EntrezGene:ATF6
g6671584_3p_at
g6671584_3p_s_at
g6671584_3p_x_at
GE62141
GE86196
GE86197
GO:0000139
GO:0000228
GO:0000790
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0001654
GO:0003674
GO:0003677
GO:0003700
GO:0003713
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006355
GO:0006357
GO:0006457
GO:0006950
GO:0006986
GO:0007165
GO:0007601
GO:0008150
GO:0008219
GO:0009058
GO:0016020
GO:0016021
GO:0019899
GO:0030176
GO:0030968
GO:0031625
GO:0034641
GO:0035497
GO:0036500
GO:0042802
GO:0043065
GO:0043226
GO:0043565
GO:0045944
GO:0046982
GO:0048856
GO:0050877
GO:1903893
GO:1990440
HGNC:791
HPA005935
Hs.158849.0.S1_3p_at
Hs.252497.0.A1_3p_at
Hs.40328.0.A1_3p_at
ILMN_1703471
IPR004827
IPR029801
MIM:605537
MIM:616517
NM_007348
NP_031374
PF00170
PH_hs_0025264
SM00338
TC01001414.hg
TC01004799.hg
UPI000013D3E4
XM_006711224
XM_011509308
XM_011509309
XM_011509310
XP_006711287
XP_011507610
XP_011507611
XP_011507612
Participant Of
output
input
Other forms of this molecule
ATF6 [endoplasmic reticulum membrane]
ATF6(420-670) [Golgi membrane]
ATF6 [Golgi membrane]
ATF6(380-419) [Golgi membrane]
ATF6(1-419) [Golgi membrane]
ATF6(1-380) [nucleoplasm]
Inferred To
ATF6(1-380) [cytosol] (Bos taurus)
ATF6(1-380) [cytosol] (Caenorhabditis elegans)
ATF6(1-380) [cytosol] (Canis familiaris)
ATF6(1-380) [cytosol] (Danio rerio)
ATF6(1-380) [cytosol] (Drosophila melanogaster)
ATF6(1-380) [cytosol] (Gallus gallus)
ATF6(1-380) [cytosol] (Mus musculus)
ATF6(1-380) [cytosol] (Rattus norvegicus)
ATF6(1-380) [cytosol] (Sus scrofa)
ATF6(1-380) [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
OpenTargets
GeneCards
PRO
Orphanet
Interactors (3)