RPS6KA1/2/3 phosphorylates CEBPB on S321

Stable Identifier
R-HSA-3857328
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Phosphorylation of CEBPB (C/EBP-beta) serine residue S321 by ERK1/2-activated RSK1, RSK2 or RSK3, downstream of activated RAS, is necessary for the relief of CEBPB autoinhibiton (Lee et al. 2010). Phosphorylation on other sites may also be involved in CEBPB activation.
Literature References
PubMed ID Title Journal Year
20351173 RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity

Shuman, JD, Cohen, MS, Sakchaisri, K, Taunton, J, Lee, S, Sebastian, T, Smart, RC, Veenstra, TD, Xiao, Z, Yu, LR, Miller, M, Copeland, TD, Guszczynski, T, Johnson, PF

Mol. Cell. Biol. 2010
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of Phospho-Ribosomal protein S6 kinase [nucleoplasm]

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