PPARG:RXRA heterodimer binds to PPARG corepressors

Stable Identifier
R-HSA-381290
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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PPARG:RXRA heterodimer binds to PPARG corepressors
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The PPARG:RXRA heterodimer binds specific the PPRE element, two 6-bp DR-1 motifs separated by 1 nucleotide, in the promoters of target genes such as aP2/FABP4 even in the absence of fatty acid ligands that activate PPARG. When activating ligands of PPARG are absent PPARG:RXRA recruits corepressors such as NCoR2(SMRT), NCoR, and HDAC3 to maintain the target gene in an inactive state.

Literature References
PubMed ID Title Journal Year
8970730 Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology

Lemberger, T, Desvergne, B, Wahli, W

Annu Rev Cell Dev Biol 1996
17011499 Transcriptional control of adipocyte formation

Farmer, SR

Cell Metab 2006
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Inferred From
Pparg:Rxra heterodimer binds to PPARG corepressors (Mus musculus)
Authored
May, B  (2009-05-15)
Reviewed
D'Eustachio, P  (2009-05-27)
Sethi, JK  (2011-02-10)
Created
May, B  (2008-11-20)
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