Translocation of PDGF from ER to Golgi

Stable Identifier
R-HSA-382053
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

All the newly synthesized PDGF chains are dimerized in the ER and thereafter transferred to the Golgi complex for proteolytic processing. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD.

Literature References
PubMed ID Title Journal Year
15207811 The PDGF family: four gene products form five dimeric isoforms

Fredriksson, L, Li, H, Eriksson, U

Cytokine Growth Factor Rev 2004
1639841 PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly

Ostman, A, Thyberg, J, Westermark, B, Heldin, CH

J Cell Biol 1992
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created