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IGFBP3(125-187) [extracellular region]
Stable Identifier
R-HSA-381507
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
IGFBP-3 (125-187 fragment)
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)
IGFBP3(125-187) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17936 IGFBP3
Gene Names
IGFBP3, IBP3
Chain
signal peptide:1-27, chain:28-291
Reference Genes
BioGPS Gene:3486 IGFBP3
COSMIC (genes):IGFBP3 IGFBP3
CTD Gene:3486 IGFBP3
dbSNP Gene:3486 IGFBP3
ENSEMBL:ENSG00000146674 IGFBP3
HGNC:5472 IGFBP3
KEGG Gene (Homo sapiens):3486 IGFBP3
Monarch:3486 IGFBP3
NCBI Gene:3486 IGFBP3
OMIM:146732 IGFBP3
UCSC:P17936 IGFBP3
Reference Transcript
RefSeq:NM_000598.4 IGFBP3
RefSeq:XM_017012152.1 IGFBP3
RefSeq:NM_001013398.1 IGFBP3
Other Identifiers
0006450411
10360
11721135_s_at
11749912_x_at
1586_at
17057478
210095_s_at
212143_s_at
3049293
3049294
3049295
3049296
3049297
3049299
3049302
3049303
3049304
3049306
3049307
3049308
3049309
3049310
3049311
3486
37319_at
8139488
A6XND0
A6XND1
A_23_P215634
AAA52541
AAA52706
AAH00013
AAH18962
AAH64987
AAS07554
ABB96247
AC091524
B3KWK7
BC000013
BC018962
BC064987
C9JMX4
CAA46087
CAB010360
CCDS34632
CCDS5505
CH236958
CH471128
DQ301819
EAL23801
EAW61028
EAW61029
ENSG00000146674
ENSP00000275521
ENSP00000370473
ENST00000275521
ENST00000275521.10
ENST00000381083
EntrezGene:3486
EntrezGene:IGFBP3
g183115_3p_a_at
GE59912
GO:0001558
GO:0001649
GO:0001933
GO:0001968
GO:0003674
GO:0005515
GO:0005520
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005783
GO:0005788
GO:0005975
GO:0006464
GO:0006468
GO:0006915
GO:0007165
GO:0008150
GO:0008160
GO:0008219
GO:0008283
GO:0008285
GO:0009968
GO:0010906
GO:0014912
GO:0016942
GO:0019838
GO:0030154
GO:0030234
GO:0031994
GO:0031995
GO:0032991
GO:0040007
GO:0040008
GO:0040011
GO:0042567
GO:0042981
GO:0043065
GO:0043167
GO:0043226
GO:0043410
GO:0043567
GO:0043568
GO:0043666
GO:0043687
GO:0044267
GO:0044281
GO:0044342
GO:0045663
GO:0046872
GO:0048662
GO:0048856
GO:0048870
HGNC:5472
Hs.77326.1.S2_3p_a_at
IGFBP3
IGFBP3-201
IGFBP3-202
ILMN_1746085
ILMN_2396875
IPR000716
IPR000867
IPR009030
IPR009168
IPR012211
IPR017891
IPR022321
IPR036857
M31159
M35878
M35878_at
MIM:146732
NM_000598
NM_001013398
NP_000589
NP_001013416
PF00086
PF00219
PH_hs_0036058
PR01976
PR01979
SM00121
SM00211
TC07001355.hg
UPI000013DA64
UPI00004F8E1F
X64875
Participant Of
output
Plasmin proteolyzes IGF:IGFBP-3:ALS
Other forms of this molecule
IGFBP3(28-186) [extracellular region]
IGFBP3(291-187) [extracellular region]
IGFBP3(28-126) [extracellular region]
IGFBP3(127-291) [extracellular region]
IGFBP3(169-226) [extracellular region]
IGFBP3(227-291) [extracellular region]
IGFBP3(28-168) [extracellular region]
IGFBP3(188-291) [extracellular region]
IGFBP3(234-291) [extracellular region]
IGFBP3(28-124) [extracellular region]
IGFBP3(125-233) [extracellular region]
IGFBP3 [extracellular region]
p-IGFBP3 [endoplasmic reticulum lumen]
IGFBP3 [endoplasmic reticulum lumen]
Inferred To
IGFBP3(125-187) [extracellular region] (Danio rerio)
IGFBP3(125-187) [extracellular region] (Rattus norvegicus)
Cross References
RefSeq
XP_016867641.1
,
NP_000589.2
,
NP_001013416.1
OpenTargets
ENSG00000146674
ZINC - Substances
IBP3_HUMAN
GeneCards
P17936
ZINC target
P17936
PRO
P17936
ZINC - Predictions - Purchasable
IBP3_HUMAN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86XT9 TMEM219
1
TMEM219 [plasma membrane]
(R-HSA-6800018)
0.66
8
hyaluronic acid [ChEBI:16336]
3
HUA [extracellular region]
(R-ALL-1297302)
HUA [endocytic vesicle lumen]
(R-ALL-2239419)
HUA [cytosol]
(R-ALL-877209)
0.611
8
UniProt:Q8IVG9 MT-RNR2
1
MT-RNR2 [extracellular region]
(R-HSA-444568)
0.602
7
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.576
3
UniProt:P78527 PRKDC
4
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [nucleoplasm]
(R-HSA-62161)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.499
2
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