MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)

Stable Identifier
R-HSA-381135
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once in the Golgi, ATF6-alpha undergoes two sequential proteolytic cleavages. S1P catalyzes the first of these, probably cleaving the ATF6-alpha polypeptide between residues 418 and 419 based on homology with known S1P cleavage sites in other proteins.

Literature References
PubMed ID Title Journal Year
15299016 Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6

Shen, J, Prywes, R

J Biol Chem 2004
10564271 Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

Haze, K, Yoshida, H, Yanagi, H, Yura, T, Mori, K

Mol Biol Cell 1999
11163209 ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

Ye, J, Rawson, RB, Komuro, R, Chen, X, Davé, UP, Prywes, R, Brown, MS, Goldstein, JL

Mol Cell 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MBTPS1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Created