Reactome | Plasmin proteolyzes IGF:IGFBP-3:ALS

Plasmin proteolyzes IGF:IGFBP-3:ALS

Stable Identifier

R-HSA-381461

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

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Plasmin cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 124 and 125 and between amino acids 187 and 188, releasing IGF.

Literature References

PubMed ID	Title	Journal	Year
7588299	Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3) Angelloz-Nicoud, P, Binoux, M	Endocrinology	1995
7527330	Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells Lalou, C, Silve, C, Rosato, R, Segovia, B, Binoux, M	Endocrinology	1994
8964575	Isolation and characterization of proteolytic fragments of insulin-like growth factor-binding protein-3 Lalou, C, Lassarre, C, Binoux, M	Horm Res	1996
12466191	Cellular actions of the insulin-like growth factor binding proteins Firth, SM, Baxter, RC	Endocr Rev	2002
10990447	Prostate carcinoma (PC-3) cell proliferation is stimulated by the 22-25-kDa proteolytic fragment (1-160) and inhibited by the 16-kDa fragment (1-95) of recombinant human insulin-like growth factor binding protein-3 Angelloz-Nicoud, P, Lalou, C, Binoux, M	Growth Horm IGF Res	1998
17047378	The role of insulin-like growth factor binding proteins Holly, J, Perks, C	Neuroendocrinology	2006
8894645	Recombinant human insulin-like growth factor (IGF) binding protein-3 stimulates prostate carcinoma cell proliferation via an IGF-dependent mechanism. Role of serine proteases Angelloz-Nicoud, P, Harel, L, Binoux, M	Growth Regul	1996
8817670	Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth Rajah, R, Katz, L, Nunn, S, Solberg, P, Beers, T, Cohen, P	Prog Growth Factor Res	1995
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
11739083	IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis Booth, BA, Boes, M, Dake, BL, Knudtson, KL, Bar, RS	Am J Physiol Endocrinol Metab	2002