RPS6KA1/2/3 phosphorylates CEBPB on S321

Stable Identifier
R-HSA-3857328
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of CEBPB (C/EBP-beta) serine residue S321 by ERK1/2-activated RSK1, RSK2 or RSK3, downstream of activated RAS, is necessary for the relief of CEBPB autoinhibiton (Lee et al. 2010). Phosphorylation on other sites may also be involved in CEBPB activation.

Literature References
PubMed ID Title Journal Year
20351173 RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity

Lee, S, Shuman, JD, Guszczynski, T, Sakchaisri, K, Sebastian, T, Copeland, TD, Miller, M, Cohen, MS, Taunton, J, Smart, RC, Xiao, Z, Yu, LR, Veenstra, TD, Johnson, PF

Mol. Cell. Biol. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Phospho-Ribosomal protein S6 kinase [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created