Reactome | p-T235-CEBPB [nucleoplasm]

p-T235-CEBPB [nucleoplasm]

Stable Identifier

R-HSA-3857343

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser for interactor UniProt:Q86X55 CARM1

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External Reference Information

External Reference

UniProt:P17676 CEBPB

Gene Names

CEBPB, TCF5, PP9092

Chain

chain:1-345

Reference Genes

BioGPS Gene:1051 CEBPB

COSMIC (genes):CEBPB CEBPB

CTD Gene:1051 CEBPB

dbSNP Gene:1051 CEBPB

ENSEMBL:ENSG00000172216 CEBPB

HGNC:1834 CEBPB

KEGG:hsa:1051 CEBPB

Monarch:1051 CEBPB

NCBI Gene:1051 CEBPB

OMIM:189965 CEBPB

UCSC:P17676 CEBPB

Reference Transcript

Participates

as an output of

MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Homo sapiens)

as an input of

RPS6KA1/2/3 phosphorylates CEBPB on S321 (Homo sapiens)

Other forms of this molecule

p-T235, S321-CEBPB [nucleoplasm]

CEBPB [nucleoplasm]

Inferred To

phospho-Cebpb [nucleoplasm] (Mus musculus)

phospho-Cebpb [nucleoplasm] (Rattus norvegicus)

Homologues of p-T235-CEBPB [nucleoplasm] (Drosophila melanogaster)

phospho-CEBPB [nucleoplasm] (Bos taurus)

phospho-CEBPB [nucleoplasm] (Canis familiaris)

phospho-CEBPB [nucleoplasm] (Gallus gallus)

phospho-CEBPB [nucleoplasm] (Sus scrofa)

phospho-cebpb [nucleoplasm] (Danio rerio)

phospho-slbo [nucleoplasm] (Drosophila melanogaster)

phospho-Mabi [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-threonine at 235

Coordinate

235

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_005185.2, NP_001272807.1, NP_001272808.1

OpenTargets

ENSG00000172216

ENSEMBL

ENSP00000305422, ENST00000303004, ENSG00000172216

HPA

ENSG00000172216-CEBPB

GeneCards

CEBPB

PRO

P17676

Pharos - Targets

P17676

GlyGen

P17676

PDB

1H8A, 7UPZ, 6MG2, 6MG3, 6MG1, 1HJB, 2E43, 1GU4, 1GU5, 2E42, 1H88, 8K8D, 1H89, 1GTW, 1IO4, 7L4V

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.609	2
UniProt:P06422 VE2			0.602	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.59	2
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.59	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.556	4
UniProt:P17096 HMGA1	2	HMGA1 [nucleoplasm] (R-HSA-3004623) HMGA1 [cytosol] (R-HSA-3004619)	0.544	3
UniProt:P03122 VE2			0.544	3
UniProt:P03120 VE2			0.544	2
UniProt:P06790 VE2			0.544	4
UniProt:Q86X55 CARM1	1	CARM1 [nucleoplasm] (R-HSA-400139)	0.524	2
IntAct:EBI-9996975 MMP1			0.499	2
UniProt:P15941-PRO_0000317447 MUC1			0.463	8
IntAct:EBI-9981598 3BHS2			0.462	3

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