Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-T235-CEBPB [nucleoplasm]
Stable Identifier
R-HSA-3857343
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Homo sapiens)
p-T235-CEBPB [nucleoplasm] (Homo sapiens)
RPS6KA1/2/3 phosphorylates CEBPB on S321 (Homo sapiens)
p-T235-CEBPB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17676 CEBPB
Gene Names
CEBPB, TCF5, PP9092
Chain
chain:1-345
Reference Genes
BioGPS Gene:1051 CEBPB
COSMIC (genes):CEBPB CEBPB
CTD Gene:1051 CEBPB
dbSNP Gene:1051 CEBPB
ENSEMBL:ENSG00000172216 CEBPB
ENSEMBL_homo_sapiens_GENE:ENSG00000172216.6 CEBPB
HGNC:1834 CEBPB
KEGG Gene (Homo sapiens):1051 CEBPB
Monarch:1051 CEBPB
NCBI Gene:1051 CEBPB
OMIM:189965 CEBPB
UCSC:P17676 CEBPB
Reference Transcript
RefSeq:NM_001285878.1 CEBPB
RefSeq:NM_001285879.1 CEBPB
RefSeq:NM_005194.3 CEBPB
Other Identifiers
1051
11743077_s_at
16914812
212501_PM_at
212501_at
38354_at
3888614
3888615
3888616
3888617
3888618
3888619
3888620
3888621
3888622
3888623
43806_at
8063386
A_14_P109564
A_14_P113115
A_14_P134847
A_23_P143242
A_23_P411296
GE59775
GE85855
GO:0000122
GO:0000779
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000979
GO:0000981
GO:0001227
GO:0001228
GO:0001541
GO:0001892
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006953
GO:0006954
GO:0006955
GO:0007155
GO:0012501
GO:0016363
GO:0019900
GO:0022414
GO:0023052
GO:0030154
GO:0030182
GO:0031490
GO:0032496
GO:0032675
GO:0032753
GO:0033598
GO:0034976
GO:0035035
GO:0036488
GO:0042130
GO:0042742
GO:0042802
GO:0042803
GO:0042826
GO:0043226
GO:0043524
GO:0043565
GO:0044389
GO:0045444
GO:0045595
GO:0045600
GO:0045669
GO:0045670
GO:0045892
GO:0045893
GO:0045944
GO:0048856
GO:0050729
GO:0050873
GO:0060644
GO:0061515
GO:0070059
GO:0070169
GO:0071230
GO:0072574
GO:0090575
GO:0097421
GO:0098542
GO:0120162
GO:0140110
GO:0140467
GO:1901329
GO:1990647
GO:1990837
GO:2000120
GO:2001198
HMNXSV003050518
Hs.99029.0.S2_3p_at
ILMN_1693014
PH_hs_0005496
TC20000399.hg
TC20001277.hg
Participates
as an output of
MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Homo sapiens)
as an input of
RPS6KA1/2/3 phosphorylates CEBPB on S321 (Homo sapiens)
Other forms of this molecule
p-T235, S321-CEBPB [nucleoplasm]
CEBPB [nucleoplasm]
Inferred To
phospho-Cebpb [nucleoplasm]
(Mus musculus)
phospho-Cebpb [nucleoplasm]
(Rattus norvegicus)
Homologues of p-T235-CEBPB [nucleoplasm]
(Drosophila melanogaster)
phospho-CEBPB [nucleoplasm]
(Bos taurus)
phospho-CEBPB [nucleoplasm]
(Canis familiaris)
phospho-CEBPB [nucleoplasm]
(Gallus gallus)
phospho-CEBPB [nucleoplasm]
(Sus scrofa)
phospho-cebpb [nucleoplasm]
(Danio rerio)
phospho-slbo [nucleoplasm]
(Drosophila melanogaster)
phospho-Mabi [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-threonine at 235
Coordinate
235
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001272808.1
,
NP_005185.2
,
NP_001272807.1
OpenTargets
ENSG00000172216
GeneCards
P17676
HPA
ENSG00000172216-CEBPB
Ensembl
ENSP00000305422
,
ENSG00000172216
,
ENST00000303004
PRO
P17676
Pharos - Targets
P17676
PDB
1H88
,
6MG2
,
1H89
,
1H8A
,
8K8D
,
6MG1
,
7L4V
,
1IO4
,
1GU4
,
2E43
,
1HJB
,
6MG3
,
7UPZ
,
1GU5
,
2E42
,
1GTW
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.609
2
UniProt:P06422 VE2
0.602
4
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.59
2
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.59
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.556
4
UniProt:P06790 VE2
0.544
4
UniProt:P03120 VE2
0.544
2
UniProt:P03122 VE2
0.544
3
UniProt:P17096 HMGA1
2
HMGA1 [cytosol]
(R-HSA-3004619)
HMGA1 [nucleoplasm]
(R-HSA-3004623)
0.544
3
UniProt:Q86X55 CARM1
1
CARM1 [nucleoplasm]
(R-HSA-400139)
0.524
2
IntAct:EBI-9996975 MMP1
0.499
2
UniProt:P15941-PRO_0000317447 MUC1
0.463
8
IntAct:EBI-9981598 3BHS2
0.462
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text