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CFTR [plasma membrane]
Stable Identifier
R-HSA-383188
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Cystic fibrosis transmembrane conductance regulator, CFTR_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:O14745
Expand all
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
CFTR transits to the plasma membrane (Homo sapiens)
CFTR [plasma membrane] (Homo sapiens)
CFTR transports Cl- from cytosol to extracellular region (Homo sapiens)
CFTR [plasma membrane] (Homo sapiens)
HCO3- transport through ion channel (Homo sapiens)
CFTR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13569 CFTR
Gene Names
CFTR, ABCC7
Chain
chain:1-1480
Reference Genes
BioGPS Gene:1080 CFTR
COSMIC (genes):CFTR CFTR
CTD Gene:1080 CFTR
dbSNP Gene:1080 CFTR
ENSEMBL:ENSG00000001626 CFTR
HGNC:1884 CFTR
KEGG Gene (Homo sapiens):1080 CFTR
Monarch:1080 CFTR
NCBI Gene:1080 CFTR
OMIM:602421 CFTR
UCSC:P13569 CFTR
Reference Transcript
RefSeq:NM_000492.3 CFTR
Other Identifiers
1080
11722757_at
17050697
205043_at
215702_s_at
3020647
3020648
3020652
3020654
3020658
3020659
3020661
3020662
3020663
3020664
3020666
3020667
3020668
3020670
3020672
3020673
3020674
3020679
3020680
3020682
3020683
3020684
3020685
3020686
3020688
3020689
3020694
3020695
3020696
3020698
3020699
3020701
3020702
3020705
3020706
3020707
3020712
3020719
3020721
3020722
3020723
3020724
3020725
3020726
3020727
36816_s_at
36817_at
3902164
3902300
8135661
A_14_P104877
A_14_P114787
A_14_P129538
A_14_P132049
A_23_P215720
GE62403
GO:0000003
GO:0000166
GO:0003674
GO:0005254
GO:0005260
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0005887
GO:0006464
GO:0006629
GO:0006695
GO:0006810
GO:0006811
GO:0006821
GO:0006904
GO:0006950
GO:0007267
GO:0008150
GO:0009058
GO:0009986
GO:0010008
GO:0015031
GO:0015106
GO:0015108
GO:0015701
GO:0016020
GO:0016021
GO:0016192
GO:0016324
GO:0016579
GO:0016853
GO:0016887
GO:0017081
GO:0019869
GO:0019899
GO:0021700
GO:0022857
GO:0030154
GO:0030165
GO:0030301
GO:0030660
GO:0030665
GO:0031410
GO:0031901
GO:0032991
GO:0034707
GO:0034976
GO:0035377
GO:0035774
GO:0042592
GO:0042626
GO:0043167
GO:0043226
GO:0044281
GO:0045921
GO:0048240
GO:0048856
GO:0050891
GO:0051087
GO:0051454
GO:0055037
GO:0055038
GO:0055085
GO:0060081
GO:0061024
GO:0071320
GO:0106138
GO:1902161
GO:1902476
GO:1902943
GO:1904322
HMNXSV003020096
Hs.663.1.A1_3p_a_at
ILMN_1705813
M55131_at
PH_hs_0024884
TC07000726.hg
g6995995_3p_at
Participates
as a component of
CFTR dimer [plasma membrane] (Homo sapiens)
as a member of
ABCCs [plasma membrane] (Homo sapiens)
as an output of
CFTR transits to the plasma membrane (Homo sapiens)
Other forms of this molecule
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
PolyUb-CFTR [plasma membrane]
CFTR [lysosomal membrane]
CFTR [Golgi-associated vesicle membrane]
CFTR [endosome membrane]
PolyUb-CFTR [endosome membrane]
CFTR F508del [endoplasmic reticulum membrane]
ub-CFTR F508del [cytosol]
ub-CFTR F508del [endoplasmic reticulum membrane]
CFTR G542* [plasma membrane]
CFTR G551D [plasma membrane]
CFTR W1282* [plasma membrane]
CFTR F508del [plasma membrane]
CFTR N1303K [plasma membrane]
CFTR [endoplasmic reticulum membrane]
misfolded CFTR [endoplasmic reticulum membrane]
Inferred To
l(2)03659 [plasma membrane]
(Drosophila melanogaster)
CG17338 [plasma membrane]
(Drosophila melanogaster)
Homologues of CFTR [plasma membrane]
(Caenorhabditis elegans)
Homologues of CFTR [plasma membrane]
(Dictyostelium discoideum)
Homologues of CFTR [plasma membrane]
(Drosophila melanogaster)
cftr [plasma membrane]
(Danio rerio)
rdog [plasma membrane]
(Drosophila melanogaster)
abcC3 [plasma membrane]
(Dictyostelium discoideum)
CFTR [plasma membrane]
(Canis familiaris)
CFTR [plasma membrane]
(Gallus gallus)
CFTR [plasma membrane]
(Sus scrofa)
abcC5 [plasma membrane]
(Dictyostelium discoideum)
abcC10 [plasma membrane]
(Dictyostelium discoideum)
abcC12 [plasma membrane]
(Dictyostelium discoideum)
Dme_CG9270 [plasma membrane]
(Drosophila melanogaster)
abcC8 [plasma membrane]
(Dictyostelium discoideum)
Dmel\CG11898 [plasma membrane]
(Drosophila melanogaster)
Dme_CG7627 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG10505 [plasma membrane]
(Drosophila melanogaster)
mrp-6 [plasma membrane]
(Caenorhabditis elegans)
cft-1 [plasma membrane]
(Caenorhabditis elegans)
Cftr [plasma membrane]
(Drosophila melanogaster)
Cftr [plasma membrane]
(Mus musculus)
Cftr [plasma membrane]
(Rattus norvegicus)
Mrp4 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000483.3
ZINC - World Drugs
CFTR_HUMAN
OpenTargets
ENSG00000001626
ZINC - FDA approved
CFTR_HUMAN
ZINC - Substances
CFTR_HUMAN
ZINC target
P13569
ZINC - Biogenic
CFTR_HUMAN
PRO
P13569
PDB
3ISW
,
6UK1
,
1XMI
,
5TF7
,
5UAK
,
6GJS
,
6HEP
,
6GJU
,
5TFG
,
6MSM
,
5TF8
,
5TFI
,
2BBO
,
4WZ6
,
6GJQ
,
2LOB
,
5TFF
,
5TFD
,
6O1V
,
5D2D
,
5TGK
,
2PZF
,
2PZG
,
6GKD
,
5TFC
,
5TFB
,
5D3F
,
5D3E
,
2PZE
,
6GK4
,
6O2P
,
1XMJ
,
3GD7
,
2BBS
,
5TFA
,
2BBT
,
5TFJ
,
1NBD
IntEnz
5.6.1.6
GeneCards
P13569
HPA
ENSG00000001626-CFTR
Ensembl
ENSP00000497203
,
ENST00000003084
,
ENSP00000003084
,
ENST00000649781
,
ENSG00000001626
Orphanet
15441
ZINC - Predictions - Purchasable
CFTR_HUMAN
HMDB Protein
HMDBP02121
Interactors (65)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14745 NHRF1
0.862
11
UniProt:Q15599 NHRF2
0.829
13
UniProt:P30153 PPP2R1A
2
PPP2R1A [nucleoplasm]
(R-HSA-165968)
PPP2R1A [cytosol]
(R-HSA-165982)
0.76
9
UniProt:P27824 CANX
2
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.758
12
UniProt:P13569 CFTR
17
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.702
12
UniProt:Q5T2W1 NHRF3
0.702
6
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB(1-375) [lysosomal membrane]
(R-HSA-196160)
ACTB(1-375) [nucleoplasm]
(R-HSA-3321990)
ACTB(1-375) [cytosol]
(R-HSA-201861)
ACTB(1-375) [plasma membrane]
(R-HSA-196016)
0.669
5
UniProt:P11021 HSPA5
6
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.643
11
UniProt:Q9HD26 GOPC
3
GOPC [plasma membrane]
(R-HSA-5626572)
GOPC [lysosomal membrane]
(R-HSA-5627281)
GOPC [Golgi-associated vesicle membrane]
(R-HSA-5627067)
0.621
3
UniProt:O15554 KCNN4
1
KCNN4 [plasma membrane]
(R-HSA-977543)
0.602
5
UniProt:P05787 KRT8
1
KRT8 [cytosol]
(R-HSA-446043)
0.589
7
UniProt:Q9HBW0 LPAR2
1
LPAR2 [plasma membrane]
(R-HSA-419393)
0.558
4
UniProt:Q9QX74
1
Shank2 [cytosol]
(R-RNO-6794265)
0.544
2
UniProt:Q9JIL4 NHRF3
0.544
7
UniProt:Q9H8Y8 GORASP2
2
p-T222,T225-GORASP2 [Golgi membrane]
(R-HSA-2422965)
GORASP2 [Golgi membrane]
(R-HSA-2422385)
0.544
3
UniProt:Q99942 RNF5
1
RNF5 [endoplasmic reticulum membrane]
(R-HSA-975990)
0.537
3
UniProt:Q9Y608 LRRF2
0.527
7
UniProt:P31689 DNAJA1
1
DNAJA1 [cytosol]
(R-HSA-3371544)
0.527
10
UniProt:O95425 SVIL
0.527
9
UniProt:O43852 CALU
3
p-CALU [endoplasmic reticulum lumen]
(R-HSA-8956931)
CALU [endoplasmic reticulum lumen]
(R-HSA-350695)
CALU [extracellular region]
(R-HSA-350739)
0.527
2
UniProt:P05783 KRT18
1
KRT18 [cytosol]
(R-HSA-201582)
0.527
9
UniProt:P06753 TPM3
1
TPM3 [cytosol]
(R-HSA-390543)
0.527
11
UniProt:P61619 SEC61A1
2
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
0.527
5
UniProt:P04899 GNAI2
1
GNAI2 [plasma membrane]
(R-HSA-55435)
0.527
8
UniProt:P55060 XPO2
0.527
11
UniProt:P38646 HSPA9
6
HSPA9 [cytosol]
(R-HSA-5251993)
HSPA9 [nucleoplasm]
(R-HSA-5252128)
HSPA9 [mitochondrial matrix]
(R-HSA-8878802)
HSPA9(1-679) [mitochondrial intermembrane space]
(R-HSA-1267968)
HSPA9 [mitochondrial inner membrane]
(R-HSA-1252206)
HSPA9(1-679) [cytosol]
(R-HSA-1267964)
0.527
11
UniProt:Q9NQH7 XPP3
0.527
6
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.527
9
UniProt:P12956 XRCC6
5
XRCC6 [secretory granule lumen]
(R-HSA-6801312)
XRCC6 [nucleoplasm]
(R-HSA-58272)
XRCC6 [extracellular region]
(R-HSA-6806444)
XRCC6 [ficolin-1-rich granule lumen]
(R-HSA-6801300)
XRCC6 [cytosol]
(R-HSA-3134813)
0.527
9
UniProt:P08107 HSP71
0.527
4
UniProt:Q8WWI1 LMO7
1
LMO7 [cytosol]
(R-HSA-8862589)
0.527
9
UniProt:P55072 VCP
8
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [cytosol]
(R-HSA-1181251)
0.527
7
UniProt:Q9UHB6 LIMA1
0.527
9
UniProt:P04080 CSTB
4
CSTB [ficolin-1-rich granule lumen]
(R-HSA-6801376)
CSTB [tertiary granule lumen]
(R-HSA-6801398)
CSTB [extracellular region]
(R-HSA-6801567)
CSTB [secretory granule lumen]
(R-HSA-6801394)
0.527
9
UniProt:P31944 CASP14
2
CASP14(153-242) [cytosol]
(R-HSA-8847687)
CASP14(6-146) [cytosol]
(R-HSA-8847667)
0.527
6
UniProt:P10809 HSPD1
6
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
0.527
10
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.527
11
UniProt:Q9NYL9 TMOD3
1
TMOD3 [cytosol]
(R-HSA-217354)
0.527
10
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
9
UniProt:P31151 S100A7
2
S100A7 [extracellular region]
(R-HSA-5432925)
S100A7 [azurophil granule lumen]
(R-HSA-6799207)
0.527
9
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.527
9
UniProt:P13987 CD59
8
GPI-CD59 [endoplasmic reticulum membrane]
(R-HSA-5689453)
GPI-CD59 [ER to Golgi transport vesicle membrane]
(R-HSA-5689801)
GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689804)
GPI-CD59 [transport vesicle]
(R-HSA-6808775)
GPI-CD59 [Golgi membrane]
(R-HSA-6808772)
CD59 [specific granule membrane]
(R-HSA-6799513)
CD59 [plasma membrane]
(R-HSA-2530458)
CD59 [tertiary granule membrane]
(R-HSA-6800885)
0.527
7
UniProt:P22061 PCMT1
1
PCMT1 [cytosol]
(R-HSA-5676580)
0.527
11
UniProt:O95433 AHSA1
0.527
4
UniProt:P02545 LMNA
3
LMNA-RAF1 fusion [cytosol]
(R-HSA-6802399)
LMNA(1-664) [nucleoplasm]
(R-HSA-535479)
p-LMNA-RAF1 fusion [cytosol]
(R-HSA-6802537)
0.527
11
UniProt:P28799 GRN
2
GRN [extracellular region]
(R-HSA-6806217)
GRN [azurophil granule lumen]
(R-HSA-6799168)
0.527
9
UniProt:O14980 XPO1
2
XPO1 [nucleoplasm]
(R-HSA-165529)
XPO1 [cytosol]
(R-HSA-165539)
0.527
12
UniProt:Q14257 RCN2
0.527
10
UniProt:Q13200 PSMD2
5
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
0.527
9
UniProt:Q14254 FLOT2
1
FLOT2 [plasma membrane]
(R-HSA-8849895)
0.527
9
UniProt:P06702 S100A9
3
S100A9 [secretory granule lumen]
(R-HSA-6804774)
S100A9 [cytosol]
(R-HSA-9626869)
S100A9 [extracellular region]
(R-HSA-5432857)
0.527
9
UniProt:Q15369 ELOC
2
ELOC [cytosol]
(R-HSA-180535)
TCEB1 [nucleoplasm]
(R-HSA-112422)
0.527
5
UniProt:P78527 PRKDC
4
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
0.527
10
UniProt:Q15370 ELOB
2
ELOB [cytosol]
(R-HSA-180551)
TCEB2 [nucleoplasm]
(R-HSA-112423)
0.527
10
UniProt:P35579 MYH9
1
MYH9 [cytosol]
(R-HSA-419173)
0.527
9
UniProt:Q14974 KPNB1
5
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
0.527
10
UniProt:Q9UL46 PSME2
2
PSME2 [cytosol]
(R-HSA-68814)
PSME2 [nucleoplasm]
(R-HSA-174350)
0.527
9
UniProt:O43852-1 CALU
0.524
2
UniProt:Q9BUN8 DERL1
1
DERL1 [endoplasmic reticulum membrane]
(R-HSA-6781898)
0.499
2
UniProt:P51790-2 CLCN3
0.499
2
UniProt:P11274 BCR
4
BCR-FGFR1 fusion [cytosol]
(R-HSA-1604524)
BCR [cytosol]
(R-HSA-195200)
pY177-BCR-p-FGFR1 fusion [cytosol]
(R-HSA-1839041)
BCR-p-FGFR1 fusion [cytosol]
(R-HSA-1838979)
0.491
2
UniProt:P16615-1 ATP2A2
0.471
6
UniProt:Q7LBE3-1 SLC26A9
0.463
2
UniProt:Q5XXA6 ANO1
1
ANO1 [plasma membrane]
(R-HSA-2684927)
0.463
2
UniProt:P51572 BCAP31
6
BCAP31(165-237) [endoplasmic reticulum membrane]
(R-HSA-351909)
BCAP31(2-245) [endoplasmic reticulum membrane]
(R-HSA-201587)
BCAP31(2-164) [endoplasmic reticulum membrane]
(R-HSA-351826)
BCAP31(238-246) [cytosol]
(R-HSA-351912)
BCAP31 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985503)
BCAP31 [endoplasmic reticulum membrane]
(R-HSA-9714333)
0.463
3
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![CFTR [plasma membrane] icon](/icon/R-ICO-012552.svg){kind=icon}
