PPARG:RXRA heterodimer binds to PPARG corepressors

Stable Identifier
R-HSA-381290
Type
Reaction [binding]
Species
Homo sapiens
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The PPARG:RXRA heterodimer binds specific the PPRE element, two 6-bp DR-1 motifs separated by 1 nucleotide, in the promoters of target genes such as aP2/FABP4 even in the absence of fatty acid ligands that activate PPARG. When activating ligands of PPARG are absent PPARG:RXRA recruits corepressors such as NCoR2(SMRT), NCoR, and HDAC3 to maintain the target gene in an inactive state.

Literature References
PubMed ID Title Journal Year
8970730 Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology

Lemberger, T, Desvergne, B, Wahli, W

Annu Rev Cell Dev Biol 1996
17011499 Transcriptional control of adipocyte formation

Farmer, SR

Cell Metab 2006
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