Reactome | IGFBP3(125-187) [extracellular region]

IGFBP3(125-187) [extracellular region]

Stable Identifier

R-HSA-381507

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

IGFBP-3 (125-187 fragment)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P17936 IGFBP3

Gene Names

IGFBP3, IBP3

Chain

signal peptide:1-27, chain:28-291

Reference Genes

BioGPS Gene:3486 IGFBP3

COSMIC (genes):IGFBP3 IGFBP3

CTD Gene:3486 IGFBP3

dbSNP Gene:3486 IGFBP3

ENSEMBL:ENSG00000146674 IGFBP3

HGNC:5472 IGFBP3

KEGG Gene (Homo sapiens):3486 IGFBP3

Monarch:3486 IGFBP3

NCBI Gene:3486 IGFBP3

OMIM:146732 IGFBP3

UCSC:P17936 IGFBP3

Reference Transcript

Other Identifiers

0006450411

11721135_s_at

11749912_x_at

1586_at

17057478

210095_s_at

212143_s_at

3049293

3049294

3049295

3049296

3049297

3049299

3049302

3049303

3049304

3049306

3049307

3049308

3049309

3049310

3049311

3486

37319_at

8139488

A_23_P215634

GE59912

GO:0001558

GO:0001649

GO:0001933

GO:0001968

GO:0003674

GO:0005515

GO:0005520

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005783

GO:0005788

GO:0005975

GO:0006464

GO:0006468

GO:0006915

GO:0007165

GO:0008150

GO:0008160

GO:0008219

GO:0008283

GO:0008285

GO:0009968

GO:0010906

GO:0014912

GO:0016942

GO:0019838

GO:0030154

GO:0030234

GO:0031994

GO:0031995

GO:0032991

GO:0040007

GO:0040008

GO:0040011

GO:0042567

GO:0042981

GO:0043065

GO:0043167

GO:0043226

GO:0043410

GO:0043567

GO:0043568

GO:0043666

GO:0043687

GO:0044267

GO:0044281

GO:0044342

GO:0045663

GO:0046872

GO:0048662

GO:0048856

GO:0048870

Hs.77326.1.S2_3p_a_at

ILMN_1746085

ILMN_2396875

M35878_at

PH_hs_0036058

TC07001355.hg

g183115_3p_a_at

Participant Of

output

Plasmin proteolyzes IGF:IGFBP-3:ALS

Other forms of this molecule

IGFBP3 [extracellular region]

IGFBP3 [endoplasmic reticulum lumen]

p-IGFBP3 [endoplasmic reticulum lumen]

IGFBP3(125-233) [extracellular region]

IGFBP3(28-124) [extracellular region]

IGFBP3(234-291) [extracellular region]

IGFBP3(188-291) [extracellular region]

IGFBP3(28-168) [extracellular region]

IGFBP3(227-291) [extracellular region]

IGFBP3(169-226) [extracellular region]

IGFBP3(127-291) [extracellular region]

IGFBP3(28-126) [extracellular region]

IGFBP3(291-187) [extracellular region]

IGFBP3(28-186) [extracellular region]

Inferred To

Igfbp3 [extracellular region] (Rattus norvegicus)

igfbp3 [extracellular region] (Danio rerio)

Cross References

RefSeq

XP_016867641.1, NP_001013416.1, NP_000589.2

OpenTargets

ENSG00000146674

HPA

ENSG00000146674-IGFBP3

GeneCards

P17936

ZINC - Substances

IBP3_HUMAN

Ensembl

ENST00000275521, ENSG00000146674, ENST00000381083, ENSP00000275521, ENSP00000370473

ZINC target

P17936

PRO

P17936

ZINC - Predictions - Purchasable

IBP3_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86XT9 TMEM219	1	TMEM219 [plasma membrane] (R-HSA-6800018)	0.66	8
hyaluronic acid [ChEBI:16336]	3	HUA [extracellular region] (R-ALL-1297302) HUA [endocytic vesicle lumen] (R-ALL-2239419) HUA [cytosol] (R-ALL-877209)	0.611	8
UniProt:Q8IVG9 MT-RNR2	1	MT-RNR2 [extracellular region] (R-HSA-444568)	0.602	7
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.576	3
UniProt:P78527 PRKDC	4	PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.499	2

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