Formation of PPARG:RXRA heterodimer (ARF6 complex)

Stable Identifier
R-HSA-381262
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PPARG binds the Retinoic acid X Receptor RXRA to form a heterodimer that has transcriptional acivation activity. The complex was initially called ARF6 when discovered. PPARG binds RXRA via the C-terminus and AF-2 regions of PPARG.

Literature References
PubMed ID Title Journal Year
17980149 Effect of heterodimer partner RXRalpha on PPARgamma activation function-2 helix in solution

Lu, J, Chen, M, Stanley, SE, Li, E

Biochem Biophys Res Commun 2008
17011499 Transcriptional control of adipocyte formation

Farmer, SR

Cell Metab 2006
19043829 Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

Chandra, V, Huang, P, Hamuro, Y, Raghuram, S, Wang, Y, Burris, TP, Rastinejad, F

Nature 2008
Participants
Participant Of
Orthologous Events
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Reviewed
Created