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Phosphorylated IRE1 dimer binds ADP
Stable Identifier
R-HSA-381116
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
Phosphorylated IRE1 dimer binds ADP (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylation of the C-terminal region causes a loop in the C-terminus to change position, enabling access to an ADP-binding pocket. Phosphorylated IRE1-alpha dimers bind ADP in preference to ATP.
Participants
Input
x 2
ADP [cytosol]
p-S724-IRE1 dimer [endoplasmic reticulum membrane]
(Homo sapiens)
Output
p-S724-IRE1 dimer:ADP [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an event of
IRE1alpha activates chaperones (Homo sapiens)
Inferred From
Phosphorylated Ire1 Dimer Binds ADP (Saccharomyces cerevisiae)
Authored
May, B (2009-06-02)
Reviewed
Gillespie, ME (2008-12-02)
D'Eustachio, P (2008-12-02)
Matthews, L (2008-12-02)
Urano, F (2010-04-30)
Created
May, B (2008-11-19)
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