MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB

Stable Identifier
R-HSA-3857329
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of CEBPB (C/EBP-beta) transcription factor on threonine residue T235 happens downstream of activated RAS, is mediated by MAPKs - likely MAPK3 (ERK1) and MAPK1 (ERK2), and positively affects CEBPB-mediated transcription of IL6 (Nakajima et al. 1993).

Literature References
PubMed ID Title Journal Year
8384717 Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6

Nakajima, T, Kinoshita, S, Sasagawa, T, Sasaki, K, Naruto, M, Kishimoto, T, Akira, S

Proc. Natl. Acad. Sci. U.S.A. 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created