ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi

Stable Identifier
R-HSA-381186
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The association between ATF6-alpha and BiP causes ATF6-alpha to be retained in the endoplasmic reticulum (ER). Once dissociated from BiP, the two Golgi Localization Sequences on ATF6-alpha are exposed and ATF6-alpha transits from the ER to the Golgi Apparatus.
Literature References
PubMed ID Title Journal Year
15657421 Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response

Lippincott-Schwartz, J, Shen, J, Prywes, R, Snapp, EL

Mol Cell Biol 2005
12110171 ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

Hendershot, L, Chen, X, Shen, J, Prywes, R

Dev Cell 2002
11821395 The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

Chen, X, Shen, J, Prywes, R

J Biol Chem 2002
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