Reactome | HSPA5 [endoplasmic reticulum lumen]

HSPA5 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-387190

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

78 kDa glucose-regulated protein, BiP, GRP78

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External Reference Information

External Reference

UniProt:P11021 HSPA5

Gene Names

HSPA5, GRP78

Chain

signal peptide:1-18, chain:19-654

Reference Genes

BioGPS Gene:3309 HSPA5

COSMIC (genes):HSPA5 HSPA5

CTD Gene:3309 HSPA5

dbSNP Gene:3309 HSPA5

ENSEMBL:ENSG00000044574 HSPA5

HGNC:5238 HSPA5

KEGG Gene (Homo sapiens):3309 HSPA5

Monarch:3309 HSPA5

NCBI Gene:3309 HSPA5

OMIM:138120 HSPA5

Reference Transcript

RefSeq:NM_005347.4 HSPA5

Other Identifiers

0003710288

11725930_s_at

11725931_at

11725932_a_at

11725933_at

11725934_x_at

11758169_s_at

17098411

211936_at

230031_at

2331066

2331070

2331074

2331076

2331077

2750337

2750344

2750345

2750346

3225399

3225400

3225401

3225402

3225403

3225404

3225406

3225407

3225408

3225410

3225411

3225413

3225416

3225417

3225418

3225419

3225420

3309

36614_at

38845

38846

3IUC

3LDL

3LDN

3LDO

3LDP

47634_at

5221

5E84

5E85

5E86

5EVZ

5EX5

5EXW

5EY4

5F0X

5F1X

5F2R

6ASY

6CZ1

8164165

A_24_P18190

A_24_P98411

AAA52614

AAF13605

AAF42836

AAH20235

ABD04090

ACJ13671

AF188611

AF216292

AJ271729

AL354710

BC020235

CAA42595

CAA61201

CAB005221

CAB71335

CCDS6863

CH471090

DQ385847

EAW87620

ENSG00000044574

ENSP00000324173

ENST00000324460

ENST00000324460.6

EntrezGene:3309

EntrezGene:HSPA5

EU794617

GE86936

GO:0000003

GO:0000166

GO:0001554

GO:0003674

GO:0005509

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005783

GO:0005788

GO:0005789

GO:0005790

GO:0005793

GO:0005829

GO:0005886

GO:0005925

GO:0006457

GO:0006464

GO:0006605

GO:0006810

GO:0006950

GO:0006983

GO:0006986

GO:0007165

GO:0008150

GO:0008180

GO:0008219

GO:0009056

GO:0009058

GO:0009314

GO:0009986

GO:0010976

GO:0015031

GO:0016020

GO:0016787

GO:0016887

GO:0019899

GO:0019904

GO:0021589

GO:0021680

GO:0021762

GO:0030154

GO:0030176

GO:0030182

GO:0030335

GO:0030433

GO:0030496

GO:0030512

GO:0030968

GO:0031072

GO:0031204

GO:0031398

GO:0031410

GO:0031625

GO:0032991

GO:0034605

GO:0034620

GO:0034641

GO:0034663

GO:0034975

GO:0034976

GO:0035437

GO:0035690

GO:0036498

GO:0036499

GO:0036500

GO:0040011

GO:0042026

GO:0042149

GO:0042220

GO:0042470

GO:0042623

GO:0043022

GO:0043066

GO:0043167

GO:0043226

GO:0043231

GO:0044183

GO:0045296

GO:0048856

GO:0048870

GO:0051082

GO:0051085

GO:0051087

GO:0051402

GO:0051603

GO:0051787

GO:0055085

GO:0060904

GO:0070062

GO:0071236

GO:0071277

GO:0071287

GO:0071320

GO:0071353

GO:0071480

GO:0090074

GO:0097501

GO:1901998

GO:1903891

GO:1903894

GO:1903895

GO:1903897

GO:1904313

GO:1990090

GO:1990440

HEL-S-89n

HGNC:5238

HPA038845

HPA038846

Hs.75410.1.S1_3p_at

Hs.75410.4.A1_3p_at

HSPA5

HSPA5-201

ILMN_1773865

IPR013126

IPR018181

IPR029047

IPR029048

IPR042050

M19645

M19645_at

MIM:138120

NM_005347

NP_005338

PF00012

PH_hs_0023711

PR00301

TC09001589.hg

UPI0000001061

V9HWB4

X59969

X87949

Participant Of

hasComponent

BiP:Unfolded Protein [endoplasmic reticulum lumen]

Other forms of this molecule

HSPA5 [extracellular region]

HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane]

HSPA5 [endoplasmic reticulum membrane]

HSPA5 [nucleoplasm]

HSPA5 [cytosol]

Cross References

RefSeq

NP_005338.1

ZINC - Metabolites

GRP78_HUMAN

OpenTargets

ENSG00000044574

IntEnz

3.6.4.10

ZINC - Substances

GRP78_HUMAN

GeneCards

P11021

ZINC - Biogenic

GRP78_HUMAN

ZINC target

P11021

PRO

P11021

ZINC - Predictions - Purchasable

GRP78_HUMAN

PDB

5E85, 6DFO, 6DWS, 5F1X, 5EY4, 3LDO, 6DO2, 5EX5, 6DFM, 3LDN, 5E84, 6CZ1, 5EXW, 5F2R, 3IUC, 3LDL, 5F0X, 5EVZ, 6ASY, 3LDP, 5E86

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.779	4
ChEBI:132781 HA15			0.691	8
UniProt:O75460-1 ERN1			0.612	4
UniProt:Q6E0U4 DMKN			0.602	3
UniProt:Q9NZJ5 EIF2AK3	1	EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046)	0.589	4
UniProt:Q96IZ0 PAWR			0.581	8
UniProt:Q62627 PAWR			0.576	4
UniProt:P04049 RAF1	10	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [plasma membrane] (R-HSA-206222) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.576	5
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.564	2
UniProt:P14625 HSP90B1	4	HSP90B1 [extracellular region] (R-HSA-3221653) HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.564	2
UniProt:Q15084 PDIA6	3	p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530) PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049)	0.564	2
UniProt:P61619 SEC61A1	2	SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813) SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591)	0.558	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2
UniProt:Q91YW3	4	DNAJC3 [azurophil granule lumen] (R-MMU-6799146) DNAJC3 [extracellular region] (R-MMU-6806239) phospho-p-DNAJC3 [endoplasmic reticulum lumen] (R-MMU-8956975) DNAJC3 [endoplasmic reticulum lumen] (R-MMU-448201)	0.544	2
UniProt:Q77M19 Q77M19			0.527	2
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.527	2
UniProt:O94905 ERLIN2	3	ERLIN2(1-185):FGFR1(c.-88-822) fusion [plasma membrane] (R-HSA-8853148) ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520) ERLIN2(1-185):p-8Y FGFR1(c.-88-822) fusion [plasma membrane] (R-HSA-8853122)	0.527	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.527	5
UniProt:Q6T424 Q6T424			0.525	3
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.524	2
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.508	3
UniProt:P08670 VIM	11	VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323)	0.508	3
UniProt:P36780 VE2			0.488	2
UniProt:Q8N0X7 SPART			0.462	2
UniProt:Q00005 2ABB			0.462	2