Olfactory Receptor - G Protein olfactory trimer complex formation

Stable Identifier
R-HSA-381750
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Olfactory receptors (ORs) have diverse protein sequences but can be assigned to subfamilies on the basis of sequence relationships. Odorants and pheromones bind to these seven transmembrane domain G-protein-coupled receptors that permit signal transduction. These receptors are encoded by large multigene families that evolved in mammal species in function of specific olfactory needs. Members of the same subfamily have related sequences and are likely to recognize structurally related odorants.
Of the 960 human OR genes and pseudogenes, there is experimental evidence which indicates that at least 437 actually are expressed in human olfactory epithelium; this includes 357 OR genes, and 80 OR pseudogenes (Zhang, 2007). These 357 olfactory-expressed OR genes are therefore expected to be functional in the Olfactory Signaling Pathway, and to interact directly with human G alpha olf in human olfactory cells.

(Note: A subset of 200 of these 357 OR genes are shown as components of OR-G Protein reaction. The others will be added to Reactome later.)

Literature References
PubMed ID Title Journal Year
14983052 The human olfactory receptor gene family

Malnic, B, Godfrey, PA, Buck, LB

Proc Natl Acad Sci U S A 2004
17873857 Genetic variation in a human odorant receptor alters odour perception

Keller, A, Zhuang, H, Chi, Q, Vosshall, LB, Matsunami, H

Nature 2007
9459443 Mice deficient in G(olf) are anosmic

Belluscio, L, Gold, GH, Nemes, A, Axel, R

Neuron 1998
1840504 A novel multigene family may encode odorant receptors: a molecular basis for odor recognition

Buck, L, Axel, R

Cell 1991
18043707 Heterotrimeric G protein activation by G-protein-coupled receptors

Oldham, WM, Hamm, HE

Nat Rev Mol Cell Biol 2008
17973576 Genetic elucidation of human hyperosmia to isovaleric acid

Menashe, I, Abaffy, T, Hasin, Y, Goshen, S, Yahalom, V, Luetje, CW, Lancet, D

PLoS Biol 2007
17509148 Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray

Zhang, X, De la Cruz, O, Pinto, JM, Nicolae, D, Firestein, S, Gilad, Y

Genome Biol 2007
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