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DDIT3 [nucleoplasm]
Stable Identifier
R-HSA-381110
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CHOP, GADD153
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
ATF4 and a CEBP protein bind the TRIB3 promoter (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3:TRIB3 gene [nucleoplasm] (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
Expression of TRIB3 in response to stress (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3:TRIB3 gene [nucleoplasm] (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
Translation of DDIT3 (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
ATF4 and a CEBP protein bind the ATF5 promoter (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3:ATF5 gene [nucleoplasm] (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
ATF4 and a CEBP protein bind the TRIB3 promoter (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3:TRIB3 gene [nucleoplasm] (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
Expression of TRIB3 in response to stress (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3:TRIB3 gene [nucleoplasm] (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
Transcription of ATF5 (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3:ATF5 gene [nucleoplasm] (Homo sapiens)
ATF4:CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
Translation of DDIT3 (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)
Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell death genes (Homo sapiens)
BBC3 gene expression is stimulated by FOXO3,(FOXO1) (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y (Homo sapiens)
DDIT3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35638 DDIT3
Gene Names
DDIT3, CHOP, CHOP10, GADD153
Chain
chain:1-169
Reference Genes
BioGPS Gene:1649 DDIT3
COSMIC (genes):DDIT3 DDIT3
CTD Gene:1649 DDIT3
dbSNP Gene:1649 DDIT3
ENSEMBL:ENSG00000175197 DDIT3
ENSEMBL_homo_sapiens_GENE:ENSG00000175197.13 DDIT3
KEGG Gene (Homo sapiens):1649 DDIT3
Monarch:1649 DDIT3
NCBI Gene:1649 DDIT3
OMIM:126337 DDIT3
UCSC:P35638 DDIT3
Reference Transcript
RefSeq:NM_001195053.1 DDIT3
RefSeq:NM_001195057.1 DDIT3
RefSeq:NM_001195054.1 DDIT3
RefSeq:NM_004083.5 DDIT3
RefSeq:NM_001195055.1 DDIT3
Other Identifiers
11758198_s_at
11758347_s_at
1649
16766578
1842_at
209383_PM_at
209383_at
3458588
3458589
3458590
3458591
3458593
3458594
3458595
3458596
3458605
3458606
39420_at
7964460
A_23_P21134
GE60149
GE86844
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0001955
GO:0003677
GO:0003700
GO:0003714
GO:0005515
GO:0005634
GO:0005667
GO:0005694
GO:0005737
GO:0005768
GO:0005770
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006914
GO:0006915
GO:0006974
GO:0006983
GO:0006986
GO:0007049
GO:0007605
GO:0008140
GO:0009611
GO:0009948
GO:0010467
GO:0010506
GO:0012501
GO:0016055
GO:0023052
GO:0030154
GO:0030163
GO:0030968
GO:0031410
GO:0032689
GO:0032700
GO:0032713
GO:0032757
GO:0032993
GO:0034976
GO:0036119
GO:0036488
GO:0036499
GO:0036500
GO:0042594
GO:0042802
GO:0042803
GO:0043161
GO:0043226
GO:0043433
GO:0043522
GO:0043525
GO:0045454
GO:0045599
GO:0045662
GO:0045892
GO:0045893
GO:0045944
GO:0046982
GO:0048856
GO:0048870
GO:0050877
GO:0051091
GO:0051209
GO:0051726
GO:0051898
GO:0055065
GO:0055085
GO:0060840
GO:0061629
GO:0070059
GO:0072655
GO:0090090
GO:0090575
GO:0098772
GO:0120163
GO:0140110
GO:0140416
GO:0140467
GO:0140537
GO:1902237
GO:1904738
GO:1990442
GO:1990617
GO:1990622
GO:1990874
GO:2000016
GO:2001244
HMNXSV003024676
ILMN_1676984
PH_hs_0033101
TC12001625.hg
g13177717_3p_at
Participates
as an output of
Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)
Translation of DDIT3 (Homo sapiens)
as a member of
CEBPB,CEBPG,DDIT3 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y
(Homo sapiens)
BBC3 gene expression is stimulated by FOXO3,(FOXO1)
(Homo sapiens)
Cross References
RefSeq
NP_001181982.1
,
NP_001181984.1
,
NP_004074.2
,
NP_001181983.1
,
NP_001181986.1
OpenTargets
ENSG00000175197
ZINC - Substances
DDIT3_HUMAN
HPA
ENSG00000175197-DDIT3
GeneCards
P35638
ZINC target
P35638
Ensembl
ENST00000623876
,
ENST00000547303
,
ENST00000551116
,
ENSP00000448665
,
ENSP00000494844
,
ENSP00000447188
,
ENSP00000340671
,
ENST00000552740
,
ENST00000346473
,
ENSP00000447803
,
ENSG00000175197
PRO
P35638
Pharos - Targets
P35638
ZINC - Predictions - Purchasable
DDIT3_HUMAN
Orphanet
21734
HMDB Protein
HMDBP14618
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18847 ATF3
1
ATF3 [nucleoplasm]
(R-HSA-535543)
0.958
38
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.878
11
UniProt:Q16520 BATF
1
BATF [nucleoplasm]
(R-HSA-6789925)
0.847
8
UniProt:P53567 CEBPG
1
CEBPG [nucleoplasm]
(R-HSA-9644320)
0.831
7
UniProt:Q9NR55 BATF3
0.818
8
UniProt:P15408 FOSL2
0.774
6
UniProt:Q9BPX1 HSD17B14
1
HSD17B14 [cytosol]
(R-HSA-6810587)
0.764
6
UniProt:P18848 ATF4
2
ATF4 [cytosol]
(R-HSA-381084)
ATF4 [nucleoplasm]
(R-HSA-381016)
0.713
5
UniProt:P49715 CEBPA
1
CEBPA [nucleoplasm]
(R-HSA-381289)
0.713
5
UniProt:Q86SX3 TEDC1
0.659
3
UniProt:Q10586 DBP
1
DBP [nucleoplasm]
(R-HSA-879796)
0.646
4
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.625
5
UniProt:Q16649 NFIL3
1
NFIL3 [nucleoplasm]
(R-HSA-8878899)
0.623
2
UniProt:Q16534 HLF
0.623
3
UniProt:O43889 CREB3
7
CREB3(1-256) [nucleoplasm]
(R-HSA-8874190)
CREB3(1-256) [cytosol]
(R-HSA-8874135)
CREB3(1-291) [Golgi membrane]
(R-HSA-8874181)
CREB3(257-291) [Golgi membrane]
(R-HSA-8874207)
CREB3 [Golgi membrane]
(R-HSA-8874123)
CREB3(292-371) [Golgi membrane]
(R-HSA-8874173)
CREB3 [endoplasmic reticulum membrane]
(R-HSA-8874165)
0.623
2
UniProt:P15336 ATF2
2
ATF2 [nucleoplasm]
(R-HSA-450336)
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
0.623
2
UniProt:P17275 JUNB
1
JUNB [nucleoplasm]
(R-HSA-2186795)
0.623
2
UniProt:O14867 BACH1
5
BACH1 [nucleoplasm]
(R-HSA-9707688)
BACH1 [cytosol]
(R-HSA-9708429)
PolyUb-BACH1 [nucleoplasm]
(R-HSA-9708486)
p-Y483 BACH1 [nucleoplasm]
(R-HSA-9762202)
p-Y483 BACH1 [cytosol]
(R-HSA-9762206)
0.623
2
UniProt:Q15744 CEBPE
1
CEBPE [nucleoplasm]
(R-HSA-3234072)
0.592
3
UniProt:P17544 ATF7
0.59
2
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.59
2
UniProt:P17676 CEBPB
3
p-T235, S321-CEBPB [nucleoplasm]
(R-HSA-3857339)
p-T235-CEBPB [nucleoplasm]
(R-HSA-3857343)
CEBPB [nucleoplasm]
(R-HSA-381378)
0.59
3
UniProt:O60519 CRBL2
0.556
3
UniProt:P40454 PTPA1
0.556
3
UniProt:Q9BSW2 CRACR2A
2
CRACR2A [extracellular region]
(R-HSA-6806289)
CRACR2A [specific granule lumen]
(R-HSA-6799553)
0.556
3
UniProt:Q86VQ3 TXND2
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
IntAct:EBI-22391804 CCSB ORF ID
0.556
3
UniProt:Q9BTE3-2 MCMBP
0.556
3
UniProt:A5D8V6 VPS37C
1
VPS37C [endosome membrane]
(R-HSA-184438)
0.556
3
UniProt:O43508 TNFSF12
2
TNFSF12 [plasma membrane]
(R-HSA-5667154)
sTNFSF12 [extracellular region]
(R-HSA-5675974)
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q7Z589-5 EMSY
0.556
3
UniProt:Q8WYK2 JDP2
0.556
3
UniProt:Q99757 TXN2
2
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q6ICC9 RTL6
0.527
2
UniProt:Q13283 G3BP1
1
G3BP1 [cytosol]
(R-HSA-9729517)
0.524
2
UniProt:Q15154-3 PCM1
0.488
2
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