Reactome | HSPA5 [endoplasmic reticulum lumen]

HSPA5 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-387190

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

78 kDa glucose-regulated protein, BiP, GRP78

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External Reference Information

External Reference

UniProt:P11021 HSPA5

Gene Names

HSPA5, GRP78

Chain

signal peptide:1-18, chain:19-654

Reference Genes

BioGPS Gene:3309 HSPA5

COSMIC (genes):HSPA5 HSPA5

CTD Gene:3309 HSPA5

dbSNP Gene:3309 HSPA5

ENSEMBL:ENSG00000044574 HSPA5

HGNC:5238 HSPA5

KEGG Gene (Homo sapiens):3309 HSPA5

Monarch:3309 HSPA5

NCBI Gene:3309 HSPA5

OMIM:138120 HSPA5

Reference Transcript

RefSeq:NM_005347.4 HSPA5

Other Identifiers

0003710288

11725930_s_at

11725931_at

11725932_a_at

11725933_at

11725934_x_at

11758169_s_at

17098411

211936_at

230031_at

2331066

2331070

2331074

2331076

2331077

2750337

2750344

2750345

2750346

3225399

3225400

3225401

3225402

3225403

3225404

3225406

3225407

3225408

3225410

3225411

3225413

3225416

3225417

3225418

3225419

3225420

3309

36614_at

47634_at

8164165

A_24_P18190

A_24_P98411

GE86936

GO:0000003

GO:0000166

GO:0001554

GO:0003674

GO:0005509

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005783

GO:0005788

GO:0005789

GO:0005790

GO:0005793

GO:0005829

GO:0005886

GO:0005925

GO:0006457

GO:0006464

GO:0006605

GO:0006810

GO:0006950

GO:0006983

GO:0007165

GO:0008150

GO:0008180

GO:0008219

GO:0009056

GO:0009058

GO:0009314

GO:0009986

GO:0010976

GO:0015031

GO:0016020

GO:0016787

GO:0016887

GO:0019899

GO:0019904

GO:0021589

GO:0021680

GO:0021762

GO:0022607

GO:0030154

GO:0030176

GO:0030182

GO:0030335

GO:0030433

GO:0030496

GO:0030512

GO:0030968

GO:0031072

GO:0031204

GO:0031333

GO:0031398

GO:0031410

GO:0031625

GO:0032991

GO:0034620

GO:0034641

GO:0034663

GO:0034975

GO:0034976

GO:0035437

GO:0035690

GO:0036498

GO:0036499

GO:0036500

GO:0040011

GO:0042026

GO:0042149

GO:0042220

GO:0042470

GO:0043022

GO:0043066

GO:0043167

GO:0043226

GO:0043231

GO:0044183

GO:0045296

GO:0048856

GO:0048870

GO:0051082

GO:0051085

GO:0051087

GO:0051402

GO:0051603

GO:0051787

GO:0055085

GO:0060904

GO:0065003

GO:0070062

GO:0071236

GO:0071277

GO:0071287

GO:0071320

GO:0071353

GO:0071480

GO:0097501

GO:1901998

GO:1903891

GO:1903894

GO:1903895

GO:1903897

GO:1904313

GO:1990090

GO:1990440

HMNXSV003037349

Hs.75410.1.S1_3p_at

Hs.75410.4.A1_3p_at

ILMN_1773865

M19645_at

PH_hs_0023711

TC09001589.hg

Participates

as a component of

BiP:Unfolded Protein [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

HSPA5 [extracellular region]

HSPA5 [endoplasmic reticulum membrane]

HSPA5 [cytosol]

HSPA5 [nucleoplasm]

HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane]

Cross References

RefSeq

NP_005338.1

OpenTargets

ENSG00000044574

ZINC - Substances

GRP78_HUMAN

ZINC target

P11021

ZINC - Biogenic

GRP78_HUMAN

PRO

P11021

GlyGen

P11021

PDB

5EVZ, 5E84, 5EX5, 5F0X, 3LDL, 6DFM, 3LDN, 6ASY, 3LDO, 5E86, 6CZ1, 5EXW, 5F2R, 5F1X, 3IUC, 5E85, 6DFO, 3LDP, 6DWS, 6DO2, 5EY4

ZINC - Metabolites

GRP78_HUMAN

IntEnz

3.6.4.10

HPA

ENSG00000044574-HSPA5

GeneCards

P11021

Ensembl

ENST00000324460, ENSG00000044574, ENSP00000324173

Pharos - Targets

P11021

ZINC - Predictions - Purchasable

GRP78_HUMAN

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.779	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.742	5
ChEBI:132781 HA15			0.687	8
UniProt:Q9H173 SIL1			0.669	9
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.659	4
UniProt:P0DTC2 S	16	high-mannose N-glycan-PALM-Spike [endoplasmic reticulum lumen] (R-COV-9696917) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) fully glycosylated Spike [virion membrane] (R-COV-9698327) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880)	0.644	6
UniProt:P13569 CFTR	17	CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR [plasma membrane] (R-HSA-383188) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR [endosome membrane] (R-HSA-6782965) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) CFTR N1303K [plasma membrane] (R-HSA-5678983) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) ub-CFTR F508del [cytosol] (R-HSA-8866838) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.643	11
UniProt:O75460-1 ERN1			0.612	4
UniProt:Q9BYF1 ACE2	5	ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480) ACE2(18-805) [plasma membrane] (R-HSA-2022344)	0.61	4
UniProt:Q6E0U4 DMKN			0.602	3
UniProt:Q9NZJ5 EIF2AK3	3	EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713456) EIF2AK3(30-144)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9713454) EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046)	0.589	4
UniProt:Q96IZ0 PAWR			0.581	8
UniProt:Q62627 PAWR			0.576	4
UniProt:P04049 RAF1	20	p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) RAF1 [cytosol] (R-HSA-167205) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115)	0.576	5
UniProt:Q15084 PDIA6	3	p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530) PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049)	0.564	2
UniProt:P14625 HSP90B1	4	HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.564	2
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.564	2
UniProt:P61619 SEC61A1	2	SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813) SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591)	0.558	3
UniProt:Q6PF05 TT23L			0.556	3
UniProt:Q9UHI5 SLC7A8	1	SLC7A8 [plasma membrane] (R-HSA-352156)	0.556	3
UniProt:Q13404 UBE2V1	1	UBE2V1 [cytosol] (R-HSA-205753)	0.556	3
UniProt:Q15486 GUSP1			0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:P05067 APP	20	APP(672-711) [extracellular region] (R-HSA-976740) APP-C99 [cytosol] (R-HSA-9617603) APP(672-711) [cytosol] (R-HSA-877188) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(688-770) [plasma membrane] (R-HSA-9010028) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-687) [extracellular region] (R-HSA-9010033) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P04626 ERBB2	20	p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) ERBB2 G309E [plasma membrane] (R-HSA-9665342) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) ERBB2 G309A [plasma membrane] (R-HSA-9665349)	0.547	2
UniProt:Q91YW3	4	Dnajc3 [endoplasmic reticulum lumen] (R-MMU-448201) Dnajc3 [extracellular region] (R-MMU-6806239) phospho-Dnajc3 [endoplasmic reticulum lumen] (R-MMU-8956975) Dnajc3 [azurophil granule lumen] (R-MMU-6799146)	0.544	2
UniProt:Q77M19 Q77M19			0.527	2
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:Q92905 COPS5	2	COPS5 [cytosol] (R-HSA-416963) COPS5 [nucleoplasm] (R-HSA-5697019)	0.527	2
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.527	2
UniProt:O94905 ERLIN2	3	ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520) ERLIN2(1-185):FGFR1(c.-88-822) fusion [plasma membrane] (R-HSA-8853148) ERLIN2(1-185):p-8Y FGFR1(c.-88-822) fusion [plasma membrane] (R-HSA-8853122)	0.527	2
UniProt:P00533 EGFR	20	p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211)	0.527	5
UniProt:P15056 BRAF	20	BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF E501G [cytosol] (R-HSA-9651132) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) BRAF D594N [cytosol] (R-HSA-6802299) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L505H [cytosol] (R-HSA-9648845) BRAF D594G [cytosol] (R-HSA-6802295) BRAF E586K [cytosol] (R-HSA-6802308) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF N581D [cytosol] (R-HSA-9651152) BRAF G464E [cytosol] (R-HSA-6802369) BRAF L597V [cytosol] (R-HSA-6802397) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469V [cytosol] (R-HSA-9648620) BRAF D638E [cytosol] (R-HSA-9651125) BRAF A246P [cytosol] (R-HSA-9651123) BRAF V600K [cytosol] (R-HSA-6802502) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305)	0.527	3
UniProt:Q6T424 Q6T424			0.525	3
UniProt:K0BRG7 K0BRG7			0.524	9
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.508	3
UniProt:P08670 VIM	11	VIM(430-466) [cytosol] (R-HSA-350316) VIM(260-466) [cytosol] (R-HSA-350314) VIM [cytosol] (R-HSA-201600) Vimentin [microtubule organizing center] (R-HSA-9657898) VIM(2-85) [cytosol] (R-HSA-350264) VIM(2-429) [cytosol] (R-HSA-350317) VIM(2-259) [cytosol] (R-HSA-350323) Vimentin [lysosomal lumen] (R-HSA-9659977) VIM(86-466) [cytosol] (R-HSA-350294) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [cytosol] (R-HSA-9646687)	0.508	3
UniProt:P02452 COL1A1	20	3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315)	0.499	2
UniProt:P36780 VE2			0.488	2
UniProt:Q5NES6 Q5NES6			0.488	2
UniProt:P31749 AKT1	13	AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252)	0.471	2
UniProt:Q8N0X7 SPART			0.462	2
UniProt:Q00005 2ABB			0.462	2

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