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PELP1 [nucleoplasm]
Stable Identifier
R-HSA-3826531
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proline-, glutamic acid- and leucine-rich protein 1, PELP1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Homo sapiens)
Rix1 complex [nucleoplasm] (Homo sapiens)
PELP1 [nucleoplasm] (Homo sapiens)
32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Homo sapiens)
Rix1 complex [nucleoplasm] (Homo sapiens)
PELP1 [nucleoplasm] (Homo sapiens)
32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3 [nucleoplasm] (Homo sapiens)
Rix1 complex [nucleoplasm] (Homo sapiens)
PELP1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Expression (Homo sapiens)
EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)
PELP1 [nucleoplasm] (Homo sapiens)
PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
PELP1 [nucleoplasm] (Homo sapiens)
HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)
PELP1 [nucleoplasm] (Homo sapiens)
PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
PELP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IZL8 PELP1
Gene Names
PELP1, HMX3, MNAR
Chain
initiator methionine:, chain:2-1130
Reference Genes
BioGPS Gene:27043 PELP1
COSMIC (genes):HMX3 PELP1
COSMIC (genes):PELP1 PELP1
CTD Gene:27043 PELP1
dbSNP Gene:27043 PELP1
ENSEMBL:ENSG00000141456 PELP1
HGNC:30134 PELP1
KEGG:hsa:27043 PELP1
Monarch:27043 PELP1
NCBI Gene:27043 PELP1
OMIM:609455 PELP1
UCSC:Q8IZL8 PELP1
Reference Transcript
RefSeq:NM_001278241.1 PELP1
RefSeq:NM_014389.2 PELP1
Other Identifiers
11718835_x_at
11750608_x_at
16840087
215354_3p_s_at
215354_PM_s_at
215354_s_at
217651_PM_at
217651_at
27043
2771027
2979632
32455_s_at
3742235
3742237
3742238
3742240
3742241
3742242
3742243
3742244
3742245
3742246
3742247
3742248
3742249
3742250
3742251
3742252
3742253
3742254
3742255
3742256
3742257
3742258
3742259
3742260
3742261
3742262
3742263
3742264
3742266
3742267
3742268
3742269
3742270
3742271
3742275
3742276
3742278
3742279
3742280
3742281
8011692
A_33_P3375673
A_33_P3659808
GE492459
GE63211
GO:0000791
GO:0003682
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006355
GO:0006364
GO:0032183
GO:0043226
GO:0045944
GO:0071339
GO:0071391
HMNXSV003005153
HMNXSV003051055
Hs.274149.1.A1_3p_a_at
Hs.274149.1.A1_3p_x_at
Hs.297765.0.S1_3p_at
ILMN_1728684
PH_hs_0024791
TC17001028.hg
Participates
as a component of
Rix1 complex [nucleoplasm] (Homo sapiens)
PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
as an input of
EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)
Inferred To
Ghost homologue of PELP1 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of PELP1 [nucleoplasm]
(Danio rerio)
Ghost homologue of PELP1 [nucleoplasm]
(Gallus gallus)
PELP1 [nucleoplasm]
(Bos taurus)
PELP1 [nucleoplasm]
(Canis familiaris)
PELP1 [nucleoplasm]
(Dictyostelium discoideum)
PELP1 [nucleoplasm]
(Sus scrofa)
pelp1 [nucleoplasm]
(Xenopus tropicalis)
rix1 [nucleoplasm]
(Schizosaccharomyces pombe)
Pelp1 [nucleoplasm]
(Mus musculus)
Pelp1 [nucleoplasm]
(Rattus norvegicus)
RIX1 [nucleoplasm]
(Saccharomyces cerevisiae)
Dmel\CG33217 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001265170.1
,
NP_055204.3
ENSEMBL
ENST00000572293
,
ENSP00000460300
,
ENST00000574876
,
ENSP00000461625
OpenTargets
ENSG00000141456
HPA
ENSG00000141456-PELP1
PRO
Q8IZL8
Pharos - Targets
Q8IZL8
GlyGen
Q8IZL8
PDB
8FL2
,
8FL4
,
8FL3
,
7UWF
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BV38 WDR18
1
WDR18 [nucleoplasm]
(R-HSA-3826598)
0.903
18
UniProt:Q9H4L4 SENP3
1
SENP3 [nucleoplasm]
(R-HSA-2984296)
0.799
10
UniProt:Q9NXF1 TEX10
1
TEX10 [nucleoplasm]
(R-HSA-3826589)
0.723
6
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.664
4
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.632
6
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.597
3
UniProt:P61956 SUMO2
6
lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm]
(R-HSA-9761546)
UBE2I-G93-SUMO2 [nucleoplasm]
(R-HSA-3730625)
SUMO2 [nucleoplasm]
(R-HSA-2984281)
lysyl-G93-SUMO2 [cytosol]
(R-HSA-9834803)
UBA2-G93-SUMO2 [nucleoplasm]
(R-HSA-3730618)
SUMO2(1-95) [nucleoplasm]
(R-HSA-2990837)
0.592
4
UniProt:P84243 H3-3A
18
H3F3A [nucleoplasm]
(R-HSA-212295)
Me2K5-H3F3A [nucleoplasm]
(R-HSA-1214206)
Me3K-28-H3F3A [nucleoplasm]
(R-HSA-212282)
Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625747)
p-T12,Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625758)
p-T12, Me2K-10-H3F3A [nucleoplasm]
(R-HSA-5625800)
p-T12,MeK-H3F3A [nucleoplasm]
(R-HSA-5625858)
p-T12-H3F3A [nucleoplasm]
(R-HSA-5625878)
Me2K-10-H3F3A [nucleoplasm]
(R-HSA-427324)
Me3K5-H3F3A [nucleoplasm]
(R-HSA-1214216)
H3F3A [extracellular region]
(R-HSA-977567)
AcK10-H3F3A [nucleoplasm]
(R-HSA-5250654)
Me2K5,Me2aR2-H3F3A [nucleoplasm]
(R-HSA-8936573)
H3R17me2a [nucleoplasm]
(R-HSA-9822613)
MeK28-H3-3A [nucleoplasm]
(R-HSA-9822942)
Me1K5-H3-3A [nucleoplasm]
(R-HSA-9864864)
2xAcK-H3F3A [nucleoplasm]
(R-HSA-427504)
MeK-H3F3A [nucleoplasm]
(R-HSA-427369)
0.591
11
UniProt:Q9NU22 MDN1
0.591
3
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
5
UniProt:O75607 NPM3
0.527
2
UniProt:Q5SY16 NOL9
1
NOL9 [nucleoplasm]
(R-HSA-6791216)
0.527
3
UniProt:P19838 NFKB1
8
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
0.524
2
UniProt:Q92731 ESR2
5
ESR2 [cytosol]
(R-HSA-9020970)
ESR2 [nucleoplasm]
(R-HSA-446165)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
0.462
2
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