Cathepsin G proteolyzes IGF:IGFBP3:ALS

Stable Identifier
R-HSA-381500
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Cathepsin G proteolyzes IGF:IGFBP3:ALS
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Cathepsin G cleaves IGFBP-3 between amino acids 168 and 169 and between amino acids 226 and 227, releasing IGF from the IGF:IGFBP-3:ALS Complex.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of Cathepsin G [plasma membrane]

Physical Entity
Cathepsin G [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Cathepsin G proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)
Authored
Gopinathrao, G  (2008-11-20)
May, B  (2008-11-20)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Created
May, B  (2008-11-20)
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