Reactome | IRE1 binds IRE1 forming dimer

IRE1 binds IRE1 forming dimer

Stable Identifier

R-HSA-381109

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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The dissociation of the IRE1-alpha:BiP heterodimer liberates IRE1-alpha, which forms homodimers. Dimer formation is initiated by interaction between the N-terminal, luminal domains.

Literature References

PubMed ID	Title	Journal	Year
10835430	Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum Liu, CY, Schröder, M, Kaufman, RJ	J Biol Chem	2000
16973740	The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response Back, SH, Liu, CY, Kaufman, RJ, Peisach, D, Zhou, J, Xu, Z, Clark, RL	Proc Natl Acad Sci U S A	2006
11897784	The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain Wong, HN, Liu, CY, Kaufman, RJ, Schauerte, JA	J Biol Chem	2002
11069889	The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response Lee, K, Kaufman, RJ, Callaghan, B, Welihinda, A, Tirasophon, W	Genes Dev	2000