PAAP-A proteolyzes IGF:IGFBP4

Stable Identifier
R-HSA-381518
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Pregnancy associated Plasma Protein A (PPAP-A) cleaves IGFBP-4 in the IGF:IGFBP-4 Complex between amino acids 156 and 157, releasing IGF.
Literature References
PubMed ID Title Journal Year
17249697 Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy-associated plasma protein-A

Oxvig, C, Gyrup, C

Biochemistry 2007
12466191 Cellular actions of the insulin-like growth factor binding proteins

Baxter, RC, Firth, SM

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Perks, C, Holly, J

Neuroendocrinology 2006
10077652 The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A

Conover, CA, Sottrup-Jensen, L, Yates, JR 3rd, Overgaard, MT, Lawrence, JB, Oxvig, C, Gleich, GJ, Hays, LG

Proc Natl Acad Sci U S A 1999
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
17312271 Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5

Andersen, MH, Kjaer-Sorensen, K, Oxvig, C, Laursen, LS

Mol Endocrinol 2007
12241545 Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis

Conover, CA, Sottrup-Jensen, L, Overgaard, MT, Boldt, HB, Oxvig, C, Laursen, LS, Hopmann, KH, Nielsen, CG, Giudice, LC

Biochem J 2002
11158056 Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro

Mohan, S, Sexton, C, Baylink, DJ, Byun, D, Qin, X, Yoo, M

J Clin Endocrinol Metab 2001
10898936 Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease

Lau, KH, Mohan, S, Baylink, DJ, Byun, D, Qin, X

Arch Biochem Biophys 2000
12904166 IGF-binding protein-4: biochemical characteristics and functional consequences

Wolf, E, Lahm, H, Zhou, R, Hoeflich, A, Diehl, D

J Endocrinol 2003
Participants
Participates
Catalyst Activity

metalloendopeptidase activity of PAPPA,PAPPA2 [extracellular region]

Orthologous Events
Reviewed
Created
Cite Us!