Reactome | IGFBP1 binds IGF forming IGF:IGFBP1

IGFBP1 binds IGF forming IGF:IGFBP1

Stable Identifier

R-HSA-381487

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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IGFBP 1 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 1. IGFBP 1 is enriched in amniotic fluid and is produced in the liver under control of insulin (insulin suppresses production). IGFBP 1 acts to stimulate IGF function. It is unknown which if any protease degrades IGFBP 1.

Literature References

PubMed ID	Title	Journal	Year
7543116	Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation Hall, K, Skakkebaek, NE, Müller, J, Blum, WF, Michaelsen, KF, Bang, P, Dalgaard, P, Juul, A	J Clin Endocrinol Metab	1995
7683646	Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 Hsieh, S, Sakano, K, Rechler, MM, Fujiwara, H, Bach, LA, Perdue, JF	J Biol Chem	1993
12466191	Cellular actions of the insulin-like growth factor binding proteins Baxter, RC, Firth, SM	Endocr Rev	2002
17047378	The role of insulin-like growth factor binding proteins Perks, C, Holly, J	Neuroendocrinology	2006
7689487	Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting Savage, MO, Holly, JM, Frost, VJ, Cianfarani, S	Experientia	1993
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
9733769	The insulin-like growth factor (IGF)binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysis Nilsson, B, Kördel, J, Andersson, G, Jansson, M, Uhlén, M	J Biol Chem	1998
8781553	Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography Rechler, MM, Bach, LA	Biochim Biophys Acta	1996
7519608	Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes Arai, T, Busby W, Jr, Parker, A, Clemmons, DR	J Biol Chem	1994