HCO3- transport through ion channel

Stable Identifier
R-HSA-383190
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Regulation of epithelial chloride flux, which is defective in patients with cystic fibrosis, may be mediated by phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) by cyclic AMP-dependent protein kinase (PKA) or protein kinase C (PKC). CFTR regulates both HCO(3)(-) secretion and HCO(3)(-) salvage in secretory epithelia.

Literature References
PubMed ID Title Journal Year
12403779 The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3

Park, M, Ko, SB, Choi, JY, Muallem, G, Thomas, PJ, Pushkin, A, Lee, MS, Kim, JY, Lee, MG, Muallem, S, Kurtz, I

J Biol Chem 2002
11562789 Na+:HCO(3-) cotransporters (NBC): cloning and characterization

Soleimani, M, Burnham, CE

J Membr Biol 2001
1377674 Phosphorylation of the cystic fibrosis transmembrane conductance regulator

Picciotto, MR, Cohn, JA, Bertuzzi, G, Greengard, P, Nairn, AC

J Biol Chem 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
chloride channel regulator activity of CFTR [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created