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HSPA5 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-387190
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
78 kDa glucose-regulated protein, BiP, GRP78
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)
BiP:Unfolded Protein [endoplasmic reticulum lumen] (Homo sapiens)
HSPA5 [endoplasmic reticulum lumen] (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)
BiP:Unfolded Protein [endoplasmic reticulum lumen] (Homo sapiens)
HSPA5 [endoplasmic reticulum lumen] (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
Dissociation of PERK:BiP Heterodimer (Homo sapiens)
BiP:Unfolded Protein [endoplasmic reticulum lumen] (Homo sapiens)
HSPA5 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11021 HSPA5
Gene Names
HSPA5, GRP78
Chain
signal peptide:1-18, chain:19-654
Reference Genes
BioGPS Gene:3309 HSPA5
COSMIC (genes):HSPA5 HSPA5
CTD Gene:3309 HSPA5
dbSNP Gene:3309 HSPA5
ENSEMBL:ENSG00000044574 HSPA5
HGNC:5238 HSPA5
KEGG Gene (Homo sapiens):3309 HSPA5
Monarch:3309 HSPA5
NCBI Gene:3309 HSPA5
OMIM:138120 HSPA5
Reference Transcript
RefSeq:NM_005347.4 HSPA5
Other Identifiers
0003710288
11725930_s_at
11725931_at
11725932_a_at
11725933_at
11725934_x_at
11758169_s_at
17098411
211936_at
230031_at
2331066
2331070
2331074
2331076
2331077
2750337
2750344
2750345
2750346
3225399
3225400
3225401
3225402
3225403
3225404
3225406
3225407
3225408
3225410
3225411
3225413
3225416
3225417
3225418
3225419
3225420
3309
36614_at
38845
38846
3IUC
3LDL
3LDN
3LDO
3LDP
47634_at
5221
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
8164165
A_24_P18190
A_24_P98411
AAA52614
AAF13605
AAF42836
AAH20235
ABD04090
ACJ13671
AF188611
AF216292
AJ271729
AL354710
BC020235
CAA42595
CAA61201
CAB005221
CAB71335
CCDS6863
CH471090
DQ385847
EAW87620
ENSG00000044574
ENSP00000324173
ENST00000324460
ENST00000324460.6
EntrezGene:3309
EntrezGene:HSPA5
EU794617
GE86936
GO:0000003
GO:0000166
GO:0001554
GO:0003674
GO:0005509
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005739
GO:0005783
GO:0005788
GO:0005789
GO:0005790
GO:0005793
GO:0005829
GO:0005886
GO:0005925
GO:0006457
GO:0006464
GO:0006605
GO:0006810
GO:0006950
GO:0006983
GO:0006986
GO:0007165
GO:0008150
GO:0008180
GO:0008219
GO:0009056
GO:0009058
GO:0009314
GO:0009986
GO:0010976
GO:0015031
GO:0016020
GO:0016787
GO:0016887
GO:0019899
GO:0019904
GO:0021589
GO:0021680
GO:0021762
GO:0022607
GO:0030154
GO:0030176
GO:0030182
GO:0030335
GO:0030433
GO:0030496
GO:0030512
GO:0030968
GO:0031072
GO:0031204
GO:0031333
GO:0031398
GO:0031410
GO:0031625
GO:0032991
GO:0034605
GO:0034620
GO:0034641
GO:0034663
GO:0034975
GO:0034976
GO:0035437
GO:0035690
GO:0036498
GO:0036499
GO:0036500
GO:0040011
GO:0042026
GO:0042149
GO:0042220
GO:0042470
GO:0042623
GO:0043022
GO:0043066
GO:0043167
GO:0043226
GO:0043231
GO:0044183
GO:0045296
GO:0048856
GO:0048870
GO:0051082
GO:0051085
GO:0051087
GO:0051402
GO:0051603
GO:0051787
GO:0055085
GO:0060904
GO:0065003
GO:0070062
GO:0071236
GO:0071277
GO:0071287
GO:0071320
GO:0071353
GO:0071480
GO:0090074
GO:0097501
GO:1901998
GO:1903891
GO:1903894
GO:1903895
GO:1903897
GO:1904313
GO:1990090
GO:1990440
HEL-S-89n
HGNC:5238
HPA038845
HPA038846
Hs.75410.1.S1_3p_at
Hs.75410.4.A1_3p_at
HSPA5
HSPA5-201
ILMN_1773865
IPR013126
IPR018181
IPR029047
IPR029048
IPR042050
M19645
M19645_at
MIM:138120
NM_005347
NP_005338
PF00012
PH_hs_0023711
PR00301
TC09001589.hg
UPI0000001061
V9HWB4
X59969
X87949
Participant Of
hasComponent
BiP:Unfolded Protein [endoplasmic reticulum lumen]
Other forms of this molecule
HSPA5 [extracellular region]
HSPA5 [cytosol]
HSPA5 [nucleoplasm]
HSPA5 [endoplasmic reticulum membrane]
HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane]
Cross References
RefSeq
NP_005338.1
OpenTargets
ENSG00000044574
ZINC - Substances
GRP78_HUMAN
ZINC target
P11021
ZINC - Biogenic
GRP78_HUMAN
PRO
P11021
PDB
3LDN
,
6DFM
,
5EXW
,
6ASY
,
5F2R
,
3LDP
,
5EY4
,
5E86
,
5E84
,
5F0X
,
3IUC
,
5EX5
,
5EVZ
,
6DWS
,
6DO2
,
3LDL
,
5E85
,
3LDO
,
5F1X
,
6DFO
,
6CZ1
ZINC - Metabolites
GRP78_HUMAN
IntEnz
3.6.4.10
GeneCards
P11021
HPA
ENSG00000044574-HSPA5
Ensembl
ENSP00000324173
,
ENST00000324460
,
ENSG00000044574
ZINC - Predictions - Purchasable
GRP78_HUMAN
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UBS4 DNAJB11
1
DNAJB11 [endoplasmic reticulum lumen]
(R-HSA-381040)
0.779
4
ChEBI:132781 HA15
0.691
8
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.659
4
UniProt:O75460-1 ERN1
0.612
4
UniProt:Q6E0U4 DMKN
0.602
3
UniProt:Q9NZJ5 EIF2AK3
1
EIF2AK3 [endoplasmic reticulum membrane]
(R-HSA-381046)
0.589
4
UniProt:Q96IZ0 PAWR
0.581
8
UniProt:Q62627 PAWR
0.576
4
UniProt:P04049 RAF1
10
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.576
5
UniProt:Q15084 PDIA6
3
p-PDIA6 [endoplasmic reticulum lumen]
(R-HSA-8957031)
PDIA6 [endoplasmic reticulum membrane]
(R-HSA-535530)
PDIA6 [endoplasmic reticulum lumen]
(R-HSA-3009049)
0.564
2
UniProt:P14625 HSP90B1
4
HSP90B1 [extracellular region]
(R-HSA-3221653)
HSP90B1 [endocytic vesicle lumen]
(R-HSA-3221623)
p-HSP90B1 [endoplasmic reticulum lumen]
(R-HSA-8957016)
HSP90B1 [endoplasmic reticulum lumen]
(R-HSA-981545)
0.564
2
UniProt:Q9Y4L1 HYOU1
3
HYOU1 [extracellular region]
(R-HSA-3221939)
HYOU1 [endocytic vesicle lumen]
(R-HSA-3221924)
HYOU1 [endoplasmic reticulum lumen]
(R-HSA-535542)
0.564
2
UniProt:P61619 SEC61A1
2
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
0.558
3
UniProt:P04626 ERBB2
117
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665656)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
p-Y-ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 L755W [plasma membrane]
(R-HSA-9654193)
p-Y-ERBB2 T733I [plasma membrane]
(R-HSA-9654610)
p-Y-ERBB2 H878R [plasma membrane]
(R-HSA-9654835)
p-Y-ERBB2 L869R [plasma membrane]
(R-HSA-9654730)
p-Y-ERBB2 G776S [plasma membrane]
(R-HSA-9664608)
p-Y-ERBB2 L869Q [plasma membrane]
(R-HSA-9654732)
p-Y-ERBB2 G776L [plasma membrane]
(R-HSA-9664600)
p-Y-ERBB2 G776V [plasma membrane]
(R-HSA-9664602)
p-Y-ERBB2 G776C [plasma membrane]
(R-HSA-9664611)
ERBB2 D769Y [plasma membrane]
(R-HSA-9646620)
ERBB2 L755P [plasma membrane]
(R-HSA-9646494)
ERBB2 V842I [plasma membrane]
(R-HSA-9646703)
ERBB2 H878Y [plasma membrane]
(R-HSA-9646824)
ERBB2 T798M [plasma membrane]
(R-HSA-9646825)
ERBB2 D769H [plasma membrane]
(R-HSA-9646617)
ERBB2 T862A [plasma membrane]
(R-HSA-9649434)
ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665621)
ERBB2 L755S [plasma membrane]
(R-HSA-9646423)
ERBB2 I767M [plasma membrane]
(R-HSA-9646737)
ERBB2 V777L [plasma membrane]
(R-HSA-9646579)
ERBB2 D769N [plasma membrane]
(R-HSA-9646636)
ERBB2 T733I [plasma membrane]
(R-HSA-9646765)
ERBB2 V777M [plasma membrane]
(R-HSA-9646591)
ERBB2 V777E [plasma membrane]
(R-HSA-9646586)
ERBB2 L755W [plasma membrane]
(R-HSA-9646516)
ERBB2 L755M [plasma membrane]
(R-HSA-9646517)
ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665622)
ERBB2 H878R [plasma membrane]
(R-HSA-9646822)
ERBB2 V842E [plasma membrane]
(R-HSA-9646710)
ERBB2 T798I [plasma membrane]
(R-HSA-9646823)
ERBB2 R896C [plasma membrane]
(R-HSA-9646714)
ERBB2 P780_Y781insGSP [plasma membrane]
(R-HSA-9646667)
ERBB2 R896H [plasma membrane]
(R-HSA-9646728)
ERBB2 G778_P780insGSP [plasma membrane]
(R-HSA-9665625)
ERBB2 G776S [plasma membrane]
(R-HSA-9664463)
ERBB2 L869R [plasma membrane]
(R-HSA-9646827)
ERBB2 L869Q [plasma membrane]
(R-HSA-9646828)
ERBB2 G776C [plasma membrane]
(R-HSA-9664457)
ERBB2 G776L [plasma membrane]
(R-HSA-9664454)
ERBB2 G776V [plasma membrane]
(R-HSA-9664450)
p-6Y-ERBB2 V777L [plasma membrane]
(R-HSA-9647214)
p-6Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9647215)
ERBB2 L755_T759del [plasma membrane]
(R-HSA-9663599)
p-6Y-ERBB2 R896C [plasma membrane]
(R-HSA-9647208)
p-6Y-ERBB2 V842I [plasma membrane]
(R-HSA-9647209)
p-6Y-ERBB2 I767M [plasma membrane]
(R-HSA-9647211)
p-6Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654692)
p-6Y-ERBB2 D769H [plasma membrane]
(R-HSA-9647200)
p-6Y-ERBB2 T798I [plasma membrane]
(R-HSA-9647202)
p-6Y-ERBB2 L755P [plasma membrane]
(R-HSA-9647196)
p-6Y-ERBB2 P780_Y781insGSP [plasma membrane]
(R-HSA-9647198)
p-6Y-ERBB2 L755S [plasma membrane]
(R-HSA-9647216)
p-6Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665650)
p-6Y-ERBB2 T798M [plasma membrane]
(R-HSA-9647218)
p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665644)
p-6Y-ERBB2 D769Y [plasma membrane]
(R-HSA-9647199)
p-6Y-ERBB2 V777E [plasma membrane]
(R-HSA-9647210)
p-6Y-ERBB2 T733I [plasma membrane]
(R-HSA-9647195)
p-6Y-ERBB2 L755M [plasma membrane]
(R-HSA-9647204)
p-6Y-ERBB2 V777M [plasma membrane]
(R-HSA-9647205)
p-6Y-ERBB2 V842E [plasma membrane]
(R-HSA-9647206)
p-6Y-ERBB2 D769N [plasma membrane]
(R-HSA-9647207)
p-6Y-ERBB2 R896H [plasma membrane]
(R-HSA-9647217)
p-6Y-ERBB2 L755W [plasma membrane]
(R-HSA-9647201)
p-6Y-ERBB2 G778_P780insGSP [plasma membrane]
(R-HSA-9665634)
p-6Y-ERBB2 H878R [plasma membrane]
(R-HSA-9647203)
p-6Y-ERBB2 E693K [plasma membrane]
(R-HSA-9665871)
p-6Y-ERBB2 R677L [plasma membrane]
(R-HSA-9665864)
p-6Y-ERBB2 Q709L [plasma membrane]
(R-HSA-9665865)
p-6Y-ERBB2 G660D [plasma membrane]
(R-HSA-9665866)
p-6Y-ERBB2 G660R [plasma membrane]
(R-HSA-9665878)
p-6Y-ERBB2 V659K [plasma membrane]
(R-HSA-9665863)
p-6Y-ERBB2 V659E [plasma membrane]
(R-HSA-9665874)
ERBB2 R678Q [plasma membrane]
(R-HSA-9665756)
ERBB2 S653C [plasma membrane]
(R-HSA-9665754)
ERBB2 R677L [plasma membrane]
(R-HSA-9665759)
ERBB2 G660R [plasma membrane]
(R-HSA-9665768)
ERBB2 V659E [plasma membrane]
(R-HSA-9665752)
ERBB2 G660D [plasma membrane]
(R-HSA-9665753)
ERBB2 V659K [plasma membrane]
(R-HSA-9665769)
ERBB2 Q709L [plasma membrane]
(R-HSA-9665770)
ERBB2 E693K [plasma membrane]
(R-HSA-9665761)
p-6Y-ERBB2 R678Q [plasma membrane]
(R-HSA-9665876)
p-6Y-ERBB2 S653C [plasma membrane]
(R-HSA-9665875)
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863841)
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863836)
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864084)
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864090)
ERBB2 [plasma membrane]
(R-HSA-372889)
p-Y877-ERBB2 [plasma membrane]
(R-HSA-1810438)
p-6Y-ERBB2 [plasma membrane]
(R-HSA-1963569)
p-6Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864081)
p-Y-ERBB2 [plasma membrane]
(R-HSA-1678589)
p-Y,Y877-ERBB2 [plasma membrane]
(R-HSA-1810446)
p-7Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864079)
p-7Y-ERBB2 [plasma membrane]
(R-HSA-1248698)
0.547
2
UniProt:Q91YW3
4
Dnajc3 [azurophil granule lumen]
(R-MMU-6799146)
Dnajc3 [extracellular region]
(R-MMU-6806239)
phospho-Dnajc3 [endoplasmic reticulum lumen]
(R-MMU-8956975)
Dnajc3 [endoplasmic reticulum lumen]
(R-MMU-448201)
0.544
2
UniProt:Q77M19 Q77M19
0.527
2
UniProt:P48039 MTNR1A
1
MTNR1A [plasma membrane]
(R-HSA-419316)
0.527
2
UniProt:Q92905 COPS5
2
COPS5 [cytosol]
(R-HSA-416963)
COPS5 [nucleoplasm]
(R-HSA-5697019)
0.527
2
UniProt:P49286 MTNR1B
1
MTNR1B [plasma membrane]
(R-HSA-419349)
0.527
2
UniProt:O94905 ERLIN2
3
ERLIN2(1-185):FGFR1(c.-88-822) fusion [plasma membrane]
(R-HSA-8853148)
ERLIN2 [endoplasmic reticulum membrane]
(R-HSA-8866520)
ERLIN2(1-185):p-8Y FGFR1(c.-88-822) fusion [plasma membrane]
(R-HSA-8853122)
0.527
2
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.527
5
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
3
UniProt:P15056 BRAF
68
BRAF-MACF1fusion [cytosol]
(R-HSA-6802402)
p-S,T-BRAF [cytosol]
(R-HSA-169856)
p-BRAF-MACF1 fusion [cytosol]
(R-HSA-6802536)
BRAF [cytosol]
(R-HSA-167224)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
BRAF G469R [cytosol]
(R-HSA-9648621)
BRAF L597R [cytosol]
(R-HSA-9648617)
BRAF G469E [cytosol]
(R-HSA-9648618)
BRAF L597Q [cytosol]
(R-HSA-9648619)
BRAF G466A [cytosol]
(R-HSA-9648613)
BRAF G466V [cytosol]
(R-HSA-9648838)
BRAF N581S [cytosol]
(R-HSA-9648850)
BRAF G464V [cytosol]
(R-HSA-9648611)
p-BRAF L597V [plasma membrane]
(R-HSA-8936647)
p-BRAF L505H [plasma membrane]
(R-HSA-9648862)
p-BRAF G464E [plasma membrane]
(R-HSA-8936645)
p-BRAF F595L [plasma membrane]
(R-HSA-8936641)
p-BRAF A246P [plasma membrane]
(R-HSA-9651188)
p-BRAF E586K [plasma membrane]
(R-HSA-8936639)
p-BRAF N581D [plasma membrane]
(R-HSA-9651191)
p-BRAF V600K [plasma membrane]
(R-HSA-8936651)
p-BRAF G464V [plasma membrane]
(R-HSA-9648633)
p-BRAF T244P [plasma membrane]
(R-HSA-9651194)
p-BRAF G469E [plasma membrane]
(R-HSA-9648634)
p-BRAF G466V [plasma membrane]
(R-HSA-9648859)
p-BRAF G469V [plasma membrane]
(R-HSA-9648628)
p-BRAF G466A [plasma membrane]
(R-HSA-9648629)
p-BRAF L597Q [plasma membrane]
(R-HSA-9648630)
p-BRAF L597R [plasma membrane]
(R-HSA-9648631)
p-BRAF N581S [plasma membrane]
(R-HSA-9648866)
p-BRAF G469R [plasma membrane]
(R-HSA-9648627)
BRAF 599dupT [cytosol]
(R-HSA-6802281)
BRAF G534R [cytosol]
(R-HSA-9651134)
BRAF S467A [cytosol]
(R-HSA-9651161)
BRAF K601N [cytosol]
(R-HSA-9648857)
BRAF G469A [cytosol]
(R-HSA-6802381)
BRAF L485F [cytosol]
(R-HSA-9651147)
BRAF Q257R [cytosol]
(R-HSA-9651157)
BRAF K499E [cytosol]
(R-HSA-9651142)
BRAF V600E [cytosol]
(R-HSA-6802498)
BRAF K601E [cytosol]
(R-HSA-9648833)
BRAF V600E V169_M438del [cytosol]
(R-HSA-6802489)
BRAF V600E V47_D380del [cytosol]
(R-HSA-6802491)
BRAF V600E V47_M438del [cytosol]
(R-HSA-6802495)
V600E BRAF V169_D380del [cytosol]
(R-HSA-6802486)
p-S445,S729-BRAF [plasma membrane]
(R-HSA-8933622)
p-S365,S445,S729 BRAF [cytosol]
(R-HSA-5672667)
hyperphosphorylated BRAF [plasma membrane]
(R-HSA-5675199)
p-S445,T599,S602,S729 BRAF [plasma membrane]
(R-HSA-5672679)
p-S445,S729-BRAF [cytosol]
(R-HSA-5672673)
p-S445,T599,S602,S729 BRAF [cytosol]
(R-HSA-5672676)
0.527
3
UniProt:Q6T424 Q6T424
0.525
3
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
0.524
2
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.508
3
UniProt:P08670 VIM
11
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.508
3
UniProt:P36780 VE2
0.488
2
UniProt:Q5NES6 Q5NES6
0.488
2
UniProt:Q8N0X7 SPART
0.462
2
UniProt:Q00005 2ABB
0.462
2
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