Reactome | IGFBP6 binds IGF forming IGF:IGFBP6

IGFBP6 binds IGF forming IGF:IGFBP6

Stable Identifier

R-HSA-381503

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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IGFBP-6 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP-6. IGFBP-6 binds IGF II with greater affinity than IGF I.

Literature References

PubMed ID	Title	Journal	Year
7683646	Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 Hsieh, S, Sakano, K, Rechler, MM, Fujiwara, H, Bach, LA, Perdue, JF	J Biol Chem	1993
12466191	Cellular actions of the insulin-like growth factor binding proteins Baxter, RC, Firth, SM	Endocr Rev	2002
17047378	The role of insulin-like growth factor binding proteins Perks, C, Holly, J	Neuroendocrinology	2006
15525596	Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding Leeding, KS, Headey, SJ, Norton, RS, Bach, LA	J Mol Endocrinol	2004
15308688	C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II Brasier, G, Headey, SJ, Norton, RS, Bach, LA, Kantharidis, P, Yao, S, Keizer, DW	Mol Endocrinol	2004
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
7689487	Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting Savage, MO, Holly, JM, Frost, VJ, Cianfarani, S	Experientia	1993
8781553	Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography Rechler, MM, Bach, LA	Biochim Biophys Acta	1996
7525263	Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts Hsieh, S, Brown, AL, Rechler, MM, Bach, LA	Endocrinology	1994
10951195	O-glycosylation of insulin-like growth factor (IGF) binding protein-6 maintains high IGF-II binding affinity by decreasing binding to glycosaminoglycans and susceptibility to proteolysis Neumann, GM, Marinaro, JA, Leeding, KS, Russo, VC, Bach, LA	Eur J Biochem	2000