G Protein trimer formation (olfactory)

Stable Identifier
R-HSA-381749
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of intracellular second messengers. GPCRs activate the G-proteins, which consist of an alpha-subunit that binds and hydrolyses guanosine triphosphate (GTP), a beta and a gamma subunit.

Literature References
PubMed ID Title Journal Year
14983052 The human olfactory receptor gene family

Malnic, B, Godfrey, PA, Buck, LB

Proc Natl Acad Sci U S A 2004
17873857 Genetic variation in a human odorant receptor alters odour perception

Keller, A, Zhuang, H, Chi, Q, Vosshall, LB, Matsunami, H

Nature 2007
9459443 Mice deficient in G(olf) are anosmic

Belluscio, L, Gold, GH, Nemes, A, Axel, R

Neuron 1998
1840504 A novel multigene family may encode odorant receptors: a molecular basis for odor recognition

Buck, L, Axel, R

Cell 1991
18043707 Heterotrimeric G protein activation by G-protein-coupled receptors

Oldham, WM, Hamm, HE

Nat Rev Mol Cell Biol 2008
17973576 Genetic elucidation of human hyperosmia to isovaleric acid

Menashe, I, Abaffy, T, Hasin, Y, Goshen, S, Yahalom, V, Luetje, CW, Lancet, D

PLoS Biol 2007
17509148 Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray

Zhang, X, De la Cruz, O, Pinto, JM, Nicolae, D, Firestein, S, Gilad, Y

Genome Biol 2007
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