Extracellular processing of novel PDGFs

Stable Identifier
R-HSA-382061
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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During the extracellular proteolytic activation of PDGF-C and PDGF-D chains, the CUB domains is removed and plasmin protease has been shown to proteolytically cleave within the hinge regions, and thus releasing the corresponding growth factor domains. In addition the protease tissue-type plasminogen activator (tPA) is also involved in the activation of PDGF-CC but not able to cleave and activate PDGF-DD.

Literature References
PubMed ID Title Journal Year
15207811 The PDGF family: four gene products form five dimeric isoforms

Fredriksson, L, Li, H, Eriksson, U

Cytokine Growth Factor Rev 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of serine-type endopeptidases involved in novel PDGF processing [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created