ABCA7:Apo1A-mediated phospholipid efflux

Stable Identifier
R-HSA-382553
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids and may have a possible role in cellular phospholipid metabolism in peripheral tissues. Like many other ABC-transporters, the exact role of ABCA7 is waiting to be elucidated.

Literature References
PubMed ID Title Journal Year
14570867 Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein

Abe-Dohmae, S, Ikeda, Y, Matsuo, M, Hayashi, M, Okuhira, K, Ueda, K, Yokoyama, S

J Biol Chem 2004
11095984 Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene

Kaminski, WE, Piehler, A, Schmitz, G

Biochem Biophys Res Commun 2000
12509503 Role of ABC transporters in secretion of cholesterol from liver into bile

Small, DM

Proc Natl Acad Sci U S A 2003
14592415 Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release

Ikeda, Y, Abe-Dohmae, S, Munehira, Y, Aoki, R, Kawamoto, S, Furuya, A, Shitara, K, Amachi, T, Kioka, N, Matsuo, M, Yokoyama, S, Ueda, K

Biochem Biophys Res Commun 2003
12917409 ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

Wang, N, Lan, D, Gerbod-Giannone, M, Linsel-Nitschke, P, Jehle, AW, Chen, W, Martinez, LO, Tall, AR

J Biol Chem 2003
10873640 Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)

Kaminski, WE, Orsó, E, Diederich, W, Klucken, J, Drobnik, W, Schmitz, G

Biochem Biophys Res Commun 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phospholipid transporter activity of ABCA7-1:ApoA1 complex [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created