Reactome: A Curated Pathway Database

ATF6 (ATF6-alpha) activates chaperone genes

Stable Identifier
R-HSA-381183
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription factor NF-Y, which binds the sequence CCAAT in the ERSEs, and together the two factors activate transcription of ER stress-responsive genes. Evidence from overexpression and knockdowns indicates that ATF6-alpha is a potent activator but its homolog ATF6-beta is not and ATF6-beta may actually reduce expression of ER stress proteins.

Literature References
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