Reactome | IGFBP4 [extracellular region]

IGFBP4 [extracellular region]

Stable Identifier

R-HSA-381421

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Insulin-like Growth Factor Binding Protein-4, IBP4_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:D3DTS7

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External Reference Information

External Reference

UniProt:P22692 IGFBP4

Gene Names

IGFBP4, IBP4

Chain

signal peptide:1-21, chain:22-258

Reference Genes

BioGPS Gene:3487 IGFBP4

COSMIC (genes):IGFBP4 IGFBP4

CTD Gene:3487 IGFBP4

dbSNP Gene:3487 IGFBP4

ENSEMBL:ENSG00000141753 IGFBP4

HGNC:5473 IGFBP4

KEGG Gene (Homo sapiens):3487 IGFBP4

Monarch:3487 IGFBP4

NCBI Gene:3487 IGFBP4

OMIM:146733 IGFBP4

UCSC:P22692 IGFBP4

Reference Transcript

RefSeq:NM_001552.2 IGFBP4

Other Identifiers

0002810364

11715463_s_at

11715464_x_at

11715465_at

11749616_s_at

16834091

1737_s_at

201508_at

3487

3721011

3721012

3721028

3721030

3721032

3721033

3721034

3721037

39781_at

74566_at

8007100

89974_at

A_14_P139973

A_24_P382187

GE81040

GE86806

GO:0001558

GO:0003674

GO:0005102

GO:0005515

GO:0005520

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005975

GO:0006464

GO:0006950

GO:0006954

GO:0007165

GO:0007267

GO:0008150

GO:0008283

GO:0010906

GO:0019838

GO:0031994

GO:0031995

GO:0040007

GO:0040008

GO:0043226

GO:0043410

GO:0043567

GO:0043568

GO:0043687

GO:0044267

GO:0044281

GO:0044342

GO:0090090

HMNXSV003003979

ILMN_1665865

ILMN_1844829

M62403_s_at

PH_hs_0000202

TC17000499.hg

g10835020_3p_s_at

Participates

as an input of

IGFBP4 binds IGF forming IGF:IGFBP4 (Homo sapiens)

as a component of

IGF:IGFBP4 [extracellular region] (Homo sapiens)

Other forms of this molecule

IGFBP4(157-237) [extracellular region]

IGFBP4(22-156) [extracellular region]

IGFBP4 [endoplasmic reticulum lumen]

p-IGFBP4 [endoplasmic reticulum lumen]

Inferred To

Igfbp4 [extracellular region] (Mus musculus)

Igfbp4 [extracellular region] (Rattus norvegicus)

IGFBP4 [extracellular region] (Canis familiaris)

IGFBP4 [extracellular region] (Gallus gallus)

IGFBP4 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001543.2

OpenTargets

ENSG00000141753

HPA

ENSG00000141753-IGFBP4

ZINC - Substances

IBP4_HUMAN

GeneCards

P22692

Ensembl

ENSG00000141753, ENST00000269593, ENSP00000269593

ZINC target

P22692

PRO

P22692

PDB

2DSP, 2DSR, 1WQJ, 2DSQ

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05019 IGF1	3	IGF1 [platelet alpha granule lumen] (R-HSA-139878) IGF1 [extracellular region] (R-HSA-57187) IGF1 [extracellular region] (R-HSA-2404178)	0.76	7
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P54252 ATXN3	2	ATXN3 [cytosol] (R-HSA-5625607) ATXN3 [nucleoplasm] (R-HSA-6783285)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:O14656 TOR1A	1	TOR1A [cytosol] (R-HSA-8862858)	0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:D3DTS7 D3DTS7			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:P28799 GRN	2	GRN [extracellular region] (R-HSA-6806217) GRN [azurophil granule lumen] (R-HSA-6799168)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:P06396 GSN	7	GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P22607 FGFR3	40	FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) pY-FGFR3 [plasma membrane] (R-HSA-2038368) p-6Y-FGFR3 K650Q [plasma membrane] (R-HSA-2032962) p-6Y-FGFR3 K650N [plasma membrane] (R-HSA-2032961) p-6Y-FGFR3 K650E [plasma membrane] (R-HSA-2032952) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853147) p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853155) p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853145) p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853129) p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853151) p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853128) FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127)	0.556	3

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